Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

New Method for Identifying Kinase Inhibitors for Cancer Therapy

The most difficult subtype of breast cancer to treat is triple-negative breast cancer (TNBC). Over 20,000 cases of TNBC are reported each year in the United States alone.

10 Oct 2024

Lipids Found to Play Key Role in Cancer Immune Evasion

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.

18 Sep 2024

AMLo Biosciences Receives UKCA Mark for Groundbreaking Melanoma Biomarker Test

AMLo Biosciences Ltd (Newcastle upon Tyne, UK) announces the successful receipt of the UKCA mark for AMBLor. AMBLor is a groundbreaking histopathological biomarker test for the personal identification of early-stage melanomas at low risk of progression, post staging diagnosis.

6 Sep 2024

Nutrient Deprivation Strategy Kills Breast Cancer Cells by Blocking Adaptive Pathways

Cancer cells have voracious appetites. And there are certain nutrients they can't live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells' diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their metabolism and switching to backup food supplies.

29 Aug 2024

New Tool Revolutionizes Cell Migration Research with Simplified Data Analysis

Studying cell migration is vital because it plays a crucial role in many biological processes, including immune response, wound healing, and cancer metastasis.

19 Aug 2024

Lipid Nanoparticle-Encapsulated miR-193a-3p Mimic INT-1B3 Boosts Anti-Tumor Immunity

A new research paper was published in Oncotarget's Volume 15 on July 12, 2024, entitled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death."

6 Aug 2024

High-resolution 3D maps of diseased tissues at the subcellular level

Molecular maps from patient tissue samples can be created with subcellular precision using an open-source platform created by researchers in the lab of Nikolaus Rajewsky at the Max Delbrück Center. This allows for in-depth analysis and may improve routine clinical pathology. The research was published in the journal Cell.

25 Jun 2024

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Using transcriptomics and radiomics data clustering and its association with molecular characteristics, clinical pathologies, and prognosis to define intrinsic subtypes of ccRCC.

24 Jun 2024

Mesenchymal stem cell-derived exosomes carrying vincristine sulfate are effective in killing cancer stem cells

Whether loading vincristine sulfate into mesenchymal stem cell-derived exosomes could improve the targeted delivery of the drug specifically to cancer stem cells.

21 May 2024

Study Reveals Dual Contractility Modes in Cancer Cell Invasion

Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself.

8 May 2024

Cataloging Bacteria in Cancer Metastases

Researchers at the Netherlands Cancer Institute have compiled a detailed catalog of bacteria living in cancer metastases.

10 Apr 2024

Understanding Prostate Cancer Disparities Through Proteogenomics

Certain proteogenomic signatures in the prostate cancers of men of African and European ancestries were associated with higher risk of metastasis and/or recurrence of the disease, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10.

10 Apr 2024

Nanoparticle-Based Therapy Shows Promise in Eradicating Tumors

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types.

28 Mar 2024

AI Predicts Multiple Protein Shapes, Boosting Drug Development

By understanding protein dynamics and functions, a group of academics at Brown University have devised a method for quickly predicting various protein configurations using machine learning.

28 Mar 2024

Bioinformatics Tool Recognizes Chromosome Changes in Cancer Cells

A group from IRB Barcelona and the University of Barcelona has created a novel bioinformatics instrument to recognize the chromosomal changes characteristic of cancerous cells.

22 Mar 2024

Machine Learning Accelerates Personalized T Cell Therapy Development for Cancer Patients

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

18 Mar 2024

Understudied Brain Cell Holds Key to Glioblastoma's Immunotherapy Resistance

Glioblastoma is one of the most treatment-resistant cancers, with those diagnosed surviving for less than two years.

13 Dec 2023

Non-Invasive Technology for the High-Throughput Characterization of Cancer Cells

Monitoring cancer cells effectively can help physicians with treatment and management, thus reducing cancer-related mortality.

11 Dec 2023

Exploring the Role of Extracellular Vesicles in Cellular Communication

A research project, jointly conducted by scientists affiliated with the Germans Trias i Pujol Research Institute, has uncovered the potential advantages of employing an agarose spot migration assay for assessing the capacity of extracellular vesicles to attract neighboring cells within a controlled setting.

1 Nov 2023