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Advanced Sequencing Uncovers Cause of Rare Mitochondrial Encephalopathy

Mitochondrial diseases are among the most prevalent hereditary metabolic disorders, known to occur in one out every 5000 births.

19 Nov 2024

A Landmark Study Reveals the Widespread Existence of DNA i-Motifs

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

30 Aug 2024

Gene Editing Creates Prickle-Free Eggplants for Easier Farming

Eggplants, a staple crop globally, present significant challenges in cultivation and harvesting due to their prickles. These prickles, which serve as a natural defense mechanism, complicate handling and reduce efficiency in agricultural practices. Addressing these issues is crucial for improving farming outcomes. Consequently, researchers are focused on understanding the genetic basis of prickle formation to develop prickle-free eggplant varieties. Based on these challenges, there is a pressing need to conduct in-depth research and identify solutions for more efficient eggplant cultivation.

9 Aug 2024

Advancing the Understanding of Circadian Regulation with Melanopsin DNA Aptamers

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

15 Jul 2024

Genomic Insights Into the Evolution of Gigantism in Cetaceans

Certain gene regions in cetaceans (whales, porpoises, and dolphins) play a role in explaining the remarkable size differences among species, such as the Blue whale (Balaenoptera musculus), which can reach lengths of up to 30 m – almost 10 m longer than a bus – in contrast to the Bottlenose dolphin (Tursiops truncatus), which typically reaches a maximum length of 4 m.

23 Jan 2024

Unlocking the Secrets of Bacterial Transcription

Bacterial transcription serves as an assembly line for duplicating genetic directives from double-stranded DNA into RNA molecules.

7 Nov 2023

New Mechanism of Cannibalism Discovered in Bacillus velezensis SQR9

When considering a bacterial population as a multicellular community, it is imperative to understand the inherent roles of maintaining homeostasis and viability in response to environmental factors.

3 Aug 2023

Essential Bacterial Signaling Autoproteolysis in C. thermocellum

Sensing and communicating with the extracellular environment are both aspects of transmembrane signaling.

24 Jul 2023

Analyzing the GmZF351 transgenic soybean plants and their stress tolerance

Across the globe, soybean is considered to be an important food, oil, and feed crop worldwide.

29 Mar 2023

Blending multiple maps uncover new genetic causes of blindness

In a new study, Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues discovered a new genetic risk factor for adult-onset macular degeneration (AMD) by combining a map of gene regulatory sites with disease-associated loci.

18 Jan 2023

New technique could help fine-tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.

2 Nov 2022

New technique controls gene activity without altering the DNA sequence of the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

7 Mar 2022

Researchers identify genes responsible for “spinach teeth”

People are generally familiar with “spinach teeth,” the harmless but gritty-chalky mouthfeel triggered because of a vegetable.

23 Dec 2021

New gene editing approach bypasses disease-causing mutations

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.

From Penn State University 22 Apr 2021

Researchers use CRISPR to tinker with corn kernel numbers

Corn--or maize--has changed over thousands of years from weedy plants that make ears with less than a dozen kernels to the cobs packed with hundreds of juicy kernels that we see on farms today. Powerful DNA-editing techniques such as CRISPR can speed up that process.

23 Feb 2021

Researchers examine cooperative tumorigenic effects of targeted deletions of tumor suppressors

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

12 Oct 2020

How Artificial Intelligence aids Gene Activation Discovery

Professor James Kadonaga speaks to AZoLifeSciences about his research into gene activation, and how artificial intelligence can help to aid its discovery.

From UC San Diego 18 Sep 2020

Epigenomic data can help characterize genes that play key role in cancer progression

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

From Massachusetts Institute of Technology (MIT) 24 Jul 2020

Study identifies complex functional, physical interactions between p53 gene and the INSR pathway

Volume 11, Issue 25 of @Oncotarget reported that the present study was aimed at evaluating the hypothesis that p53 governs the expression and activation of the INSR gene in breast cancer cells.

25 Jun 2020

Important genetic mechanism behind inflammatory bowel disease revealed

Researchers at Children's Hospital of Philadelphia have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease.

10 Apr 2020