Genetic News and Research

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“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Combining discoveries in cancer immunology with sophisticated genetic engineering, Columbia University researchers have created a sort of "bacterial suicide squad" that targets tumors, attracting the host's own immune cells to the cancer to destroy it. The new work, published today in Science Advances, marks a major step forward in efforts to enlist non-pathogenic bacteria to combat cancer.

9 Mar 2023

Experts sequence the faba bean genome

The faba bean genome, which at 13 billion bases is more than four times the size of the human genome, has been sequenced for the first time and is published today (08 March 2023), in Nature. This is an extraordinary technical achievement and crucial to efforts to breed beans with optimum nutritional content and sustainability of production.

8 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

New research led by investigators at Massachusetts General Hospital, a founding member of Mass General Brigham, indicates that socioeconomic and genetic factors likely interact in an additive way to affect people's risks of developing obesity and type 2 diabetes.

8 Mar 2023

An alternative option to treat ADCY5-related dyskinesia in patients

The asthma medication theophylline can be used to treat the movement disorder ADCY5-related dyskinesia. A recent study conducted by Martin Luther University Halle-Wittenberg (MLU), University Medicine Halle, and the University of Leipzig Medical Center demonstrated this.

7 Mar 2023

Using data from Sanger sequencing to quantify of genetic variants in bacterial cultures

Genetic variations, such as mutations, recombinations, or transpositions occur naturally in cultured microorganisms and are often considered nonneutral mutations.

7 Mar 2023

Significance of large-scale genetic studies in men of African ancestry

Investigators at USC’s Keck School of Medicine directed the meta-analysis, which discovered nine new genetic variants that boost the risk of prostate cancer in an under researched population, including a genetic risk score connected to aggressive forms of the disease.

6 Mar 2023

Largest-ever genetic analysis provides insight into domestications and origin of traits in grapevine

In the largest ever genetic analysis of grapevine varieties, including samples from previously undocumented specimens in private collections, researchers provide new insights into how, when, and where wine and table grapevines were domesticated, which has been a longstanding question.

3 Mar 2023

New insights into the underlying mechanism that causes arrhythmogenic cardiomyopathy

Researchers from the group of Eva van Rooij in collaboration with the UMC Utrecht identified a new mutation that leads to the cardiac disease arrhythmogenic cardiomyopathy (ACM).

3 Mar 2023

Innovative method to quickly identify bacteria in fluids

Shine a laser on a drop of blood, mucus, or wastewater, and the light reflecting back can be used to positively identify bacteria in the sample.

3 Mar 2023

New insights into the distribution and regulation of meiotic DSB hotspots

A new method, DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling was developed recently.

3 Mar 2023

Uncovering the complete 3D structure of p53 protein

By inducing cell repair or self-destruction, the tumor suppressor protein p53, often known as “the guardian of the genome,” shields the body’s DNA from daily stress or long-term damage.

2 Mar 2023

An important piece of the puzzle of Europe's genetic history disclosed

Recent research discloses genomic data from a 23,000-year-old individual who inhabited what was most likely Europe’s warmest location during the last Ice Age.

2 Mar 2023

New signals of natural selection in humans identified

A team of global experts has discovered new signals of natural selection in humans.

2 Mar 2023

Researchers find methods to awaken and revive neural stem cells

Some areas of the adult brain contain quiescent, or dormant, neural stem cells that can potentially be reactivated to form new neurons. However, the transition from quiescence to proliferation is still poorly understood. A team led by scientists from the Universities of Geneva (UNIGE) and Lausanne (UNIL) has discovered the importance of cell metabolism in this process and identified how to wake up these neural stem cells and reactivate them. Biologists succeeded in increasing the number of new neurons in the brain of adult and even elderly mice. These results, promising for the treatment of neurodegenerative diseases, are to be discovered in the journal Science Advances.

2 Mar 2023

Elaborating how amino acids shaped the genetic code of ancient microbes

Researchers discovered that without specific amino acids, ancient proteins would not have identified how to evolve into anything alive on the planet today, including plants, animals, and humans, by mimicking early Earth conditions in the lab.

28 Feb 2023

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

The Lieber Institute for Brain Development has received a $1 million, two-year grant from the Chan Zuckerberg Initiative to support the work of the African Ancestry Neuroscience Research Initiative (AANRI) to promote racial equity throughout the field of neuroscience.

28 Feb 2023

Redefining low-risk WNT-pathway medulloblastoma based on newer biological information

A new research perspective was published in Oncotarget's Volume 14 on February 7, 2023, entitled, "WNT-pathway medulloblastoma: what constitutes low-risk and how low can one go?"

28 Feb 2023

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA) -;a joint institute of the CSIC and the University of Zaragoza-; have developed a new method to detect RNA viruses based on the triplex-forming probe technology.

28 Feb 2023

Genetic News and Research

“Bacterial suicide squad” recruits and activates innate and adaptive antitumor immune responses

Experts sequence the faba bean genome

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

An alternative option to treat ADCY5-related dyskinesia in patients

Using data from Sanger sequencing to quantify of genetic variants in bacterial cultures

Significance of large-scale genetic studies in men of African ancestry

Largest-ever genetic analysis provides insight into domestications and origin of traits in grapevine

New insights into the underlying mechanism that causes arrhythmogenic cardiomyopathy

Innovative method to quickly identify bacteria in fluids

New insights into the distribution and regulation of meiotic DSB hotspots

Uncovering the complete 3D structure of p53 protein

An important piece of the puzzle of Europe's genetic history disclosed

New signals of natural selection in humans identified

Researchers find methods to awaken and revive neural stem cells

Elaborating how amino acids shaped the genetic code of ancient microbes

Lieber Institute awarded $1 million grant to foster racial diversity across neuroscience

Redefining low-risk WNT-pathway medulloblastoma based on newer biological information

Effective and faster methodology detects RNA viruses based on the triplex-forming probe technology

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