Molecule News and Research

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Multimodal Imaging Reveals Heterogeneity in Amyloid Plaques

Alzheimer's disease (AD), which affects millions of people globally, is still one of the most difficult and common neurodegenerative conditions.

19 Jun 2024

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

A synthetic platform that uses dimerization modules consisting of chemical proteins to precisely control the polymerization of actin and demonstrate symmetry breaking.

19 Jun 2024

Breakthrough Imaging Reveals the Dynamics of the Brain's Fast-Acting Kainate Receptor

New groundbreaking images of one of the brain's fastest-acting proteins are providing critical clues that may lead to the development of targeted therapies to treat epilepsy and other brain disorders.

18 Jun 2024

St. Jude Researchers Discover NLRC5's Role in Inflammatory Cell Death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

17 Jun 2024

MIT Researchers Develop Amber-Like Polymer for Room-Temperature DNA Storage

In the movie "Jurassic Park," scientists extracted DNA that had been preserved in amber for millions of years, and used it to create a population of long-extinct dinosaurs.

14 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

11 Jun 2024

CSHL Researchers Reveal New Protein Networks in RNA Splicing Regulation

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

11 Jun 2024

CARA Benchmark Set to Revolutionize Data-Driven Drug Discovery Methods

A compound activity prediction benchmark they curated for real-world, practical applications called Compound Activity benchmark for Real-world Applications (CARA).

11 Jun 2024

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.

10 Jun 2024

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

UC San Diego Researchers Find Cause of Cellular 'Short-Circuit'

A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.

5 Jun 2024

Researchers Advance Single-Molecule DNA Sequencing Techniques

In recent years, technologies that allow scientists to investigate a person's DNA at single-molecule resolution have greatly increased the knowledge of the human genome, microbiome, and the genetic basis of disease.

5 Jun 2024

CRISPR/Cas Biosensors Address Sensitivity and Specificity Challenges in Detection

The mechanisms of CRISPR-Cas-based biosensors.

5 Jun 2024

New Microscopy Reveals Secrets of SARS-CoV-2 Replication

Recent research published in Nature Communications by a Stanford University team may provide more accuracy in drug development by examining at the nanoscale how the SARS-CoV-2 virus replicates in cells.

4 Jun 2024

Engineered DNA PROTAC Shows Promise for p53-R175H Mutant Cancers

A synthetic bicomponent compound specifically targets and eliminates a mutant protein associated with multiple forms of cancer.

30 May 2024

Understanding the Chemistry of Chocolate and Genotoxic Compounds

What makes chocolate taste and smell so delicious? Chemistry, of course! A variety of molecules work together to create that unmistakable aroma, but those same molecules might carry some unwanted health effects if there are too many around.

30 May 2024

Revolutionizing Cell Subpopulation Studies: The ConVERGD Approach

As gene sequencing technologies become more powerful, our understanding of cellular diversity has grown in parallel.

29 May 2024

CRISPR Screening Reveals Peptide in Human RNA Regulating Inflammation

UC Santa Cruz researchers have discovered a peptide in human RNA that regulates inflammation and may provide a new path for treating diseases such as arthritis and lupus.

27 May 2024