Kinase News and Research

RSS

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.

1 Oct 2021

Study reveals the biology and treatment behind rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

20 Aug 2021

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

6 Aug 2021

Researchers identify inhibitor that converts immune cold cancer to red hot ones

Scientists headed by the University of Michigan Rogel Cancer Center converted an immune cold cancer into one that responds to immunotherapy.

4 Aug 2021

Study unravels novel centromeric functional protein

Scientists have discovered a new centromeric functional protein and dubbed it Adaptor of polo1 (Apolo1). The findings of the study were reported in Cell Reports.

27 Jul 2021

Study identifies a signaling protein that controls the assembly of mitochondria

Scientists from the University of Freiburg have identified a signaling protein that regulates the assembly of human cellular “power plants.”

21 Jul 2021

New method to control the complex communication network of cells

A study has proposed a new method for developing novel drugs based on the suppression of tyrosine kinase enzymes.

21 Jun 2021

Presence of certain stem cells correlates with non-genetic resistance mechanisms to cancer drugs

Cancer cells can develop resistance to therapy through both genetic and non-genetic mechanisms. But it is unclear how and why one of these routes to resistance prevails.

18 Jun 2021

Novel protein could improve treatment outcomes after heart attacks

New research, headed by scientists from Washington State University, has revealed a protein that could be crucial for enhancing treatments after a heart attack.

4 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021

Researchers discover a new, effective way to treat aggressive blood cancer in children

Australian scientists have found what could prove to be a new and effective way to treat a particularly aggressive blood cancer in children.

31 May 2021

Light-controlled on/off switch can help reset the biological clock

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally.

26 May 2021

Exploring the Genetic effects of Chernobyl Radiation

In this interview, AZoLifeSciences speaks to researchers from the National Cancer Institute about their latest research that investigated the genetic effects of Chernobyl radiation.

From National Cancer Institute (NCI) 13 May 2021

Researchers devise a small-molecule cocktail to protect stem cells from stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Cutting-edge genomic tools used to investigate health effects of Chernobyl radiation exposure

In two landmark studies, researchers have used cutting-edge genomic tools to investigate the potential health effects of exposure to ionizing radiation, a known carcinogen, from the 1986 accident at the Chernobyl nuclear power plant in northern Ukraine.

From National Cancer Institute (NCI) 23 Apr 2021

Discovering a new genetic mutation in Schizophrenia

A new genetic mutation has been discovered in schizophrenia, and we spoke to Dr. Todd Lencz from the Feinstein Institutes for Medical Research to find out more.

From Northwell Health 1 Apr 2021

Study reveals mechanism by which ibuprofen prevents RAC1B alternative splicing in colorectal cells

Oncotarget published "Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein complex required for expression of tumor-related splicing variant RAC1B in colorectal cells" which reported that although the molecular mechanism behind the antitumor properties of NSAIDs has been largely attributed to inhibition of cyclooxygenases , several studies have shown that the chemopreventive properties of ibuprofen also involve multiple COX-independent effects.

23 Mar 2021

Protein kinases may offer a solution to treat HIV patients with immunodeficiency

A new study indicates that protein kinases, which initiate the process that erodes the body’s immunity, significantly contribute to the immunodeficiency in HIV patients. Drugs that block these protein kinases may offer a solution to treating HIV patients whose immunity is not restored by antiretroviral therapy.

2 Mar 2021

Enzyme in fruit fly larvae plays key role in waking up brain stem cells

Researchers studying an enzyme in fruit fly larvae have found that it plays an important role in waking up brain stem cells from their dormant 'quiescent' state, enabling them to proliferate and generate new neurons.

12 Feb 2021

Researchers program genome tool to target specific histone proteins

If finding a needle in a haystack is hard enough, then one should try finding a particular molecule on the needle.

11 Feb 2021