Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

F-Actin Accumulation Impairs Brain Function in Aging Fruit Flies

Humans aren't the only ones who grow forgetful as they age -; fruit flies do, too. But because fruit flies have a lifespan of only about two months, they can be a useful model for understanding the cognitive decline that comes with aging.

29 Oct 2024

High-throughput screening identifies potential drugs for low-grade serous ovarian cancer

In a recent study, researchers used high-throughput drug screening to identify potential therapeutic targets and novel treatments for low-grade serous ovarian cancer (LGSOC), offering hope for more effective and personalized therapies.

26 Sep 2024

Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

14 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.

27 Dec 2023

New Drug-Like Molecule Enhances Mitophagy, Protects Against Neurodegeneration

Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.

14 Nov 2023

Revealing a Novel Signaling Pathway Fostering Aging-Related Chronic Metabolic Disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

4 Aug 2023

Combining Proteins With Nano-Based Engineering to Create Circuits

Penn State researchers have developed the first protein-based nano-computing agent that can be used as a circuit.

29 May 2023

Researchers Examine the Role of TOR in LR Formation and its Interplay with Auxin Signaling

Along with sugar reallocation, a basic molecular mechanism within plants controls the formation of new lateral roots. An international team of plant biologists has demonstrated that it is based on the activity of a certain factor, the target of rapamycin (TOR) protein. A better understanding of the processes that regulate root branching at the molecular level could contribute to improving plant growth and therefore crop yields, according to research team leader Prof. Dr Alexis Maizel of the Centre for Organismal Studies at Heidelberg University.

23 May 2023

New Mechanism Controlling Cellular Proliferation in Response to Serum Revealed

Researchers of the Genome Dynamics Project team at Tokyo Metropolitan Institute of Medical Science revealed new mechanism controlling cellular proliferation in response to serum, which triggers growth of resting cells.

13 Apr 2023

Cellular Recycling Function in the Brain Slows Dramatically After Traumatic Brain Injury

Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.

5 Apr 2023

Protecting normal cells from chemotherapy, while eliminating drug-resistant cancer cells

A new review paper was published in Oncotarget's Volume 14 on March 11, 2023, entitled, "Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells."

14 Mar 2023

New model simplifies the understanding of vascular malformations

Our bodies are made up of 60,000 miles of complex pipes that play a vital role in transporting nutrients throughout our bodies, performing waste disposal, and supplying our organs with fresh oxygen and blood.

27 Feb 2023

Versatile molecular toolbox expands the scope of gene regulation

Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.

15 Feb 2023

Waste disposal mechanism of mitochondria to remove mtDNA mutations

University of Cologne researchers have uncovered the mechanism by which cells can get rid of mutated mitochondrial DNA (mtDNA)—the heart of each of our cells, the mitochondria.

17 Nov 2022

Identifying the structure of the SEA complex

The mTOR protein is important for cell growth, proliferation, and survival. Its activity fluctuates according to nutrient availability and growth factors like hormones.

1 Nov 2022

Research associates autophagy and age-related nervous system degradation

The in-built mechanism of recycling dead or poisonous material to preserve the health of human cells is critical to general health.

20 Apr 2022

Insight into oligodendrocyte cells could lead to new treatments for neurodegenerative diseases

New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis-;and autoimmune disease that affects the brain and nervous system-;and allow for the development of better therapeutic treatments.

14 Mar 2022

Study results facilitate construction of complex nanoscale computing agents

Scientists for the first time developed a nano computing agent that regulates the function of a specific protein involved in cell movement and cancer metastasis.

From Penn State University 19 Nov 2021