Mutation News and Research

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Scientists Uncover a Crucial Evolutionary Threshold in Fungi

Scientists have identified a “tipping point” in fungal evolution that dramatically impacts their growth and form.

26 Mar 2024

Researchers Identify RNA-Regulator Brat as Key Player in Restraining Tissue Regeneration

Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail.

20 Mar 2024

Novel Imaging Technique Unveils Structural Details of Drug-Resistant Cancer Protein

Researchers have shown for the first time that a crucial interface in a protein that drives cancer growth could act as a target for more effective treatments.

20 Mar 2024

New Biomarker Offers Early Detection of ALS and FTD

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

19 Mar 2024

SIRPβ1 Gene Mutation Alters Alzheimer's Disease Progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

18 Mar 2024

Research Reveals the Impact of Activated Protein C on Alzheimer's Disease Pathology

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 4, entitled, "Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer's disease by activated protein C."

14 Mar 2024

New CRISPR Method Allows Comprehensive Screening of Cancer Mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways -; some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

13 Mar 2024

Evolutionary Mystery Identified in Genome of Plants

Cold Spring Harbor Laboratory (CSHL) has enabled the significant advancement of plant genomics through its involvement in sequencing the first plant genome. Now, the same research laboratory hopes to address why introducing the same mutation in different crops does not always result in the desired traits.

5 Mar 2024

Genetic Mechanisms of Alzheimer's Revealed in Colombian Kindred

UC Santa Barbara researchers and collaborators in Colombia, Brazil and Germany are progressing toward an understanding of mechanisms that underlie Alzheimer's disease, in particular an early-onset, genetic form that has afflicted generations of an extended family in Colombia.

28 Feb 2024

How Agriculture Shaped Malaria Resistance in Ancient Eastern Arabia

According to a recent study, people in ancient Eastern Arabia seem to have been resistant to malaria once agriculture arrived in the area about 5,000 years ago.

28 Feb 2024

Significant Increase in Antibiotic Resistance Genes Found in Humans and Livestock

Biomedical engineers at Duke University have discovered a significant connection between the dissemination of antibiotic resistance genes and the development of resistance to new drugs in specific pathogens

23 Feb 2024

Mutation in E. coli's Cellulose Machinery Unveiled as Cause of Severe Infections

Queensland researchers have discovered that a mutation allows some E. coli bacteria to cause severe disease in people while other bacteria are harmless, a finding that could help to combat antibiotic resistance.

22 Feb 2024

Retrotransposon-Based PRINT Technique Holds Potential for Precise Gene Insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

22 Feb 2024

Researchers Identify Genes Linked to Genomic Instability and DNA Damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

16 Feb 2024

APOE4's Influence on Lipid Droplets in Brain Cells

The largest genetic risk factor for late-onset Alzheimer's disease is apolipoprotein E (APOE), and researchers Sarah Cohen, PhD, and Ian Windham, a former PhD student from the Cohen group, have made a novel discovery about this protein.

12 Feb 2024

GWAS Identifies Key Genetic Factors for Lassa Fever Susceptibility and Severity

While combing through the human genome in 2007, computational geneticist Pardis Sabeti made a discovery that would transform her research career.

9 Feb 2024

New Research Sheds Light on Divergent Roles of Paralogous RNA Helicases

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

9 Feb 2024

Accelerating Genetic Research - The Story Behind One-pot DTECT

Dr Pierre Billon, PhD, grew increasingly frustrated with the lengthy turnaround times and high costs associated with obtaining genetic analysis from specialized private laboratories

8 Feb 2024

RNA-Seq Unveils Molecular Subtypes for Tailored Pediatric B-ALL Treatment

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases.

31 Jan 2024

Promoter Mutations and Their Association with Autism Risk

The RIKEN Center for Brain Science (CBS) employed genome mutation analysis to investigate the genetics of autism spectrum disorder (ASD) in people and their families. They found that the way a certain type of genetic mutation contributes to the illness differs from that of ordinary mutations.

29 Jan 2024