Nuclease News and Research

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Study Unlocks Mechanisms Behind Nucleosome Arrays Using Signal Theory and Machine Learning

Findings show that machine learning can accurately predict nucleosome positions, emphasizing the relationship between nucleosome architecture and gene activity.

17 Oct 2024

Mapping the Complex Structure and Function of CRISPR-Cas Protein Scissors

CRISPR-Cas systems help to protect bacteria from viruses. Several different types of CRISPR-Cas defense systems are found in bacteria, which differ in their composition and functions.

3 Oct 2024

Structural Discovery of Fanzor Proteins Offers New Directions in Genome Engineering

A revolution in biomedicine is currently underway, driven by the application of genome engineering tools such as the prokaryotic CRISPR-Cas9.

3 Oct 2024

Sae2 Regulates Critical DNA Repair Functions in Yeast

DNA damage is a cellular phenomenon that introduces structural abnormalities in double-stranded DNA. External factors, such as radiation or chemical agents, as well as internal factors, such as blocked DNA replication, can generate double-strand breaks (DSBs) in DNA.

29 Aug 2024

From CRISPR-Cas to Fanzor system: New frontiers in gene editing

The features of various CRISPR-Cas systems, including CRISPR-associated transposons (CASTs) and the eukaryotic equivalent of CRISPR-Cas systems, Fanzor systems.

9 Aug 2024

New CRISPR-Based Test Achieves Rapid Detection of Tuberculosis

The rapid detection of Mycobacterium tuberculosis, the etiological agent of tuberculosis.

1 Aug 2024

PUMA: A Breakthrough in CRISPR-Cas12 for RNA Biomarker Detection

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics.

17 Jul 2024

New Gene Editing Technique Outperforms Existing Therapies

Cystic fibrosis, a prevalent genetic disorder, leads to thick mucus accumulation in the lungs and other parts of the body, resulting in breathing difficulties and infections.

11 Jul 2024

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

Cryo-EM Study Reveals Cas7-11-CRISPR Complex Regulation Mechanisms

In a recent study published in Signal Transduction and Targeted Therapy, Chinese researchers studied the cryo-electron microscopy structures of the CRISPR-Cas7-11 nuclease, both alone and in complex with the regulatory protein tetratricopeptide repeat fused with Cas/(human enhancer of filamentation 1) HEF1-associated signal transducer (TPR-CHAT).

24 May 2024

Viruses Offer Efficient Delivery for Precise Plant Breeding

The application of genome editing in plant molecular breeding is hampered by the lack of straightforward and efficient methods for introducing genome editing reagents into plants, despite the technology's great potential.

20 May 2024

New Nanotool Detects Pathogens at a Fraction of the Cost

A team of researchers from The University of Texas at Austin, led by SMU nanotechnology expert MinJun Kim, developed a less costly method to detect nuclease digestion, one of the essential processes in many nucleic acid sensing applications, such as those used to identify COVID-19.

14 Feb 2024

Unlocking Precise DNA Modifications With Cas12a Innovations

Caixia Gao’s group at the Chinese Academy of Sciences’ Institute of Genetics and Developmental Biology has created a number of new prime editors based on the Cas12a protein, broadening the applications and targeting range of precision genome editing, as reported in a study published in Nature Biotechnology.

12 Jan 2024

Cryo-EM Analysis Uncovers Unexpected Enzymatic Switch in Bacterial Anti-Phage System

Scientists have revealed a never-before-seen phenomenon in a protein: Alone, the enzyme processes DNA and RNA but, when bound to another protein as part of a defense system, interacts with a completely different type of compound to help bacteria commit suicide.

14 Dec 2023