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New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.

30 Apr 2021

Geisinger receives $3.6 million from NCI to study the role of genetic variation in cancer

The National Cancer Institute, part of the National Institutes of Health, has awarded a 5-year, $3.6 million contract to Geisinger to study the role of genetic variation in cancer.

30 Apr 2021

Researchers discover new approach to reform plant breeding and genetics

The research was conducted at the Department of Food Science at the University of Copenhagen (UCPH FOOD) with professor emeritus Lars Munck as coordinator and builds on earlier work since 1963 at Svaloef Plant Breeding Institute and the Carlsberg Laboratory.

28 Apr 2021

New computer algorithm helps identify tumors with 'mismatch repair deficiencies'

A new way to identify tumors that could be sensitive to particular immunotherapies has been developed using data from thousands of NHS cancer patient samples sequenced through the 100,000 Genomes Project.

27 Apr 2021

SDIR1 enzyme plays a major role in the expression of defense gene in plants

A new study offers evidence that microbes are trying to hijack the plant immune system to induce disease while also offering insights into a new mechanism.

26 Apr 2021

Study shows how different organisms can prevent deadly DNA damage during evolution

Researchers from the University of Bergen discovered how species ranging from crops to corals can prevent harmful DNA damage during evolution.

26 Apr 2021

Cell membranes can boost the production of protein-based vaccines

Synthetic biologists have cracked open a cellular membrane, identifying a new method to boost the production yields of protein-based vaccines by five times.

26 Apr 2021

National DNA Day 2021: The Importance of DNA in Research

To celebrate National DNA Day, AZoLifeSciences speaks to Belen Hurle from the National Human Genome Research Institute about the importance of DNA in research.

From National Human Genome Research Institute (NHGRI) 26 Apr 2021

Cutting-edge genomic tools used to investigate health effects of Chernobyl radiation exposure

In two landmark studies, researchers have used cutting-edge genomic tools to investigate the potential health effects of exposure to ionizing radiation, a known carcinogen, from the 1986 accident at the Chernobyl nuclear power plant in northern Ukraine.

From National Cancer Institute (NCI) 23 Apr 2021

National DNA Day 2021: An Interview with Professor George Church

In celebration of National DNA Day, AZoLifeSciences interviews renowned DNA expert Professor George Church about his life-long career in DNA research.

From Harvard Medical School 23 Apr 2021

Study identifies mechanism that enables SARS viruses to efficiently replicate in infected cells

Researchers have now identified how SARS viruses improve the production of viral proteins in infected cells such that new copies of the virus can be produced.

23 Apr 2021

Study finds raised levels of specific immune cells in asymptomatic people with COVID-19

The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus.

21 Apr 2021

Researchers uncover a key genetic culprit in the development of acute lymphoblastic leukemia

Using a widely known field of mathematics designed mainly to study how digital and other forms of information are measured, stored and shared, scientists at Johns Hopkins Medicine and Johns Hopkins Kimmel Cancer Center say they have uncovered a likely key genetic culprit in the development of acute lymphoblastic leukemia (ALL).

21 Apr 2021

Supercomputer simulations reveal the behavior of dominant G form SARS-CoV-2 strain

Large-scale supercomputer simulations at the atomic level show that the dominant G form variant of the COVID-19-causing virus is more infectious partly because of its greater ability to readily bind to its target host receptor in the body, compared to other variants.

19 Apr 2021

New CRISPR technology allows scientists to switch off any gene in human cells

Scientists have figured out how to modify CRISPR's basic architecture to extend its reach beyond the genome and into what's known as the epigenome -- proteins and small molecules that latch onto DNA and control when and where genes are switched on or off.

19 Apr 2021

“Expansion Hunter” approach can detect DNA errors

Researchers from Radboud University Medical Center have successfully detected hidden genetic defects by using an existing technique on existing datasets. The team demonstrated that the “Expansion Hunter” approach can detect DNA errors that cause repeat expansion diseases, like ataxia—a movement disorder.

16 Apr 2021

Researchers use information embedded in microbial genes as a biosensor of ocean health, productivity

Scientists from the University of California, Irvine, analyzed gains and losses in the genes of phytoplankton samples gathered from all major ocean regions to develop the most refined and highest-resolution map that shows where these photosynthetic organisms either survive or are forced to adapt to restricted amounts of main nutrients, nitrogen, iron, and phosphorus.

16 Apr 2021

Study reveals RNA regulatory mechanisms within transcription-translation couplings

To gain a better understanding of how bacterial RNA gives rise to proteins scientists are now focusing on the special way this process takes place in bacteria.

15 Apr 2021

Ebola virus protein changes shape by using human RNA

The human genome contains the instructions to make tens of thousands of proteins. Each protein folds into a precise shape--and biologists are taught that defined shape dictates the protein's destined function. Tens of thousands of singular shapes drive the tens of thousands of needed functions.

15 Apr 2021

Scientists characterize the genetic diversity of populations in the South Pacific

Describing the genetic diversity of human populations is essential to improve our understanding of human diseases and their geographical distribution.

From Institut Pasteur 15 Apr 2021

Genome News and Research

New integrative genetic screening technology offers insights into role of DNA accessibility in cancer

Geisinger receives $3.6 million from NCI to study the role of genetic variation in cancer

Researchers discover new approach to reform plant breeding and genetics

New computer algorithm helps identify tumors with 'mismatch repair deficiencies'

SDIR1 enzyme plays a major role in the expression of defense gene in plants

Study shows how different organisms can prevent deadly DNA damage during evolution

Cell membranes can boost the production of protein-based vaccines

National DNA Day 2021: The Importance of DNA in Research

Cutting-edge genomic tools used to investigate health effects of Chernobyl radiation exposure

National DNA Day 2021: An Interview with Professor George Church

Study identifies mechanism that enables SARS viruses to efficiently replicate in infected cells

Study finds raised levels of specific immune cells in asymptomatic people with COVID-19

Researchers uncover a key genetic culprit in the development of acute lymphoblastic leukemia

Supercomputer simulations reveal the behavior of dominant G form SARS-CoV-2 strain

New CRISPR technology allows scientists to switch off any gene in human cells

“Expansion Hunter” approach can detect DNA errors

Researchers use information embedded in microbial genes as a biosensor of ocean health, productivity

Study reveals RNA regulatory mechanisms within transcription-translation couplings

Ebola virus protein changes shape by using human RNA

Scientists characterize the genetic diversity of populations in the South Pacific

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