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Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

EBV-Targeting T-Cells Linked to Early MS Damage

The body's immune response to Epstein-Barr virus (EBV) may play a role in causing damage in people with multiple sclerosis, according to a new study led by UTHealth Houston.

12 Jan 2024

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

After stem cell transplantation, the donated immune cells sometimes attack the patients' bodies. This is known as graft versus host disease or GvHD.

9 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Scientists Develop Tiny Human Cerebellums to Decipher Disease and Design Therapies

In a first for USC Stem Cell scientists, the laboratory of Giorgia Quadrato, an assistant professor of stem cell biology and regenerative medicine, has pioneered a novel human brain organoid model that generates all the major cell types of the cerebellum, a hindbrain region predominantly made up of two cell types necessary for movement, cognition, and emotion: granule cells and Purkinje neurons.

5 Jan 2024

Genetic Twist in Tiny Protein Protects Against Parkinson's

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

3 Jan 2024

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.

3 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Mesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases.

27 Dec 2023

Study Reveals Tissue-Specific Effects of JAK1 Signaling in Inflammation

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues.

26 Dec 2023

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

Scientists at St. Jude Children's Research Hospital revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases.

26 Dec 2023

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

26 Dec 2023

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

21 Dec 2023

New Insights Into the Microbiome's Influence on Kidney Stone Risk

A new study from Lawson Health Research Institute and Western University published in the journal Microbiome has found changes in the microbiome in multiple locations in the body are linked to the formation of kidney stones.

21 Dec 2023

Light-Activated "Good Vibrations" can Destroy Cancer Cells

The Beach Boys' iconic hit single "Good Vibrations" takes on a whole new layer of meaning thanks to a recent discovery by Rice University scientists and collaborators, who have uncovered a way to destroy cancer cells by using the ability of some molecules to vibrate strongly when stimulated by light.

20 Dec 2023

Medical Condition News

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

EBV-Targeting T-Cells Linked to Early MS Damage

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Scientists Develop Tiny Human Cerebellums to Decipher Disease and Design Therapies

Genetic Twist in Tiny Protein Protects Against Parkinson's

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Hyperglycemia Impairs Mitochondrial Function and Survival of Human Adipose Tissue-Derived MSCs

Study Reveals Tissue-Specific Effects of JAK1 Signaling in Inflammation

Scientists Unravel the Mystery of Parkinson's Disease With 3D Protein Structures

The Adrenaline Puzzle Solved: Scientists Untangle Key Cell Receptor's Inner Workings

NEMO Protein Promotes Degradation of Harmful Alpha-Synuclein Aggregates in Parkinson's Disease

New Insights Into the Microbiome's Influence on Kidney Stone Risk

Light-Activated "Good Vibrations" can Destroy Cancer Cells

New Cell Model Paves Way for Faster Treatments for Neuromuscular Diseases

SERS Decodes Cancer's Whispers: Metabolites Reveal Tumor Communication and Potential Targets

Non-Invasive Early Cancer Detection Using Chromatin Signatures in Mononuclear Blood Cells

Epigenetic Changes in Insulin-Producing Cells Linked to Type 2 Diabetes Onset

Understudied Brain Cell Holds Key to Glioblastoma's Immunotherapy Resistance

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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