Molecular & Structural Biology

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Study elucidates genes responsible for Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

14 Dec 2020

Scientists aim to treat and prevent disease by understanding exercise benefits

A top exercise researcher and colleagues at the University of Virginia School of Medicine have launched an ambitious effort to understand the whole-body benefits of exercise so that doctors can use that information to prevent and treat disease.

11 Dec 2020

Newly identified Cas9 nucleases can improve genome editing

Scientists have explained two new compact Cas9 nucleases that will possibly extend the Cas9 toolbox for genome editing.

11 Dec 2020

A genetic shortcut to help visualize proteins at work

A group at Gladstone Institutes and UC San Francisco (UCSF) has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of protein complexes.

11 Dec 2020

Study shows how microplastics are internalized into living cells

Microplastics have polluted the global environment. These minute particles enter food chains, and end up in the digestive systems of humans and animals.

11 Dec 2020

Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Periodontal or gum disease recognized as significant risk factor for metabolic syndrome

Researchers from Tokyo Medical and Dental University (TMDU) identify a novel mechanism by which periodontal disease may cause diabetes

11 Dec 2020

Glyphosate could be used as biomarkers to predict incurring diseases in future generations

Exposure to the widely used weed-killer glyphosate makes genetic changes to rats that can be linked to increased disease in their grandchildren and great-grandchildren, a new study has found.

10 Dec 2020

Researchers develop a diagnostic tool for amyotrophic lateral sclerosis

Infrared analyses of neuronal proteins provide information on molecular changes in patients with ALS. This helps to verify their diagnosis.

10 Dec 2020

Appendiceal cancer among young patients harbors a distinct biology, shows study

The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease.

From Vanderbilt University 10 Dec 2020

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

Researchers identify way to disrupt the process that promotes pancreatic tumor growth

Researchers say they've identified a way to disrupt a process that promotes the growth of pancreatic cancers -- one of the most difficult and deadly cancers to treat.

9 Dec 2020

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system (*1) in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light.

9 Dec 2020

Researchers discover molecular mechanism of plant immune receptors

In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with MPIPZ researchers have succeeded for the first time in reconstructing the sequence of molecular events that activate an inactive plant immune receptor and thus mediate the death of the host cell.

8 Dec 2020

Researchers demonstrate strategy to control chemical reactions using antibodies

Antibodies are remarkable biomarkers: they are the cues that provide us with indications about many diseases and how our immune system counter them. Now a group of scientists from the University of Rome, Tor Vergata (Italy) has found a way to repurpose them so that they can trigger a specific chemical reaction.

8 Dec 2020

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

A study led by researchers at The University of Texas MD Anderson Cancer Center found that axi-cel, an autologous anti-CD19 chimeric antigen receptor (CAR) T cell therapy, is a safe and effective first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), a group with an urgent need for new and effective treatments.

8 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Molecular & Structural Biology

Study elucidates genes responsible for Glioblastoma invasiveness

Scientists aim to treat and prevent disease by understanding exercise benefits

Newly identified Cas9 nucleases can improve genome editing

A genetic shortcut to help visualize proteins at work

Study shows how microplastics are internalized into living cells

Study reveals new target to make breast cancer more sensitive to immunotherapy

Periodontal or gum disease recognized as significant risk factor for metabolic syndrome

Glyphosate could be used as biomarkers to predict incurring diseases in future generations

Researchers develop a diagnostic tool for amyotrophic lateral sclerosis

Appendiceal cancer among young patients harbors a distinct biology, shows study

Repair proteins can help healthy cells to avoid damage during cancer therapy

Researchers identify way to disrupt the process that promotes pancreatic tumor growth

Research clarifies regulatory impacts of ubiquitin-proteasome system on DNA damage repair

Researchers discover molecular mechanism of plant immune receptors

Researchers demonstrate strategy to control chemical reactions using antibodies

Study: CAR T cell therapy is a safe, effective therapy for high-risk large B-cell lymphoma

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Astrocytes modulate balance in neural networks, control decision making

Researchers identify genes that determine the shelf life of flaxseed oil

Gene therapy and medication can provide certain beneficial effects of physical exercise

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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