Genomics

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Using genetic engineering to study evolutionary assimilation of foreign DNA in a new host

All life is subject to evolution in the form of mutations that change the DNA sequence of an organism's offspring, after which natural selection allows the 'fittest' mutants to survive and pass on their genes to future generations.

11 Aug 2020

Researchers use genome editing to facilitate drug discovery based on natural fungus

Rice University scientists have won federal support for their pursuit of novel drugs to treat human disease.

11 Aug 2020

Researchers describe a previously unknown phylum of aquatic Archaea

In a publication in Nature Communications last Friday, NIOZ scientists Nina Dombrowski and Anja Spang and their collaboration partners describe a previously unknown phylum of aquatic Archaea that are likely dependent on partner organisms for growth while potentially being able to conserve some energy by fermentation.

11 Aug 2020

$1.2 million NIH grant awarded to create humanized mice susceptible to COVID-19

The National Institutes of Health has awarded a grant of $1.2 million to the Mouse Biology Program at the University of California, Davis, to create mice that are susceptible to the COVID-19 virus, and to distribute them to researchers.

11 Aug 2020

Gene therapy to the inner retina prevents blindness in Cln3-deficient mice

Gene therapy to the inner retina prevented blindness in a mouse model of the neuro-degenerative disorder CLN3 Batten disease.

11 Aug 2020

Study may reduce transmissible cancer in Tasmanian devils, offers hope for treating human cancers

A rare, transmissible tumor has brought the iconic Tasmanian devil to the brink of extinction, but new research by scientists at Washington State University and the Fred Hutchinson Cancer Research Center in Seattle indicates hope for the animals' survival and possibly new treatment for human cancers.

10 Aug 2020

Increased blood lead levels in children are linked to reduced expression of genes

Researchers have revealed a connection between methylation of genes implicated in heme synthesis and carcinogenesis and high blood lead levels in children, signifying a previously unfamiliar mechanism for lead poisoning.

10 Aug 2020

Study shows how DNA from ancient ancestors was passed down to modern humans

According to a new study of ancient genomes, different branches of the human family tree could have interbred numerous times, and certain human beings carry DNA from an unfamiliar and ancient ancestor.

7 Aug 2020

Study could advance the field of beef production

While it's long been said "you are what you eat," a team of animal scientists in the University of Tennessee Institute of Agriculture is taking an in-depth look at how what you are is influenced by your ability to eat, at least in cattle.

7 Aug 2020

4D optical coherence tomography offers insight into embryonic heart development

How a valveless embryonic heart tube pumps blood is a long-standing scientific mystery. Thanks to innovations in light-based technology, fresh insights are now available into the biomechanics of mammalian cardiogenesis-;and in particular, the pumping dynamics of the mammalian tubular embryonic heart.

7 Aug 2020

Study: Amyloid-beta alters cholesterol biosynthesis in early stages of Alzheimer’s

Korea Brain Research Institute (headed by Suh Pann-ghill) announced on July 24 the discovery that an increase in amyloid-beta in the brain alters cholesterol biosynthesis, which was found by Dr. Cheon Mookyung of KBRI through RNA-seq analysis data (omics) using AI.

7 Aug 2020

Genes linked to Down syndrome abnormalities may offer protection against solid tumors

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that a set of genes with decreased expression in individuals with Down syndrome may lead to clinical abnormalities in this population, such as poor muscle development and heart valve problems.

6 Aug 2020

Researchers discover genetic cause of severe auto inflammatory syndrome

Researchers from the Icahn School of Medicine used a novel genetic sequencing technology to identify the genetic cause of--and a treatment for--a previously unknown severe auto inflam-matory syndrome affecting an 18-year-old girl since infancy.

5 Aug 2020

Scientists explore the role of epigenetic regulator factors in embryonic development

A research team at the Max Planck Institute for Molecular Genetics in Berlin has explored the role of factors in embryonic development that do not alter the sequence of DNA, but only epigenetically modify its "packaging".

5 Aug 2020

New findings help to better understand the genetics of neuropsychiatric disorders

A new study led by NorthShore University HealthSystem (NorthShore) and the University of Chicago took a novel approach to identifying SNPs influencing the risk of neuropsychiatric disorders like schizophrenia, bipolar and major depressive disorder, the institutions announced today.

5 Aug 2020

Newly discovered 'mutation fog' linked to normal DNA repair process

Hypermutation is an unusual occurence that can lead to many nearby mutations at once, severely damaging our genetic material and potentially causing cancer.

5 Aug 2020

New method reveals the dynamics of cell development and gene activity

Studies on cellular dynamics are vital to interpret the development of cells and the progression of various diseases.

5 Aug 2020

New study may offer a novel, potential target for treating breast cancer

According to researchers, G-quadruplexes have been demonstrated to play a crucial role in specific types of breast cancer for the first time.

5 Aug 2020

Study uncovers molecular mechanism of metabolite-mediated epigenome involved in organismal aging

Scientists have recently demonstrated that acetyl-CoA connects mitochondrial stress to the nuclear epigenome through the NuRD complex.

4 Aug 2020

Hudsonalpha researchers help elucidate functional elements of the genome

Although the Human Genome Project sequenced a nearly-complete human genome almost 20 years ago, only about two percent of the genes in the human genome have been extensively studied and identified as protein-coding genes. Proteins form the basis of living tissues and play a central role in biological processes.

3 Aug 2020

Genomics

Using genetic engineering to study evolutionary assimilation of foreign DNA in a new host

Researchers use genome editing to facilitate drug discovery based on natural fungus

Researchers describe a previously unknown phylum of aquatic Archaea

$1.2 million NIH grant awarded to create humanized mice susceptible to COVID-19

Gene therapy to the inner retina prevents blindness in Cln3-deficient mice

Study may reduce transmissible cancer in Tasmanian devils, offers hope for treating human cancers

Increased blood lead levels in children are linked to reduced expression of genes

Study shows how DNA from ancient ancestors was passed down to modern humans

Study could advance the field of beef production

4D optical coherence tomography offers insight into embryonic heart development

Study: Amyloid-beta alters cholesterol biosynthesis in early stages of Alzheimer’s

Genes linked to Down syndrome abnormalities may offer protection against solid tumors

Researchers discover genetic cause of severe auto inflammatory syndrome

Scientists explore the role of epigenetic regulator factors in embryonic development

New findings help to better understand the genetics of neuropsychiatric disorders

Newly discovered 'mutation fog' linked to normal DNA repair process

New method reveals the dynamics of cell development and gene activity

New study may offer a novel, potential target for treating breast cancer

Study uncovers molecular mechanism of metabolite-mediated epigenome involved in organismal aging

Hudsonalpha researchers help elucidate functional elements of the genome

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