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Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Study Highlights Key Protein-Lipid Interactions in Mitochondrial Energy Production

By studying mutations in yeast and human cells, Johns Hopkins Medicine scientists say they have found that biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, play a crucial role in how our cells produce energy.

10 Jun 2024

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Scientists at the University of Dundee have uncovered the inner relay of a molecular switch that protects the brain against the development of Parkinson's disease.

10 Jun 2024

Study Unveils Broader Immune Response in EBV-MS Connection

Epstein-Barr virus (EBV) may have a greater effect on the development of multiple sclerosis (MS) than previously believed due to a higher level of cross-reactivity, which occurs when the immune system binds to the incorrect target.

10 Jun 2024

Critical NPC Protein Nup358 Linked to Myeloid Disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.

6 Jun 2024

Genetic Clues Unveil New Insights into Restless Leg Syndrome

Scientists have discovered genetic clues to the cause of restless leg syndrome, a condition common among older adults.

6 Jun 2024

How Tumor-Associated Fibrosis Shapes Immune Responses

Immunotherapy is based on harnessing a person's own immune system to attack cancer cells. However, patients with certain tumors do not respond to these therapies and it remains unclear why.

5 Jun 2024

Impact of Rare Disease Mutation Could Extend to More Prevalent Conditions

REX1 is a gene that is meant to direct the maintenance of the entire body’s DNA, but new research shows that when people are born with mutated TREX1, the DNA suffers catastrophic damage over time, resulting in a deadly rare disease known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL).

5 Jun 2024

Exploring Hepatic and Serum Proteomic Signatures in Werner Syndrome Mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 10, entitled, "Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse model."

4 Jun 2024

Immune Checkpoint Inhibitors Confer a Protective Effect on Bone by Promoting Osteogenesis

Immune checkpoint inhibitors (ICIs), widely employed anticancer agents, have been found to impact bone turnover, potentially conferring a protective effect on bone through the promotion of osteogenesis.

3 Jun 2024

Arrowhead's Plozasiran Reduces Triglyceride Rich Lipoproteins in Patients with Mixed Hyperlipidemia

Arrowhead Pharmaceuticals, Inc. today announced results from the Phase 2b double blind, randomized MUIR study of investigational plozasiran (formerly ARO-APOC3) in patients with mixed hyperlipidemia.

3 Jun 2024

Protein Imbalance Linked to Rare Developmental Disorder

According to a recent study from the University of Lausanne, serious intellectual impairments can result from both an excess or a shortage of a single protein.

31 May 2024

Newly Discovered CD8-fit Cells Could Revolutionize Cancer Treatment

A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.

30 May 2024

Unlocking the Power of Circadian Rhythms for Enhancing Cancer Immunotherapy

A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock – the biological pacemaker that governs daily rhythms in physiological processes, including immune functions – can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy.

29 May 2024

Researchers Develop Strategy to Replace Diseased Blood System Affected by Leukemia

Researchers have developed an approach to "deleting" a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells.

24 May 2024

How Immune Cells Decode Cancer's Turbocharged State

When cells become tumor cells, their metabolism changes fundamentally. Researchers at the University of Basel and the University Hospital Basel have now demonstrated that this change leaves traces that could provide targets for cancer immunotherapies.

22 May 2024