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Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Novel Matrix Supports Co-Culture of Endometrial Cells

Researchers have developed a synthetic extracellular matrix (ECM) that can facilitate the development of a miniature endometrium in a dish for at least two weeks.

14 Aug 2023

New Mechanism Regulating Tumor Growth in the Skeleton Identified

Tumor cells are known to be fickle sleeper agents, often lying dormant in distant tissues for years before reactivating and forming metastasis. Numerous factors have been studied to understand why the activation occurs, from cells and molecules to other components in the so-called tissue microenvironment.

11 Aug 2023

Do Host Social Interactions Influence Gut Bacteria Evolution?

A recent study demonstrates how host social interactions can have a significant influence on the development of gut bacteria in the gut microbiome. The study, carried out by a group of researchers from Instituto Gulbenkian de Ciência, sought to investigate the impact of host-to-host bacterial transmission on Escherichia coli (E. coli) evolution in mammalian guts.

3 Aug 2023

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

28 Jul 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Towards Artificial Photosynthesis with Engineering of Protein Crystals in Bacteria

In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties, show researchers at Tokyo Tech.

26 Jul 2023

In-Cell Engineering Proves to be a Powerful Tool for Synthesizing Functional Protein Crystals

In-cell engineering can be a powerful tool for synthesizing functional protein crystals with promising catalytic properties, show researchers at Tokyo Tech.

26 Jul 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

Teijin Frontier Introduces New Nonwoven Microcarriers for Speedy and Large-scale Cell Culture

Teijin Frontier Co., Ltd., the Teijin Group’s fibers and products converting company, today announced that it has developed a new nonwoven microcarriers that enable speedy, large-scale, high-quality cell culture.

28 Jun 2023

Innovative Technique Enables In Vivo Imaging of Intracellular Protein Aggregates

Tau aggregates have become the main study focus for figuring out the mechanisms underlying neurodegeneration since they are a prevalent form of amyloid protein. Tau fibrils and oligomers, among other forms of tau aggregates, have been linked to a variety of neurodegenerative disorders.

21 Jun 2023

Photoacoustic Spectral Analysis Shows Promise for Noninvasive Diagnosis of Tumors

Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the "tumor microenvironment" (TME).

14 Jun 2023

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor with a role in maintaining oxidative stress response. It can be triggered by both redox-dependent and redox-independent pathways.

13 Jun 2023

Charting a High-Resolution Roadmap for Regeneration of Pancreatic β Cells

At the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences (CAS), a research group headed by Professor Zhen Shao and the collaborators plotted a high-resolution roadmap for the process of pancreatic β cell regeneration by in vivo transdifferentiation from adult acinar cells with the help of a single-cell RNA sequencing (scRNA-seq) technology.

31 May 2023

in vivo News and Research

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

Novel Matrix Supports Co-Culture of Endometrial Cells

New Mechanism Regulating Tumor Growth in the Skeleton Identified

Do Host Social Interactions Influence Gut Bacteria Evolution?

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

Towards Artificial Photosynthesis with Engineering of Protein Crystals in Bacteria

In-Cell Engineering Proves to be a Powerful Tool for Synthesizing Functional Protein Crystals

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Genetically Modified iPS Cell Applications for Fabry Disease

Teijin Frontier Introduces New Nonwoven Microcarriers for Speedy and Large-scale Cell Culture

Innovative Technique Enables In Vivo Imaging of Intracellular Protein Aggregates

Photoacoustic Spectral Analysis Shows Promise for Noninvasive Diagnosis of Tumors

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Charting a High-Resolution Roadmap for Regeneration of Pancreatic β Cells

Researchers Design Artificial Fibers that can Change Shape and Generate Force Like a Muscle

Machine Learning Reveals Sex-Specific Genes, Molecular Pathways Linked to Alzheimer's Disease Progression

Targeting Cellular Respiration for the Treatment of Glioblastoma

Study Provides a New Picture of How Bacterial Cells Repair Faulty DNA

First Humanized Mouse Model for Congenital Adrenal Hyperplasia Developed

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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