Histology & Microscopy

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Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

14 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

Lung Organoids Shed Light on Pseudomonas aeruginosa's Invasive Tactics

How do pathogens invade the lungs? Using human lung microtissues, a team at the Biozentrum of the University of Basel has uncovered the strategy used by a dangerous pathogen.

11 Jun 2024

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

Study Finds Essential Role of Orco Protein in Ant Olfactory Neuron Survival and Social Interaction

While smell plays a considerable role in the social interactions of humans-;for instance, signaling fear or generating closeness-;for ants, it is vitally important.

10 Jun 2024

Cellular Architecture Dictates T Cell Fate in Immune Response

Cellular Architecture Dictates T Cell Fate in Immune Response

From the outside, most T cells look the same: small and spherical. Now, a team of researchers led by Berend Snijder from the Institute of Molecular Systems Biology at ETH Zurich has taken a closer look inside these cells using advanced techniques.

7 Jun 2024

New mosTF Microscopy System Enhances Real-Time Brain Plasticity Research

New mosTF Microscopy System Enhances Real-Time Brain Plasticity Research

The brain's ability to learn comes from "plasticity," in which neurons constantly edit and remodel the tiny connections called synapses that they make with other neurons to form circuits.

6 Jun 2024

New Microscopy Reveals Secrets of SARS-CoV-2 Replication

New Microscopy Reveals Secrets of SARS-CoV-2 Replication

Recent research published in Nature Communications by a Stanford University team may provide more accuracy in drug development by examining at the nanoscale how the SARS-CoV-2 virus replicates in cells.

4 Jun 2024

Cryo-EM Reveals Structural Insights Into ADAM17/iRhom2 Complex

Cryo-EM Reveals Structural Insights Into ADAM17/iRhom2 Complex

Efficient communication between cells is vital for many biological processes, such as recruiting immune cells to combat disease.

24 May 2024

Plectasin's Velcro-Like Binding Holds Promise for Fighting Antimicrobial Resistance

Plectasin's Velcro-Like Binding Holds Promise for Fighting Antimicrobial Resistance

A small antibiotic called plectasin uses an innovative mechanism to kill bacteria. By assembling into large structures, plectasin latches onto its target on the bacterial cell surface comparable to how both sides of Velcro form a bond.

24 May 2024

Exploring the Evolution of Mitosis: Lessons from Close Relatives of Fungi and Animals

Exploring the Evolution of Mitosis: Lessons from Close Relatives of Fungi and Animals

Cell division is one of the most fundamental processes of life. From bacteria to blue whales, every living being on Earth relies on cell division for growth, reproduction, and species survival.

23 May 2024

Unlocking the Secrets of Selective Pollen Attraction in Flowers

Unlocking the Secrets of Selective Pollen Attraction in Flowers

A team of scientists from Nagoya University in Japan employed a sophisticated microscopic technology to study the internal reproductive mechanism of the Arabidopsis plant.

22 May 2024

Brookhaven Scientists Unravel Evolutionary Origins of Plant Lignin

Brookhaven Scientists Unravel Evolutionary Origins of Plant Lignin

Scientists from the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected.

20 May 2024

Bristle Biogenesis of Platynereis dumerilii: Microvilli as Nature's 3D Printers

Bristle Biogenesis of Platynereis dumerilii: Microvilli as Nature's 3D Printers

A new interdisciplinary study led by molecular biologist Florian Raible from the Max Perutz Labs at the University of Vienna provides exciting insights into the bristles of the marine annelid worm Platynereis dumerilii.

14 May 2024

UCLA Study Reveals Novel Mechanism for Memory Formation During Sleep

UCLA Study Reveals Novel Mechanism for Memory Formation During Sleep

UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep.

9 May 2024

New Technique Reveals Microscopic Heart Vessels with Unprecedented Clarity

New Technique Reveals Microscopic Heart Vessels with Unprecedented Clarity

A new imaging technique tested in patients could improve the evaluation of cardiac conditions and undiagnosed chest pain.

7 May 2024

Study Reveals Molecular Assembly of One of the Most Common Anti-Phage Systems

Study Reveals Molecular Assembly of One of the Most Common Anti-Phage Systems

One of the many secrets to bacteria's success is their ability to defend themselves from viruses, called phages, that infect bacteria and use their cellular machinery to make copies of themselves.

29 Apr 2024

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Alzheimer's disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year.

24 Apr 2024

Unlocking the Secrets of Lipid Droplet Proteins in Arabidopsis Thaliana Leaves

Unlocking the Secrets of Lipid Droplet Proteins in Arabidopsis Thaliana Leaves

Lipid droplets (LDs) serve as storage organelles found in plant leaves and seeds. While the functions of seed LD proteins in lipid metabolism are well understood, many leaf LD proteins remain unidentified.

24 Apr 2024

First Comprehensive Map of Protein Movement in Yeast Cell Cycle Revealed

First Comprehensive Map of Protein Movement in Yeast Cell Cycle Revealed

An international team led by researchers at the University of Toronto has mapped the movement of proteins encoded by the yeast genome throughout its cell cycle.

23 Apr 2024

Visualizing the Molecular Interaction of Formins with Actin Filaments

Visualizing the Molecular Interaction of Formins with Actin Filaments

Actin is a highly abundant protein that controls the shape and movement of all our cells. Actin achieves this by assembling into filaments, one actin molecule at a time.

17 Apr 2024

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