Histology & Microscopy

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Cryo-EM Reveals CDCA7's Hemimethylation Sensing in Nucleosome Core Particles

DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism. Disruptions in the standard DNA methylation patterns can lead to immunodeficiency and diseases such as cancer.

27 Aug 2024

New Imaging Technique Offers Clearer View of Brain Function

Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution. By imaging much faster and with less harm to brain tissue than traditional two-photon microscopy, the new approach could provide a clearer view of how neurons communicate in real time, leading to new insights into brain function and neurological diseases.

16 Aug 2024

New ProDOL Technique Revolutionizes Protein Counting in Living Cells

Scientists have developed a new way of counting labeled proteins in living cells that could become a standard and valuable tool in the field of biomedical research.

12 Aug 2024

New Microscope Peels Back Layers of Cellular Mystery

What does the inside of a cell really look like? In the past, standard microscopes were limited in how well they could answer this question. Now, researchers from the Universities of Göttingen and Oxford, in collaboration with the University Medical Center Göttingen (UMG), have succeeded in developing a microscope with resolutions better than five nanometers (five billionths of a meter). This is roughly equivalent to the width of a hair split into 10,000 strands. Their new method was published in Nature Photonics.

9 Aug 2024

Discovery of Novel Macrophage Population Offers Hope for Lung Repair Post-Viral Infection

Researchers at the University of Liège (Belgium) have discovered a new population of macrophages, important innate immune cells that populate the lungs after injury caused by respiratory viruses.

5 Aug 2024

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

2 Aug 2024

Novel Microscopy Method Revolutionizes Imaging with Reduced Radiation and Faster Results

An international team of scientists, led by Trinity College Dublin, has devised an innovative imaging method using state-of-the-art microscopes that significantly reduces the time and radiation required.

1 Aug 2024

Probing Plasma Membrane Dynamics with Cryo-Electron Microscopy

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood.

25 Jul 2024

Novel ATP Imaging System Reveals Insights into Kidney Energy Metabolism

The prevalence of kidney disease has been increasing in Japan, with it now affecting one in eight adults, but developing effective treatment remains a challenge.

24 Jul 2024

High Performance SEM Helps Drive NZ Towards a Smart, Green Future

The existing electron microscopy capabilities have been improved with the installation of a TESCAN CLARA Scanning Electron Microscope (SEM).

24 Jul 2024

Breakthrough Study Reveals How Toxoplasma gondii Alters Host Cell Metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

Real-Time Snapshots of RNA Polymerase Illuminate Transcription Bubble Dynamics

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.

10 Jul 2024

Are Advances in AI Technology Transforming Immunohistochemistry Analysis in Pathology?

The platforms and AI-based programs that are being used to analyze immunohistochemical markers and interpret the results.

3 Jul 2024

Bridge RNA: The Revolutionary Tool in Genetic Recombination

In a leap forward for genetic engineering, a team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way.

27 Jun 2024

Fruit Fly Motor Circuitry Revealed Through Advanced Mapping Techniques

Work is underway on a wiring diagram of the motor circuits in the central nervous system that control muscles in fruit flies.

27 Jun 2024

Breakthrough in Understanding Connexin-Drug Interactions

Researchers have gained new knowledge of how drugs bind to connexin molecules. These molecules form channels that allow neighboring cells to send direct messages to one another.

27 Jun 2024

Understanding Collective Cell Behavior in Constrained Environments

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks.

20 Jun 2024

Specific Population of "Time Cells" Found to be Essential for Learning Complex Behaviors

A sense of time is fundamental to how we understand, recall, and interact with the world.

19 Jun 2024

Breakthrough Imaging Reveals the Dynamics of the Brain's Fast-Acting Kainate Receptor

New groundbreaking images of one of the brain's fastest-acting proteins are providing critical clues that may lead to the development of targeted therapies to treat epilepsy and other brain disorders.

18 Jun 2024

Bacterial Buckling: Filamentous Cyanobacteria Bend Under Pressure

Filamentous cyanobacteria buckle at a certain length when they encounter an obstacle. This was discovered by the research group of Stefan Karpitschka, group leader at the Max Planck Institute for Dynamics and Self-Organization and professor at the University of Konstanz.

17 Jun 2024

Histology & Microscopy

Cryo-EM Reveals CDCA7's Hemimethylation Sensing in Nucleosome Core Particles

New Imaging Technique Offers Clearer View of Brain Function

New ProDOL Technique Revolutionizes Protein Counting in Living Cells

New Microscope Peels Back Layers of Cellular Mystery

Discovery of Novel Macrophage Population Offers Hope for Lung Repair Post-Viral Infection

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

Novel Microscopy Method Revolutionizes Imaging with Reduced Radiation and Faster Results

Probing Plasma Membrane Dynamics with Cryo-Electron Microscopy

Novel ATP Imaging System Reveals Insights into Kidney Energy Metabolism

High Performance SEM Helps Drive NZ Towards a Smart, Green Future

Breakthrough Study Reveals How Toxoplasma gondii Alters Host Cell Metabolism

Real-Time Snapshots of RNA Polymerase Illuminate Transcription Bubble Dynamics

Are Advances in AI Technology Transforming Immunohistochemistry Analysis in Pathology?

Bridge RNA: The Revolutionary Tool in Genetic Recombination

Fruit Fly Motor Circuitry Revealed Through Advanced Mapping Techniques

Breakthrough in Understanding Connexin-Drug Interactions

Understanding Collective Cell Behavior in Constrained Environments

Specific Population of "Time Cells" Found to be Essential for Learning Complex Behaviors

Breakthrough Imaging Reveals the Dynamics of the Brain's Fast-Acting Kainate Receptor

Bacterial Buckling: Filamentous Cyanobacteria Bend Under Pressure

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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