Proteomics

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Chaperone Proteins Unveil Their Role in Neurotransmission

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer's and Parkinson's along with many others, can occur.

19 Dec 2024

New Method Revolutionizes Protein Analysis for Diverse Populations

With a new method developed at the University of Bergen, researchers can now refine the analysis of proteins taking into account population diversity.

10 Dec 2024

Gradient Descent Approach to Optimizing AlphaFold2 Protein Predictions

Proteins are essential to human bodies as building blocks, transport systems, enzymes, and antibodies.

22 Nov 2024

Sylph: A Fast and Accurate Tool for Species-Level Metagenome Profiling

Sylph's innovative approach to metagenome profiling delivers high accuracy and efficiency, advancing research in microbial diversity and disease associations.

21 Nov 2024

Mouse Aging Proteomic Atlas Provides Insight into Age-Related Protein Shifts

With the worldwide population aging at an unprecedented rate, the prevention of age-related diseases has become a prominent issue.

18 Nov 2024

New Mechanism for Precise Protein Production Unveiled

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team.

15 Nov 2024

Domainex Integrates Nuclera’s eProtein Discovery System to Enhance Drug Discovery Services

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ system, and Domainex, a multi-award winning provider of integrated, pre-clinical drug discovery services, today announced that Domainex is the first contract research organization (CRO) to have installed the eProtein Discovery system and offer protein production services using the technology.

9 Nov 2024

MIT Engineers Develop Model to Decode Complex Biological Systems

Over the past two decades, new technologies have helped scientists generate a vast amount of biological data. Large-scale experiments in genomics, transcriptomics, proteomics, and cytometry can produce enormous quantities of data from a given cellular or multicellular system.

6 Nov 2024

Novel Approach to Isolating and Quantifying EV Cargo for Disease Diagnosis

Parkinson's disease (PD) and Alzheimer's disease (AD) are examples of brain illnesses that begin to develop in patients far earlier than the onset of their initial clinical symptoms.

4 Nov 2024

New Insights into Protein Transport in Plants and Nutrient Uptake

Botanists have come to understand the channels and transporters involved in the uptake and transport of nutrients, yet how are they positioned where they need to be?

30 Oct 2024

Key Regulator of Heart Repair

UCLA researchers identified the protein GPNMB as a key regulator in the heart’s healing process following a heart attack.

28 Oct 2024

New Study Links Cannabis Use to DNA Methylation Changes in Mental Health Pathways

Research reveals that frequent high-potency cannabis use alters DNA methylation, affecting mitochondrial and immune genes, with implications for mental health.

25 Oct 2024

Study Uncovers How MANF Protein Enhances Cellular Homeostasis and Longevity

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

21 Oct 2024

Recombinant Expression and Glycosylation of EBN Mucin

The first recombinant mucin protein obtained from the Edible-nest Swiftlet Aerodramus fuciphagus (AfMuc) has been successfully identified and synthesized by a research team.

21 Oct 2024

DeepUrfold: A New AI Model Uncovers Hidden Protein Relationships and Redefines Fold Space

This study introduces DeepUrfold, a deep learning model that uncovers subtle structural links between proteins, advancing the field of protein evolution.

21 Oct 2024

Study Unlocks Mechanisms Behind Nucleosome Arrays Using Signal Theory and Machine Learning

Findings show that machine learning can accurately predict nucleosome positions, emphasizing the relationship between nucleosome architecture and gene activity.

17 Oct 2024

Proteomics Analysis Reveals Aging-Related Changes in Bone

Bone mass declines with age, and the anabolic response to mechanical loading weakens. Although much research has focused on gene transcription, the mechanisms behind bone aging and the loss of mechanoresponsiveness at the protein level are still not well understood.

16 Oct 2024

Proteomics Reveals Age-Related Changes in Mouse Bone Formation

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 19 on October 12, 2024, entitled, "A proteomics approach to study mouse long bones: examining baseline differences and mechanical loading-induced bone formation in young-adult and old mice."

16 Oct 2024

Blood Vessel Cells Play a Crucial Role in Bone Development

Researchers have discovered a protein that inhibits the activity of bone-forming cells (osteoblasts) by preventing their maturation during the process of migrating to bone-formation sites.

14 Oct 2024

Researchers Develop Fluorescent Biosensor to Study PKC Activity

Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival.

14 Oct 2024