Drug Discovery & Pharmaceuticals

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Substances from marine plants show promising results against Covid, says study

According to research by the University of the West of Scotland, antiviral drugs can be produced from earlier overlooked substances seen in marine plants.

17 Nov 2021

New visible-light-based approach to structurally modify bioactive molecules

Researchers have been working on new, sustainable techniques to synthesize chemicals by leveraging the inexhaustible, green energy of visible light.

10 Nov 2021

Biognosys Launches Next-Generation Blood Biomarker Discovery Solution

Biognosys today announces the launch of its next-generation blood biomarker discovery solution, which will be offered as a contract research service.

From Biognosys 10 Nov 2021

Experts identify novel mechanisms involved in macrophage polarization

Macrophages are important cells of the immune system with numerous beneficial functions. However, macrophages also aggravate common diseases.

8 Nov 2021

Multiple sclerosis drug improves memory in mouse model of Alzheimer's disease

Losing memory is a hallmark of Alzheimer's, a symptom of the disease that depletes a patient's quality of life. Improving memory and slowing cognitive changes caused by the disease is an ongoing challenge for researchers seeking to develop novel therapies.

8 Nov 2021

Research opens new therapeutic perspectives for treatment of skin fibrosis

Collagen, the main component of the skin's extracellular matrix, can cause a pathological condition if it is in excess. Applying an electric field to the skin affects collagen pathways, temporarily reducing collagen production and increasing its degradation.

22 Oct 2021

Targeted drug shows promise against brain metastases from kidney cancer

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

22 Oct 2021

Drug company pipelines are developing new molecules to help people safely shed extra weight

Drugs that promise to help people lose weight have had a checkered past, such as the infamous fen-phen that was pulled from the market in 1997 after reports of heart valve damage.

21 Oct 2021

Study provides insights on mucin degradation mechanisms by a group of gut bacteria

Recent research identified that a single sulfatase adds to the degradation of mucus that safeguards the intestinal lining.

13 Oct 2021

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

12 Oct 2021

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

Experts create “living medicine” to combat biofilms on medical implants

Scientists have developed the first “living medicine” to treat antibiotic-resistant bacteria thriving on medical implants’ surfaces.

8 Oct 2021

Multiple micronutrient supplements included in the WHO Model List of Essential Medicines

The New York Academy of Sciences today announced that multiple micronutrient supplements (MMS) have now been included in the World Health Organization's (WHO) Model List of Essential Medicines (known as EML), as an antenatal supplement for pregnant women.

6 Oct 2021

Common drug to treat cancer reverses Alzheimer’s symptoms in mice

A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new UBC research has found.

6 Oct 2021

Ketone supplement may be a new therapeutic strategy for enhancing brain health in adults with obesity

New research published in The Journal of Physiology has shown that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity.

5 Oct 2021

New datasets published to better train ML models for drug discovery

Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions. In a recent paper, researchers at GlaxoSmithKline (GSK) and the Cambridge Crystallographic Data Centre (CCDC) combined their proprietary (GSK) and published (CCDC) datasets to better train machine learning (ML) models to predict stable polymorphs to use in new drug candidates.

4 Oct 2021

Delta opioid receptor agonists modulate immune responses to ameliorate colonic inflammation

Opioids are a class of substances that control sensations such as pain and emotions in animals. While plant-derived opioid narcotics such as morphine are the most well-recognized, other opioid molecules like endorphins can also be synthesized by the body or artificially developed in laboratories.

From Tokyo University of Science 1 Oct 2021