Genomics

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Blending multiple maps uncover new genetic causes of blindness

In a new study, Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues discovered a new genetic risk factor for adult-onset macular degeneration (AMD) by combining a map of gene regulatory sites with disease-associated loci.

18 Jan 2023

New toolkit enables researchers to map an individual’s RNA data to a much richer reference

Examining the gene expression of a person needs mapping the RNA landscape to a standard reference. This is done to gain an understanding of the degree to which genes are “turned on” and execute the functions in the body.

From University of California Santa Cruz 18 Jan 2023

Role of clonal hematopoiesis as a broad driver of atherosclerosis

A group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), collaborating with institutions in the USA, has shown that acquired mutations in the gene encoding the protein p53 contribute to the onset of atherosclerotic cardiovascular disease.

18 Jan 2023

Detecting the extent of natural selection over time

Institut Pasteur, Université Paris Cité, the CNRS, and the Collège de France researchers have employed paleogenomics to trace 10,000 years of human immune system evolution. They examined the genomes of over 2,800 individuals who lived in Europe over the past 10 millennia.

From Institut Pasteur 18 Jan 2023

Electrochemical biosensor for detecting antibodies

Although it frequently necessitates a challenging laboratory procedure, the quantitative detection of specific antibodies in complex samples like blood can provide information on a variety of diseases.

18 Jan 2023

Insights into the role of the germline in de novo mutation

The male reproductive system is a hotspot for the introduction of new genes. Perhaps that might assist in understanding why fathers tend to pass on more new mutations than mothers do. However, it does not explain why older fathers pass on more mutations than younger fathers.

16 Jan 2023

Ten years and 1,000 studies later, epigeneticists discover problems in their arsenal

Twenty years ago, following the initial sequencing of the human genome, geneticists started carrying out extensive genome-wide association studies to find genomic regions connected to human disease.

16 Jan 2023

Quicker and affordable method of extracting DNA from elephant dung

With the aid of a novel DNA-collection technique, researchers can now collect genetic data from elephants without endangering the animals or endangering themselves.

16 Jan 2023

Key genes driving cleft lip and palate identified

A research group headed by the University of Iowa recognized three genes that, when deleted, produce cleft lip or palate, a facial abnormality that affects around one in every 1,600 babies in the United States, according to the US Centers for Disease Control and Prevention.

13 Jan 2023

Analyzing the regulatory mechanisms of enzyme production in mold

Filamentous fungi have long been a close ally of sake brewers, but they may soon become associates of environmentalists as well. Scientists from Osaka Metropolitan University discovered the regulatory mechanisms of enzyme synthesis in a filamentous fungus, allowing for the effective degradation of plant biomass, an alternative energy resource to petroleum.

11 Jan 2023

New molecular profile of endometriosis to help improve therapeutic options

At Cedars-Sinai, a special and elaborate molecular profile of endometriosis has been engineered by investigators to help enhance therapeutic options for the millions of women suffering from the disease.

11 Jan 2023

New gene helps drive the development of the common lung cancer type

At the NYU Langone Health’s Perlmutter Cancer Center, a team headed by scientists has determined a gene that forces the development of the second most common type of lung carcinoma.

From New York University (NYU) 11 Jan 2023

Chilling tolerance trait in rice with the codon repeats at a single site

A recent study performed by Professor Chong Kang’s group from the Institute of Botany of the Chinese Academy of Sciences (CAS) has disclosed a fact that a novel cold domesticated repair mechanism for DNA damage in rice.

11 Jan 2023

Taste trumps everything, despite some hesitation about gene-edited table grapes

Despite some hesitation about gene-edited foods, taste trumps everything, according to a Washington State University-led survey of U.S. consumers.

10 Jan 2023

Broccoli heads can resemble cauliflower when grown in higher temperatures

As seasoned gardeners know, broccoli heads don't develop properly and can resemble cauliflower when grown in higher temperatures.

10 Jan 2023

Scandinavian gene pool development via DNA analysis

The complex relationships between geography, ancestry, and gene flow in Scandinavia are resolved in a new study based on 297 ancient Scandinavian genomes that were analyzed along with the genomic data of 16,638 modern Scandinavians.

6 Jan 2023

Researchers expand the known defensive abilities of CRISPR–Cas systems

Viruses can infect bacteria and archaea, just as they can humans. These microbes have evolved their own immune defense mechanisms to combat their pathogens. Bacterial defenses, like CRISPR-Cas systems, contain a variety of proteins and functions that aid bacteria in protecting themselves from foreign intruders.

5 Jan 2023

Discovery of a new cellular element crucial to sense of smell

Researchers at Umeå University have found an organelle, a previously unidentified cellular component, inside the neurons that are responsible for the ability to smell. The finding might have repercussions for future studies on COVID-19 symptoms like impaired smell sense.

5 Jan 2023

First-ever chromosome-level genome sequences completed for sharks

The first chromosome level genome sequences for great hammerhead and shortfin mako sharks have shown that both species have experienced major population declines over a 250,000-year history.

5 Jan 2023

Performing grafting and mobile CRISPR for genome editing in plants

An innovative twist to the CRISPR tool—also known as “genetic scissors”—is being utilized to edit plant genomes by researchers from the Max Planck Institute of Molecular Plant Physiology, signaling a methodology change.

4 Jan 2023