Phosphorylation News and Research

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Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

13 Oct 2020

Researchers reveal mechanism behind osimertinib resistance in some lung-cancer patients

Researchers at Kanazawa University report in Nature Communications the mechanism making some lung-cancer patients resistant to the drug osimertinib.

7 Oct 2020

Researchers unravel the molecular basis underlying colorectal cancer

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

15 Sep 2020

Scientists visualize the exact timepoint when tumor initiating cells became immortal

Worldwide, cancer is the second leading cause of death - in 2018 alone, it claimed approximately 9.6 million lives, or one in six deaths.

14 Sep 2020

Study shows how PIM kinases enhance the motility of cancer cells

PIM kinases are essentially enzymes that support the metastatic growth and proliferation of tumor cells.

20 Aug 2020

New mechanism that enables spruce trees to adapt to winter discovered

Photosynthesis in conifer forests is one of the most important carbon sinks on a global scale. Unlike broadleaf trees, conifers are evergreen and retain their photosynthesis structure throughout the year.

19 Aug 2020

Study shows how FAK protein is activated on lipid membranes

A team of researchers has recently described the mechanistic details regarding the activation of the Focal Adhesion Kinase (FAK) on lipid membranes.

12 Aug 2020

Discovery Shows Promise For Treating Huntington's Disease

Huntington disease is a progressive debilitating brain disorder that causes uncontrolled movements, psychological problems, and loss of cognition.

6 Aug 2020

Researchers identify phosphoprotein biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

29 Jul 2020

Study validates new pharmacological target for Alzheimer’s disease

A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer's disease.

28 Jul 2020

Scientists report detailed proteomic analysis of human lung adenocarcinoma

A team of Chinese scientists from the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica under the Chinese Academy of Sciences, the State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Shanghai Jiao Tong University, recently reported a comprehensive proteomic analysis based on 103 Chinese patients with lung adenocarcinoma (LUAD), a leading cause of death among all types of cancer worldwide.

10 Jul 2020