Genomics

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Locating genes involved in the metabolism and distribution of human fat

Researchers from the University of Minnesota Medical School and the University of Chicago discovered data identifying “jumping genes”—associated with the distribution of fat in the abdomen—that are connected to a higher risk for health problems from obesity in women.

17 Feb 2023

Improved efficacy of advanced genome editing with machine learning

Researchers at the Wellcome Sanger Institute have developed a new tool to estimate the probability of successfully introducing a gene-edited DNA sequence into a cell’s genome using the prime editing method.

17 Feb 2023

High diversity in T-cell receptor genes explains diverse response to infections

Researchers from Karolinska Institutet have demonstrated that the genes that encode the T cell receptors change significantly between individuals and communities, which could help explain why people react differently to certain diseases.

17 Feb 2023

Researchers reveal link immune system genetics and a person's ability to resist new COVID-19 variants

An international team including researchers from the HSE University Faculty of Biology and Biotechnology has found a link between certain genetic features of the immune system and one's ability to effectively resist new waves of COVID-19.

17 Feb 2023

New insights into genetics of sexually dimorphic fat distribution in humans

Obesity causes many health problems and worsens several chronic illnesses, including type 2 diabetes and cardiovascular disease, however, some obese people are more susceptible to complications than others.

17 Feb 2023

NIH researchers release new tool to assemble complete genome sequences on-demand

National Institutes of Health researchers have developed and released an innovative software tool to assemble truly complete (i.e., gapless) genome sequences from a variety of species.

17 Feb 2023

AutoPLP helps detect mutating pathogenic variants quickly and accurately

As we now know from our experience with the COVID-19 pandemic, the microbes responsible for some infections can rapidly mutate into variants that evade detection and treatment.

16 Feb 2023

New approach to rapidly determine biological aging

Telomeres-;the caps at the ends of chromosomes that protect our genetic materials from the brunt of cellular wear and tear-;are known to shorten and fray over time.

16 Feb 2023

Scientists correct limb length in mouse model of autosomal dominant Robinow Syndrome

Robinow Syndrome is the best known of a set of genetic disorders that affect the growth and development of the skeletal system.

16 Feb 2023

Researchers construct the first chromosome-scale reference genome of Plantago ovata

Scientists have for the first time constructed the reference genome for the source of the popular fiber supplement, psyllium husk, which could boost supplies of the versatile plant-derived product.

16 Feb 2023

Novel approach removes the barriers of lifesaving cancer genetic services

Genetic counseling and genetic testing for mutations in certain genes such as BRCA1 and BRCA2 genes -; can help people understand their risk of certain types of cancer that can run in families, and improve outcomes through prevention, early detection, and targeted treatments.

16 Feb 2023

Versatile molecular toolbox expands the scope of gene regulation

Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.

15 Feb 2023

Study charts seasonal and circadian genetic variation across the human body

The daily rotation of Earth and its yearly voyage around the Sun marks the natural rhythm of life on the planet.

14 Feb 2023

Study finds similar levels of DNA damage in vapers and smokers

E-cigarettes-; used regularly by more than 10% of U.S. teens and more than 3% of adults-; were once pitched as a healthy alternative to tobacco cigarettes.

14 Feb 2023

UChicago scientists shed light on the longstanding puzzle of RNA methylation

University of Chicago scientists have discovered a new wrinkle in our understanding of how our genes work.

14 Feb 2023

Research provides insight into the regulation of heartbeats

UT Southwestern Medical Center researchers have mapped gene control elements in specialized cardiac cells responsible for coordinating heartbeats. The findings of the genome exploration study, published in The Journal of Clinical Investigation, provide insight into how heartbeats are regulated and could impact diagnosis and risk prediction for a variety of common arrhythmias.

14 Feb 2023