Genomics

RSS

New study on genotype-phenotype associations sheds light on human complex traits, diseases

A new study analyzing the association between an individual's genetics (genotype) and their observable characteristics resulting from the interaction of genetics and the environment (phenotype), contributes new knowledge to the understanding of human complex traits and diseases.

2 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

Scientists develop new method that enables single-cell RNA sequencing in large number of cells

RNA sequencing is a powerful technology for studying cells and diseases. In particular, single-cell RNA sequencing helps uncover the heterogeneity and diversity of our body.

2 Jun 2021

Biologists use eDNA technique to find invasive snails

Invasive species, beware: Your days of hiding may be ending. Biologists led by the University of Iowa discovered the presence of the invasive New Zealand mud snail by detecting their DNA in waters they were inhabiting incognito.

2 Jun 2021

A gene that impacts the development of bone cancer in children discovered

Researchers have discovered a gene, OTUD7A, that impacts the development of Ewing sarcoma, a bone cancer that occurs mainly in children.

2 Jun 2021

Each city has its own exclusive microbiome, finds study

A new study performed by researchers report that each city has its own exclusive microbiome or a “fingerprint” of bacteria and viruses that uniquely identify it.

1 Jun 2021

Study examines if myoDN improves myoblast differentiation exacerbated by diabetes

Skeletal muscle makes up 30% to 40% of body weight and serves multiple functions like heat production and energy metabolism.

1 Jun 2021

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Scientists have come up with an innovative function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM).

1 Jun 2021

Genetic differences within microalgal symbionts relate to the coral species they inhabit

The microscopic algae that live inside and provide nutrients to their reef-building coral hosts may be evolving in tandem with the corals they inhabit, so each partner is fine-tuned to meet one another's needs.

From Penn State University 1 Jun 2021

New study shows why some children get secondary leukemia after neuroblastoma treatment

Researchers from the Wellcome Sanger Institute and the University of Cambridge discovered that in children with neuroblastoma—a tumor of immature nerve cells—platinum chemotherapy created mutations in the genome that might lead to leukemia in some children later on.

31 May 2021

Genetic editing tools stop the spread of Culex mosquitoes

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

From UC San Diego 31 May 2021

Non-specific lipid transfer proteins help improve wheat tolerance

Fusarium Head Blight (FHB), often called scab, is a serious disease of small grain cereals like barley and wheat that affects farmers worldwide.

27 May 2021

Researchers discover new genes and functionalities in bovine genome

Modern genetic research often works with what are known as reference genomes. Such a genome comprises data from DNA sequences that scientists have assembled as a representative example of the genetic makeup of a species.

27 May 2021

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

Human-driven global change is challenging the scientific community to understand how marine species might adapt to predicted environmental conditions in the near-future (e.g. hypoxia, ocean warming, and ocean acidification).

27 May 2021

New software tool detects, evaluates, and quantifies off-target editing activity

CRISPR technology enables researchers to edit genomes by modifying DNA sequences and hence gene function.

27 May 2021

Two components of bacterial CRISPR-Cas immunity system are physically linked

Skoltech scientists have demonstrated that the two components of the bacterial CRISPR-Cas immunity system are physically connected.

27 May 2021

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.

25 May 2021

Study could help develop peptide siRNA carrier for human oral cancer

MUSC Hollings Cancer Center researchers are exploring the use of peptide carriers for the delivery of small RNA drugs as a novel treatment for cancer. The team's recent work, published online March 19 in the Molecular Therapy - Nucleic Acids journal, lays the foundation for developing a clinically relevant peptide carrier RNAi-based drug treatment strategy for human oral cancer.

25 May 2021

New method helps tests large groups for SARS-CoV-2 infection

Researchers at the Vienna BioCenter designed a testing protocol for SARS-CoV-2 that can process tens of thousands of samples in less than 48 hours. The method, called SARSeq, is published in the journal Nature Communications and could be adapted to many more pathogens.

25 May 2021

Genomics

New study on genotype-phenotype associations sheds light on human complex traits, diseases

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Understanding molecular determinants of liver cancer in patients with Indigenous American ancestry

Scientists develop new method that enables single-cell RNA sequencing in large number of cells

Biologists use eDNA technique to find invasive snails

A gene that impacts the development of bone cancer in children discovered

Each city has its own exclusive microbiome, finds study

Study examines if myoDN improves myoblast differentiation exacerbated by diabetes

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Genetic differences within microalgal symbionts relate to the coral species they inhabit

New study shows why some children get secondary leukemia after neuroblastoma treatment

Genetic editing tools stop the spread of Culex mosquitoes

Non-specific lipid transfer proteins help improve wheat tolerance

Researchers discover new genes and functionalities in bovine genome

Genomic study can reveal adaptive mechanisms of life under future ocean acidification

New software tool detects, evaluates, and quantifies off-target editing activity

Two components of bacterial CRISPR-Cas immunity system are physically linked

Genetic and molecular mechanisms make chemotherapy drug work for some cancer patients

Study could help develop peptide siRNA carrier for human oral cancer

New method helps tests large groups for SARS-CoV-2 infection

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Latest in Genomics