Proteomics

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Novel Method Tracks Phagosomal Protein Breakdown, Advancing Disease Research

Researchers at the FAMU-FSU College of Engineering have developed a novel method for investigating protein degradation in immune cells.

28 Mar 2025

Novel Bio-Conjugation Method Achieves High Efficiency and Stability for Protein Modification

A group of researchers from the Pohang University of Science and Technology Department of Materials Science and Engineering, under the direction of Professor Seung Soo Oh and Dr. Hyesung Jo, have created a novel method that allows for the accurate modification of particular proteins in intricate biological settings.

27 Mar 2025

Fusion Proteins Offer New Path for Antibody Generation in Disease Research

The Food and Drug Administration has approved more than 100 monoclonal antibodies to treat a range of diseases. Other antibodies are used by physicians to diagnose conditions or by scientists to advance research projects.

26 Mar 2025

Novel Tool Uses DNA Barcode System for Deep-Tissue RNA and Protein Imaging

For the Liu Lab, necessity is truly the mother of invention. The researchers were examining how the 3D organization of the genome controls development and needed to image hundreds of RNA molecules in a thick tissue sample to understand where and how genes were being expressed in cells.

13 Mar 2025

Unveiling the Shapeshifting Mechanisms of Metamorphic Proteins

The “shapeshifters” of bacterial, animal, and human cells are metamorphic proteins. Their capacity to rapidly transition between two distinct shapes allows them to perform a variety of tasks and adjust to shifting conditions.

11 Mar 2025

Circular RNA's Transformative Role in Tumor Biology and Treatment

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

10 Mar 2025

Low-Cost, Flexible Protein Detection Platform for Global Health

Chemical and biomolecular engineers at Georgia Tech have created a plug-and-play platform for the detection of disease protein biomarkers that is straightforward, adaptable, and user-friendly, eliminating the need for expensive laboratory equipment.

10 Mar 2025

Advanced Algorithm Predicts Structures of Disordered Proteins

The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging.

8 Mar 2025

Unveiling the Role of Flexibility in Designer Proteins

Artificially designed proteins typically rely on building blocks with strict symmetrical rules, allowing for computational prediction of their structures.

27 Feb 2025

Breakthrough mRNA Technology Paves the Way for Precision Medicine

Imagine a breakthrough in cancer treatment where only malignant cells are targeted, sparing healthy host cells; or patients with abnormal protein synthesis are treated to produce a healthy protein.

20 Feb 2025

Researchers Discover New Role of Mitofusin 2 in Cellular Health

Researchers from Cologne, Bochum, Padova and Angers have discovered a novel connection between mitochondrial function, protein quality control and cellular health, whose failure could be the leading cause in the currently incurable neurological disease Charcot-Marie-Tooth (CMT).

17 Feb 2025

PanK4 Protein Could Be Key to Better Control of Blood Sugar and Metabolism

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE). His team discovered that the protein PanK4 plays a crucial role in the energy metabolism of skeletal muscles.

13 Feb 2025

Exploring Chromatin's Resilience to Develop Anti-Aging Strategies

The process of aging in the body may be more resilient than previously believed, according to a new study.

4 Feb 2025

Durham University Researchers Unveil Tool to Predict Protein Metalation

Researchers at Durham University have achieved a major advancement in understanding how proteins bind metals inside cells, a process crucial to life.

30 Jan 2025

New Numbering System Advances Adhesion GPCR Research

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies.

29 Jan 2025

Fast and Precise Protein Labeling in Intact Tissues with MIT Technology

A new technology developed at MIT enables scientists to label proteins across millions of individual cells in fully intact 3D tissues with unprecedented speed, uniformity, and versatility.

27 Jan 2025

New Breakthrough Pushes DNA-Nanoparticle Motors Closer to Natural Protein Speed

DNA-nanoparticle motors are exactly as they sound: tiny artificial motors that use the structures of DNA and RNA to propel motion by enzymatic RNA degradation.

23 Jan 2025

AI-Powered Platform for Designing Novel Protein Interactions

Researchers at EPFL have opened up a world of possibilities in the computational design of molecular interactions for biomedicine by using deep learning to create new proteins that bind to complexes involving other small molecules, such as hormones or medications.

17 Jan 2025

Protein Shapes Reveal Deeper Evolutionary Relationships

According to a study published in the journal Nature Communications, the three-dimensional form of a protein can be utilized to determine long-standing evolutionary relationships in the tree of life.

16 Jan 2025

Researchers Discover How Protein Instability Drives Heritable Diseases

Most mutations which cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a massive study of human protein variants published today in the journal Nature.

10 Jan 2025