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Drug meant for bacterial infections can combat weight gain

A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances.

3 Dec 2020

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary.

3 Dec 2020

Could there be harmful chemicals in your household dust?

In this interview, AZoLifeSciences spoke to Dr. Atanu Sarkar to find out what potentially harmful chemicals could be lurking in your home.

From Memorial University 27 Nov 2020

Study explains why immunotherapy works on certain patients with head and neck cancer

Researchers have found new clues about why certain individuals with head and neck cancer are able to respond to immunotherapy, while others fail to do so.

25 Nov 2020

Novel targeted therapy blocks critical metabolic pathways in cancer cells

Scientists have designed a new targeted therapy, known as POMHEX, which inhibits vital metabolic pathways in tumor cells containing specific genetic defects.

24 Nov 2020

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers have recently discovered how the function of therapeutically relevant ion channels is regulated by drug-like small molecules.

24 Nov 2020

Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Knowing precisely where proteins are frustrated could go a long way toward making better drugs. That's one result of a new study by Rice University scientists looking for the mechanisms that stabilize or destabilize key sections of biomolecules.

24 Nov 2020

Study reveals genomic structures that allow SARS-CoV-2 virus to control the infection process

An international research alliance has visualized the RNA folding structures of the SARS-CoV-2 genome, for the first time.

23 Nov 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Researchers prepare biocompatible protocells to pump up blood vessels

An international team comprising researchers from the University of Bristol, and Hunan and Central South Universities in China, have prepared biocompatible protocells.

23 Nov 2020

Vibrational motions of spike proteins correlate with infectivity, lethality of SARS-CoV-2 virus

When someone struggles to open a lock with a key that doesn't quite seem to work, sometimes jiggling the key a bit will help. Now, new research from MIT suggests that coronaviruses, including the one that causes Covid-19, may use a similar method to trick cells into letting the viruses inside.

From Massachusetts Institute of Technology (MIT) 20 Nov 2020

Scientists elucidate the structure of ABC transporter protein

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing.

19 Nov 2020

Study shows how brain protein helps pancreatic cancer cells to survive

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

19 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

At present, cannabidiol has found considerable use not just in the world of cosmetics but also in nutrition and pharmaceutics due to its therapeutic potential.

17 Nov 2020

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Scientists have determined that drugs meant for treating hepatitis C can block SARS-CoV-2 main protease, which allows reproduction in the novel coronavirus.

17 Nov 2020

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

The discovery of a potential "Achilles heel" in Nef, the protein that is crucial to HIV virulence and its capacity to trigger AIDS, paves the way for the development of a new class of drugs against the virus.

17 Nov 2020

New research uncovers vital link in complex biochemical pathway for saponin synthesis

Many plants, including legumes, make naturally occurring chemicals called saponins. For example, the medicinal plant licorice produces the saponin glycyrrhizin, a potent natural sweetener that also has antiviral and other pharmacological activity. Soyasaponins, found in soybeans, have anticarcinogenic and antioxidant properties.

From Osaka University 17 Nov 2020

New way to predict who will respond to cancer therapies that block Wnt production

Scientists have identified possible means to prognosticate who will respond to cancer therapies that inhibit Wnt production.

16 Nov 2020

Molecule News and Research

Drug meant for bacterial infections can combat weight gain

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

Could there be harmful chemicals in your household dust?

Study explains why immunotherapy works on certain patients with head and neck cancer

Novel targeted therapy blocks critical metabolic pathways in cancer cells

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Study reveals genomic structures that allow SARS-CoV-2 virus to control the infection process

First functional analysis of cytokine IL-15L using rainbow trout

Researchers prepare biocompatible protocells to pump up blood vessels

Vibrational motions of spike proteins correlate with infectivity, lethality of SARS-CoV-2 virus

Scientists elucidate the structure of ABC transporter protein

Study shows how brain protein helps pancreatic cancer cells to survive

Tau protein in Alzheimer's disease looks different at every dementia stage

Gold nanoparticles put spotlight on small drug molecules in live cells

Study finds that cannabidiol induces the expression of heme oxygenase 1 in skin cells

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Discovery of 'Achilles heel' in protein crucial to HIV virulence paves way for new drugs

New research uncovers vital link in complex biochemical pathway for saponin synthesis

New way to predict who will respond to cancer therapies that block Wnt production

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