Molecular & Structural Biology

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New long-lived biological computers could potentially persist inside cells

Tiny biological computers made of DNA could revolutionize the way we diagnose and treat a slew of diseases, once the technology is fully fleshed out.

From National Institute of Standards and Technology (NIST) 24 Mar 2022

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

When something unexpected happens with DNA replication, cells call their own form of 911 to stop the process and rectify the problem.

23 Mar 2022

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism.

22 Mar 2022

Yale and uOttawa researchers partner to solve a puzzle rooted in the deepest past of evolution

For decades, scientists have been trying to unravel an enduring mystery of structural biology: Why do two otherwise identical protein forms found in everything from plants, amphibians and human beings hang onto a slight variation across the mighty span of evolution?

21 Mar 2022

Transcriptomic analysis of Alzheimer's patients reveals early organelle dysfunction in astrocytes

An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.

21 Mar 2022

Non-steroidal anti-inflammatory drugs help to enhance crop genome editing tools, study says

According to plant scientists at RIKEN, a class of non-steroidal anti-inflammatory drugs might be useful for studying the molecular processes underlying plant immunity.

21 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

Researchers develop an antibody as a tool for opening the blood-brain barrier

The brain is composed of billions of neurons-; vulnerable cells that require a protective environment to function properly.

17 Mar 2022

Researchers conduct a detailed study of skin layer, likely to assist in new products and treatments

Scientists have precisely studied the skin’s resistant barrier layer, producing the most thorough molecular map of its form to aid in the creation of novel skin products and treatments.

16 Mar 2022

Scientists use mRNA delivery to enhance muscle power

Mutations that cause muscle atrophy can be corrected using the CRISPR-Cas9 gene-editing tool.

16 Mar 2022

Researchers use GP2 and UMOD to prevent urinary tract infection

A team led by Karolinska Institute used AI and structural biology to learn more about two similar proteins that protect against bacterial infection in the urinary tract.

16 Mar 2022

Novel “green” synthesis of drug for inflammatory bowel disease

Steroids and antibody drugs are currently used to treat inflammatory bowel disease (IBD), which is characterized by chronic inflammation of the digestive tract.

16 Mar 2022

Scientists discover new details on vital enzyme that allows for DNA sequencing

Researchers released a study in Sciences Advances that disclosed new facts about a critical enzyme that allows DNA sequencing.

16 Mar 2022

Study highlights the role of genetic “bridge” in leukemia development

A complex network of three-dimensional structures assembles to read, copy and produce the genetic materials required for cellular function, for cells to thrive.

From Penn State University 14 Mar 2022

Researchers discover protein that turbocharges gene response

Researchers are attempting to figure out what happens when our genes are switched “on,” for many years.

From UC San Diego 14 Mar 2022

Cryo-EM reveals how a bacterial protein senses and rescues stalled ribosomes

As a molecular machine found in the cells of all organisms, the ribosome is responsible for making new proteins.

11 Mar 2022

New PRMC-MS method enables comprehensive analysis of membrane lipids

The development of new scientific ways to see more deeply into the building blocks of nature on a cellular level has led to the some of the greatest advances in medicine over the last century.

11 Mar 2022

Researchers identify the underlying molecular mechanism for development of chronic pain

One epigenetic factor as well as one organic anion transporter (OAT1), whose function in the nervous system was hitherto unknown, contribute to the development of chronic pain.

9 Mar 2022

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

8 Mar 2022

LMU researchers show how the brain distinguishes between various social influences

LMU researchers show what happens in the human brain when we try to influence other people or when we ourselves are influenced by others.

8 Mar 2022

Molecular & Structural Biology

New long-lived biological computers could potentially persist inside cells

Cryo-electron microscopes help determine how “911” molecule repairs DNA damage

Scientists reveal how 9-1-1 clamp attaches to DNA damage site for initiating effective repair

Yale and uOttawa researchers partner to solve a puzzle rooted in the deepest past of evolution

Transcriptomic analysis of Alzheimer's patients reveals early organelle dysfunction in astrocytes

Non-steroidal anti-inflammatory drugs help to enhance crop genome editing tools, study says

New database provides extensive information on kinase-associated neural protein phosphorylation

Researchers develop an antibody as a tool for opening the blood-brain barrier

Researchers conduct a detailed study of skin layer, likely to assist in new products and treatments

Scientists use mRNA delivery to enhance muscle power

Researchers use GP2 and UMOD to prevent urinary tract infection

Novel “green” synthesis of drug for inflammatory bowel disease

Scientists discover new details on vital enzyme that allows for DNA sequencing

Study highlights the role of genetic “bridge” in leukemia development

Researchers discover protein that turbocharges gene response

Cryo-EM reveals how a bacterial protein senses and rescues stalled ribosomes

New PRMC-MS method enables comprehensive analysis of membrane lipids

Researchers identify the underlying molecular mechanism for development of chronic pain

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

LMU researchers show how the brain distinguishes between various social influences

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