Malignant News and Research

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Cancer cells can exchange and recombine their genetic material, shows study

Evolution within groups of tumor cells follows the principles of natural selection, as evolution in pathogenic microbes.

22 Jan 2021

Investigational antisense medicine lowers disease burden, reduces myeloma cell abundance in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

From UC San Diego 21 Jan 2021

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process.

20 Jan 2021

Microbe found in the colon may promote breast cancers

A microbe found in the colon and commonly associated with the development of colitis and colon cancer also may play a role in the development of some breast cancers, according to new research from investigators with the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

7 Jan 2021

Scientists resolve long-standing debate over key mechanism involved in gene silencing

Scientists from Massachusetts General Hospital (MGH) have resolved a long-standing debate over how crucial gene-silencing protein detects its targets.

5 Jan 2021

Combination method can boost immunotherapy for breast cancer

According to a new study performed by scientists from the University of North Carolina, stimulating an immune signaling pathway, which is best known for combating bacterial and viral infections, can increase the potential of genetically engineered T cells to remove breast cancer in mice.

4 Jan 2021

HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

29 Dec 2020

Study uncovers how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

From UC San Diego 24 Dec 2020

New analysis technique could pave way for major breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukaemia.

14 Dec 2020

Researchers discover protein crucial for growing life-saving blood stem cells

A group of scientists from the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City has discovered a protein that is crucial for expanding the usually scarce, life-saving blood stem cells.

11 Dec 2020

Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Using 3D mapping techniques to unravel mystery of blood stem cells

Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells.

26 Nov 2020

Study may lead to new strategies that minimize inflammatory reactions after cell transplants

The term leukaemia is used to describe a group of malignant diseases of the haematopoietic system, in which precursors of the white blood cells (leucocytes) proliferate uncontrollably.

20 Nov 2020

Study suggests that melatonin may be a viable treatment option for COVID-19

New findings indicate that melatonin could be a potential treatment option for COVID-19.

10 Nov 2020

Scientists discover link between two signaling pathways crucial to growth of colon cancer

In breakthrough colon cancer research, scientists at ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is published today in the journal PLOS ONE.

29 Oct 2020

Malignant News and Research

Cancer cells can exchange and recombine their genetic material, shows study

Investigational antisense medicine lowers disease burden, reduces myeloma cell abundance in mice

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Microbe found in the colon may promote breast cancers

Scientists resolve long-standing debate over key mechanism involved in gene silencing

Combination method can boost immunotherapy for breast cancer

HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

Study uncovers how shattered chromosomes make cancer cells more aggressive

New analysis technique could pave way for major breakthroughs in immunotherapy

Researchers discover protein crucial for growing life-saving blood stem cells

Study reveals new target to make breast cancer more sensitive to immunotherapy

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Using 3D mapping techniques to unravel mystery of blood stem cells

Study may lead to new strategies that minimize inflammatory reactions after cell transplants

Study suggests that melatonin may be a viable treatment option for COVID-19

Scientists discover link between two signaling pathways crucial to growth of colon cancer

Researchers discover new ways to block the colonization and spread of tumor cells

VAV1 gene mutations may promote growth of T-cell tumors in laboratory mice

Developing a 'Trojan Horse' nanotherapy to fight breast cancer

Study shows thymoquinone compound selectively kills prostate cancer cells

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