Neurodegenerative Diseases News and Research

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Multiple changes in brain cells during embryonic development may contribute to schizophrenia

Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.

17 Dec 2021

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

A common gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia, according to a new study publishing December 16th in the open-access journal PLOS Biology, by Mark Cookson of the National Institute on Aging and colleagues.

17 Dec 2021

New method to generate embryo-like cell complexes from the stem cells of mice

Researchers at the University of Bonn have developed a method to generate embryo-like cell complexes from the stem cells of mice. The method provides new insights into embryonic development. In the medium term, it might also be suitable for developing tests for substances that could be harmful to fertility. The study is published in the prestigious journal Nature Communications.

17 Dec 2021

Detachable head-mounted photoacoustic microscope images brain activity in mice

Scientists recently generated the first detachable head-mounted photoacoustic microscope for imaging brain activity in freely roaming mice.

13 Dec 2021

First molecular structure of TDP-43 could pave the way for new ALS therapies

Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases.

9 Dec 2021

Cancer drug effective against Alzheimer’s disease, says research

According to recent research carried out by researchers from the Weill Cornell Medicine, a gene mutation associated with Alzheimer’s disease changes a signaling pathway in specific immune cells of individuals with the disease.

7 Dec 2021

Researchers find that the VCP/p97 protein unfolds, separates other protein structures

Thanks to an old needlework trick that a protein in the human body is aware of, rather than threading yarn into the eye from the end, it could be simpler to pass a loop through it.

2 Dec 2021

Tough protein connects directly with neurons to cause damaging inflammatory reaction in the brain

Neuroinflammatory diseases, including Alzheimer's disease and traumatic brain injury, have been linked to deposits of a tough protein known as fibrin, derived from the blood clotting factor fibrinogen.

9 Nov 2021

Multiple sclerosis drug improves memory in mouse model of Alzheimer's disease

Losing memory is a hallmark of Alzheimer's, a symptom of the disease that depletes a patient's quality of life. Improving memory and slowing cognitive changes caused by the disease is an ongoing challenge for researchers seeking to develop novel therapies.

8 Nov 2021

Immune cell patterns can help predict kidney cancer patients' response to immunotherapy

Researchers at the Francis Crick Institute, The Royal Marsden NHS Foundation Trust and UCL have found immune cell patterns within tumors that can help predict if patients with kidney cancer will respond to immunotherapy.

29 Oct 2021

'Mini brains' allow researchers to study a fatal, untreatable neurological disorder

Cambridge researchers have developed 'mini brains' that allow them to study a fatal and untreatable neurological disorder causing paralysis and dementia – and for the first time have been able to grow these for almost a year.

22 Oct 2021

Viral diseases likely to contribute to neurodegeneration, says study

Scientists from DZNE revealed that certain viral diseases can contribute to neurodegeneration.

21 Oct 2021

Research illustrates the complex mechanism of bacterial innate immunity

Recent research anticipates utilizing newly characterized defense systems in bacteria to match changes to the human genome.

From Durham University 21 Oct 2021

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

At the beginning of neurodegenerative disease, the immune cells of the brain – the "microglia" – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed.

18 Oct 2021

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

12 Oct 2021

Ketone supplement may be a new therapeutic strategy for enhancing brain health in adults with obesity

New research published in The Journal of Physiology has shown that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.

5 Oct 2021

Exploring cell and gene based therapies for Parkinson’s disease

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored. In this special supplement to the Journal of Parkinson's Disease on "Repairing the Parkinsonian Brain," experts highlight some of the current strategies being pursued to restore lost function and replace what is lost in the PD brain, with special emphasis on the challenges associated with translating advanced therapeutic approaches into pioneering clinical trials.

24 Sep 2021

Microglial cells join together to break down toxic proteins more quickly

To break down toxic proteins more quickly, immune cells in the brain can join together to form networks when needed. This is shown by a joint study of the University of Bonn, the German Center for Neurodegenerative Diseases, and the Institut François Jacob in France.

23 Sep 2021

Study identifies vital factor involved in the evolution of the human brain

Humans have a huge and intricately folded neocortex, the reason for various intellectual abilities, setting apart humans from all other species.

17 Sep 2021

Bacteria-derived curli amyloid fibril promotes neurodegeneration in the host

Increasing evidence points to the fact that gut microbiota performs a vital role in regulating the advancement of neurodegenerative diseases like Alzheimer’s.

9 Sep 2021

Neurodegenerative Diseases News and Research

Multiple changes in brain cells during embryonic development may contribute to schizophrenia

Gene mutation for Parkinson's disease drives mislocalization of iron in activated microglia

New method to generate embryo-like cell complexes from the stem cells of mice

Detachable head-mounted photoacoustic microscope images brain activity in mice

First molecular structure of TDP-43 could pave the way for new ALS therapies

Cancer drug effective against Alzheimer’s disease, says research

Researchers find that the VCP/p97 protein unfolds, separates other protein structures

Tough protein connects directly with neurons to cause damaging inflammatory reaction in the brain

Multiple sclerosis drug improves memory in mouse model of Alzheimer's disease

Immune cell patterns can help predict kidney cancer patients' response to immunotherapy

'Mini brains' allow researchers to study a fatal, untreatable neurological disorder

Viral diseases likely to contribute to neurodegeneration, says study

Research illustrates the complex mechanism of bacterial innate immunity

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

Ketone supplement may be a new therapeutic strategy for enhancing brain health in adults with obesity

Exploring cell and gene based therapies for Parkinson’s disease

Microglial cells join together to break down toxic proteins more quickly

Study identifies vital factor involved in the evolution of the human brain

Bacteria-derived curli amyloid fibril promotes neurodegeneration in the host

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