Genomics

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Study shows 1 in 8 cancer patients had inherited cancer-related gene mutation

Genetic testing can uncover inherited genetic mutations, and could individualize cancer therapies, improve survival, manage cancer in loved ones and push the boundaries of precision medicine.

3 Nov 2020

Study identifies genes and molecular pathways most sensitive to chemical exposures

A University of Massachusetts Amherst environmental health scientist has used an unprecedented objective approach to identify which molecular mechanisms in mammals are the most sensitive to chemical exposures.

30 Oct 2020

Researchers find genetic correlations between inflammatory bowel disease and stress, depression

Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression.

30 Oct 2020

Severe ulcerative colitis linked to newly-discovered strain of oral bacteria

Severe ulcerative colitis - a form of inflammatory bowel disease (IBD) - has been linked to a newly-discovered strain of oral bacteria, a study led by UNSW Sydney has found.

From The University of New South Wales (UNSW) 30 Oct 2020

Scientists reveal molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

Scientists sequence full genome of ornamental variety of miscanthus

An international research team has sequenced the full genome of an ornamental variety of miscanthus, a wild perennial grass emerging as a prime candidate for sustainable bioenergy crops.

30 Oct 2020

Researchers develop RNA catalyst that sheds light on evolution

Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes.

29 Oct 2020

Study shows how cancer remodels human chromosomes for its own purposes

Scientists have shown that cancer rebuilds the architecture of human chromosomes, which allows the disease to take hold and spread.

28 Oct 2020

Study shows genetic analysis with RNA sequencing can increase diagnostic yield

In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis.

28 Oct 2020

Study sheds new light on penicillin allergy

Scientists have reported the first strong evidence of the role of HLA-B, a crucial histocompatibility complex gene, in penicillin allergy.

27 Oct 2020

Researchers develop new sensors to detect gene activity

A team of researchers have developed genetic sensors that are capable of detecting the activity of genes, instead of only the genes themselves.

From The University of Warwick 27 Oct 2020

Proviral and antiviral genes may help develop new therapies for COVID-19

Scientists have screened an unlimited number of cells exposed to the COVID-19 virus and detected genes that appear to close the door on the virus.

27 Oct 2020

Anti-inflammatory mediator could play key role in wound healing

"Wound healing is one of the most complex biological processes," writes Professor Kazumitsu Sugiura and Dr Kenta Saito from Fujita Health University, Japan, in their article recently published in Nature's Scientific Reports.

27 Oct 2020

Researchers identify genes associated with autism spectrum disorder

The lack of some genes in the BEC/TCEAL cluster could be related to some alterations associated with the autism spectrum disorder, according to a preclinical study published in the journal Genome Biology, and led by Professor Jordi Garcia Fernàndez, from the Faculty of Biology and the Institute of Biomedicine of the University of Barcelona (IBUB), and researcher Jaime Carvajal, from the Andalusian Centre for Developmental Biology - University Pablo de Olavide (CSIC-UPO).

27 Oct 2020

Study shows potential avenues of COVID-19 vulnerability in patients with diabetic kidney disease

People with diabetes -- especially the 20 to 40 percent with diabetic kidney disease -- are among the most at risk for serious complications and death from COVID-19.

27 Oct 2020

Increased weight is causally protective for breast and prostate cancer

Although a recent campaign by Cancer Research UK emphasized obesity as a risk factor for cancer on par with smoking, the scientific literature on the relationship between increased weight and cancer risk is not so clear.

27 Oct 2020

Researchers identify new potential therapeutic targets for SARS-CoV-2 infection

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020