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A Novel Regulator of RNA Processing in Alzheimer's Disease

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies the process of protein synthesis and impacts RNA processing in Alzheimer's patients' brains.

21 Oct 2024

Novel Technique to Study Ubiquitination

Once human proteins are synthesized, they go through some chemical changes. These adjustments control their stability, functionality, and structure.

13 Aug 2024

Protein Imbalance Linked to Rare Developmental Disorder

According to a recent study from the University of Lausanne, serious intellectual impairments can result from both an excess or a shortage of a single protein.

31 May 2024

Engineered DNA PROTAC Shows Promise for p53-R175H Mutant Cancers

A synthetic bicomponent compound specifically targets and eliminates a mutant protein associated with multiple forms of cancer.

30 May 2024

PhoreMost Introduces GlueSEEKER Platform for Discovery of Molecular Glue Degraders

PhoreMost Ltd., a leading UK biopharmaceutical company unlocking the next generation of drug targets, today announced the introduction of GlueSEEKER™. The new phenotypic screening platform expands the Company’s capabilities in this emerging therapeutic modality to support the systematic discovery and development of novel molecular glue degraders (MGDs) for targeted protein degradation (TPD).

From PhoreMost 22 May 2024

Decoding the Secrets of Ribosome Recycling at the Endoplasmic Reticulum

Researchers from Stanford University and LMU have uncovered how cells renew their endoplasmic reticulum’s protein factories.

26 Feb 2024

Nanopore Sequencing Sheds Light on Plant Growth Trigger

Researchers from the Southern University of Science and Technology, under the direction of Prof. Xiaofeng Cao from the Chinese Academy of Sciences’ Institute of Genetics and Developmental Biology, recently reported a new understanding of how light affects plant growth in a study that was published in the PNAS.

5 Feb 2024

Scientists Discover New Class of Molecular Glue Degraders for Cancer Therapy

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis.

17 Nov 2023

Scientists Develop Molecular Radar to Detect Active Cullin-RING Ligases

Our cells have a fleet of 300 molecular machines, called cullin-RING ligases, or "CRLs" for short, that each is capable of triggering destruction of specific proteins for the well-being of our cells.

27 Sep 2023

Previously Unknown Protein Reveals RNA Repair Mechanism in Humans

Ribonucleic acids (RNAs) are single-stranded molecules that are found in all living organisms’ cells. As “transcripts” of human genes, mRNAs, for instance, play a role in the translation of genetic information by bearing the instructions for the production of a protein in their own sequence.

26 Apr 2023

TurboID-based proximity labeling in meiotic cells of Arabidopsis thaliana

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings.

14 Mar 2023

Study identifies genetic variants linked to mathematical abilities in children

A new study published in Genes, Brain and Behavior has identified several genetic variants that may be linked with mathematical abilities in children.

23 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

Revealing the mechanism that ensures genome stability in normal cells

To create new cells, the old cells must divide. This is a constant, frequent, and pervasive process that begins with conception and culminates with death.

30 Nov 2022

BIDMC researchers develop a transformative approach to make more of beige adipose tissues

Once considered an inert tissue, fat – or adipose tissue – is now known to play an active role in the body's critical functions by secreting hormones that regulate hunger and body temperature.

18 Aug 2022

Proximity-dependent biotinylation helps analyze protein interaction

Protein degraders, which cause target proteins to break down, are thought to be the “next-generation drugs” because they may eliminate disease-causing proteins from cells.

9 Mar 2022

First molecular images of enzyme may help solve the mystery cause of hereditary neurodegenerative diseases

WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 13 Jan 2022

Robust electron microscope provides mechanistic insight into protein degradation

Proteins are the building blocks of all living things and numerous studies are carried out to determine how these proteins are made and their function.

19 Nov 2021

New gene critical for daily behavioral rhythms discovered

Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type.

16 Nov 2021

Yeast study reveals a protein involved in gross chromosomal rearrangements

Gross chromosomal rearrangements--where portions of the genome become moved, deleted, or inverted--can lead to cell death and diseases such as cancer in complex multicellular organisms.

23 Jul 2021