Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

In vivo generation of engineered CAR T cells to treat heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

7 Jan 2022

Severe lung injuries can trigger stem cells to undergo abnormal differentiation, study finds

Severe injuries to the lung from diseases such as COVID-19 trigger abnormal stem cell repair that alters the architecture of the lung. The aberrant stem cell differentiation in response to injury can prevent the restoration of normal lung function.

31 Dec 2021

Researchers discover a link between genetic variant and chronic hypersensitivity pneumonitis

Chronic hypersensitivity pneumonitis (CHP) is a long-term lung condition where the interstitial tissue surrounding the alveoli (air sacs) of the lungs becomes inflamed and develops "fibrosis", or scar tissue.

17 Nov 2021

Macrophages found in cardiac tissue protect the failing heart, says study

The Centers for Disease Control and Prevention states that heart failure impacts over six million Americans and is the major reason for death.

17 Nov 2021

Experts identify novel mechanisms involved in macrophage polarization

Macrophages are important cells of the immune system with numerous beneficial functions. However, macrophages also aggravate common diseases.

8 Nov 2021

Research opens new therapeutic perspectives for treatment of skin fibrosis

Collagen, the main component of the skin's extracellular matrix, can cause a pathological condition if it is in excess. Applying an electric field to the skin affects collagen pathways, temporarily reducing collagen production and increasing its degradation.

22 Oct 2021

Experts develop antibodies that effectively remove senescent cells

The reason why some people age worse than others and develop diseases linked to the aging mechanism is largely unknown.

22 Oct 2021

Disproving the classical theory of protein folding phenomenon

Proteins are the messengers, workers, managers, and directors of mostly all intra- and inter-cellular functions in the human body.

7 Oct 2021

Radiation therapy can reprogram heart muscle cells to a younger state, suggests study

New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure.

27 Sep 2021

Researchers show how 'bad mucin' contributes to worsening pulmonary conditions

Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways.

23 Sep 2021

Potential biomarkers help diagnose progressive stages of liver disease

Results of national research pinpointed potential biomarkers that could ultimately be employed for the diagnosis of progressive stages of liver disease.

23 Sep 2021

Premature aging of the tracheobronchial stem cells could contribute to chronic lung disease

Are prematurely aged or overworked stem cells a significant factor in chronic lung disease? Findings of a study just released in STEM CELLS Translational Medicine (SCTM) say this is likely so.

22 Sep 2021

Combining bacteriophages with antibiotics to treat antibiotic-resistant infections

Mycobacterium abscessus, a relative of the bacteria that cause tuberculosis and leprosy, is responsible for particularly severe damage to human lungs and can be resistant to many standard antibiotics, making infections extremely challenging to treat.

17 Sep 2021

Scientists develop lung organoids to imitate actual SARS-CoV-2 infection

The emergence of the COVID-19 pandemic in the United States in early 2020 left researchers struggling to identify lab models of SARS-CoV-2 infection.

From UC San Diego 2 Sep 2021

Researchers use prime editing to correct mutations causing cystic fibrosis in organoids

A team of scientists rectified mutations that result in cystic fibrosis in cultured human stem cells.

11 Aug 2021

Specific subset of fibroblast cells could provide protection from debilitating lung disease

Single-cell RNA sequencing has revealed a subset of cells that could provide protection from a rare, but severely debilitating and fatal, lung disease.

16 Jul 2021

Cells damaged by chronic lung disease favor SARS-CoV-2 entry

Researchers propose that similar to pouring water atop a wellhead prior to pumping, the airway cells of patients suffering from chronic lung diseases are “primed” for infection by the COVID-19 virus.

16 Jul 2021

Liver fibrosis might be treatable with selective immunotoxins

Chronic alcohol abuse and hepatitis can injure the liver and lead to fibrosis, the buildup of collagen and scar tissue. As a potential approach to treating liver fibrosis, University of California San Diego School of Medicine researchers and their collaborators are looking for ways to stop liver cells from producing collagen.

13 Jul 2021

A new treatment approach against SARS-CoV-2

Scientists have come up with a new method to treat SARS-CoV-2 infection by fixing the cell damage instead of fighting the virus directly.

21 Jun 2021

Diet plays a crucial role in liver disease outcome, mouse model shows

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD patients are at higher risk of developing Non-alcoholic steatohepatitis (NASH), which causes severe and chronic liver inflammation, fibrosis and liver damage.

2 Jun 2021