Genomics

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A Novel Technique for Ribonucleotide Quantification

Scientists at the Folkhälsan Research Center have devised a novel technique enabling the straightforward quantification of ribonucleotides in small tissue and cell samples within a standard laboratory setting, without the need for specialized equipment.

28 Nov 2023

FLSHclust Unveils 188 Novel CRISPR-Associated Gene Modules

Employing a groundbreaking algorithm named FLSHclust (“flash clust”), scientists have unearthed 188 uncommon and previously undiscovered CRISPR-associated gene modules, among billions of protein sequences. This includes the identification of a novel type VII CRISPR-Cas system.

24 Nov 2023

Novel Perspectives on Human Genetics in Digestive Diseases

The entire Y chromosome has been decoded, which represents a significant advancement in human genetics and creates new opportunities for studying digestive diseases.

24 Nov 2023

Tapping into the Genetic Reservoir of Wild Blueberries

Blueberries, belonging to the Vaccinium genus and characterized by their petite size, are renowned for their delectable flavor, harmonious blend of sweetness and acidity, and impressive nutritional profile. They are rich in a diverse array of vitamins and antioxidants.

23 Nov 2023

Unraveling the Molecular Basis of SIDT1 and SIDT2 in C. elegans

New work thoroughly characterizes the structural features of human SIDT1 and SIDT2, revealing their existence as dimers in vitro and their tendency to form dimers or higher-order oligomers in their natural environment.

23 Nov 2023

New Optical Tweezers Open Up New Insights on Specific DNA Motor Proteins

Using “optical tweezers” driven by lasers, researchers have discovered a universal motor mechanism that viruses utilize to package their DNA into infectious particles.

22 Nov 2023

How 3D-Printed Organs Could Reduce Use of Animal Testing in Medical Research

In the realm of scientific research, particularly in the medical and pharmaceutical sectors, animal testing has been a prevalent method.

22 Nov 2023

Insights Into the Genetic Landscape of Human Head Shape

A collaborative research team from the University of Pittsburgh and KU Leuven has identified a set of genes that influence the shape of the human head.

20 Nov 2023

New Method Removes Background Noise from CITE-Seq Data

Researchers from the Chobanian & Avedisian School of Medicine and the College of Arts & Sciences at Boston University have devised an innovative tool to address this limitation. This tool can discern and eliminate undesirable background noise originating from various sources, enhancing the precision of analysis in CITE-seq experiments.

20 Nov 2023

Scientists Discover New Class of Molecular Glue Degraders for Cancer Therapy

Cells contain molecular machinery that targets and disposes of unwanted proteins to maintain homeostasis.

17 Nov 2023

Gene Splicing Affects CD20 Expression and Response to Cancer Immunotherapy

Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated.

17 Nov 2023

Study Uncovers Ancestry-Specific Genetic Factors in IBD

The advent of whole genome sequencing technology has prompted an explosion in research into how genetics are associated with disease risk.

17 Nov 2023

New Model Reveals How Cells Maintain Epigenetic Memory During Cell Division

Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.

17 Nov 2023

Wilmot Researchers Uncover a "Genomic Tug of War" That Influences Decitabine's Effectiveness

Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time.

17 Nov 2023

The Link Between Tumor Cell Mutations and DNA-RNA Hybrids

New research indicates that chromatin and its regulatory factors play a crucial role in preventing the formation of DNA-RNA hybrids, which are linked to genomic instability and cancer.

17 Nov 2023

Circular Extrachromosomal DNA Linked to Medulloblastoma Relapse and Death

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA-;loops of DNA found outside of regular chromosomes-;are twice as likely to relapse and three times as likely to die within five years of diagnosis.

15 Nov 2023

Rare Genetic Variant Found to Protect Against Alzheimer's Disease

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

14 Nov 2023

Scientists Identify 4,749 Gene Clusters Linked to Cancer Prognosis

Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.

14 Nov 2023

LJI Scientists Uncover New Superpower of MAIT Cells

Scientists at La Jolla Institute for Immunology (LJI) are investigating a talented type of T cell.

13 Nov 2023

Quantum Biology and AI Improve CRISPR Cas9 Efficiency in Microbes

Scientists at Oak Ridge National Laboratory used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.

10 Nov 2023