Proteomics

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New Approaches to Treating Circadian Rhythm Disorders

Researchers from the University of California and Duke-NUS Medical School have figured out how to control the human body's internal clock. It was discovered that this regulator is located exactly at the end of Casein Kinase 1 delta (CK1δ), a protein that sets the pace for circadian rhythm, or internal biological clock, which regulates sleep-wake cycles and other daily activities.

7 Oct 2024

Genes2Genes Unlocks New Potential for Detecting Gene Expression Changes

Genes2Genes an accurately infer alignments in simulated and real datasets of single-cell trajectories and capture sequential mismatches and matches in individual genes.

4 Oct 2024

New Insights into U1 Snrnp Functions in Plant Splicing Mechanisms Using Arabidopsis

U1 snRNP interactions in Arabidopsis highlight its dual role in splicing and mRNA regulation, essential for maintaining transcript integrity and growth.

2 Oct 2024

New AI Model ProteinGenerator Revolutionizes Protein Design with Sequence and Structure Integration

Harnessing deep learning, ProteinGenerator designs diverse proteins with specific properties, offering new avenues for drug development and biotechnology.

2 Oct 2024

Study Reveals Simplified Rules for Predicting Protein Behavior

In a study published today in the journal Nature, researchers from the Centre for Genomic Regulation (CRG) and the Wellcome Sanger Institute have discovered that mutations affect protein stability following remarkably simple rules.

26 Sep 2024

blotRig Tool Transforms Western Blot Design and Statistical Analysis for Reproducibility

Improving reproducibility in Western blot experiments through rigorous design and advanced statistical analysis is crucial for accurate protein quantification.

26 Sep 2024

New Method Analyzes Tooth Enamel Proteins to Gain Insights into Human Health History

A new way of looking at tooth enamel could give scientists a path to deeper understanding of the health of human populations, from the ancient to the modern.

20 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Automated DNA Separation for Sexual Assault Cases: A Breakthrough in On-Site Forensic Analysis

This study presents a digital microfluidics approach for rapid DNA extraction from sexual assault samples, significantly improving forensic analysis efficiency.

11 Sep 2024

Rice Researchers Map Protein Interactions for Creating Functional Gas Vesicles

As far as water gear goes, floaties are not exactly high tech. But the tiny air-filled bubbles some microorganisms use as flotation devices when they compete for light on the water surface are a different story.

4 Sep 2024

Insights into Peptide Clumping Could Transform Drug Design and Material Science

Scientists from China have investigated how short peptide chains aggregate together in order to deepen our understanding of the process, which is crucial for drug stability and material development.

4 Sep 2024

Study Reveals Cytoskeleton as Key Component in Aging Dermal Fibroblasts

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 16 on August 27, 2024, entitled, "Proteomic and secretomic comparison of young and aged dermal fibroblasts highlights cytoskeleton as a key component during aging."

4 Sep 2024

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Researchers at Kanazawa University report in eLife on deciphering the actin structure-dependent preferential cooperative binding of cofilin.

29 Aug 2024

Study Reveals Dual Role of Skin Proteins in Strength and Cell Signaling

An extensive family of proteins that gives human skin mechanical strength also appears to organize molecular signals that control skin cell activity, a study led by UT Southwestern Medical Center researchers shows.

22 Aug 2024

New AI Tool Predicts Protein Behavior in Cellular Context

A fish on land can still wave its fins, but the outcomes are very different when the creature is in water. The comparison, attributed to prominent computer scientist Alan Kay, is used to demonstrate the importance of context in clarifying research issues.

19 Aug 2024

Harnessing Proteomics to Explore the Role of Probiotic Bacteria in Human Health

The currently available proteomics strategies can be used to identify and quantify probiotic bacterial proteins.

19 Aug 2024

Advancing Cardiovascular Drug Discovery: Translational Framework Leverages Genetic and Proteomic Insights

A validated framework to translate these recent advances in genoproteomics into clinical applications in cardiovascular drug development.

19 Aug 2024

Study Uncovers Biomarkers for Low Muscle Mass, Offering Insights for Personalized Prevention

Machine learning models to analyze computed tomography (CT) images of the chest and a proteomics approach to determine blood protein biomarkers.

15 Aug 2024

Novel Technique to Study Ubiquitination

Once human proteins are synthesized, they go through some chemical changes. These adjustments control their stability, functionality, and structure.

13 Aug 2024

New AI Model Predicts Protein-DNA Binding Specificity with High Accuracy

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

12 Aug 2024

Proteomics

New Approaches to Treating Circadian Rhythm Disorders

Genes2Genes Unlocks New Potential for Detecting Gene Expression Changes

New Insights into U1 Snrnp Functions in Plant Splicing Mechanisms Using Arabidopsis

New AI Model ProteinGenerator Revolutionizes Protein Design with Sequence and Structure Integration

Study Reveals Simplified Rules for Predicting Protein Behavior

blotRig Tool Transforms Western Blot Design and Statistical Analysis for Reproducibility

New Method Analyzes Tooth Enamel Proteins to Gain Insights into Human Health History

One-Third of Antibody Drugs Show Unintended Target Binding

Automated DNA Separation for Sexual Assault Cases: A Breakthrough in On-Site Forensic Analysis

Rice Researchers Map Protein Interactions for Creating Functional Gas Vesicles

Insights into Peptide Clumping Could Transform Drug Design and Material Science

Study Reveals Cytoskeleton as Key Component in Aging Dermal Fibroblasts

High-Speed Atomic Force Microscopy Reveals Cofilin Binding Patterns in Actin Filaments

Study Reveals Dual Role of Skin Proteins in Strength and Cell Signaling

New AI Tool Predicts Protein Behavior in Cellular Context

Harnessing Proteomics to Explore the Role of Probiotic Bacteria in Human Health

Advancing Cardiovascular Drug Discovery: Translational Framework Leverages Genetic and Proteomic Insights

Study Uncovers Biomarkers for Low Muscle Mass, Offering Insights for Personalized Prevention

Novel Technique to Study Ubiquitination

New AI Model Predicts Protein-DNA Binding Specificity with High Accuracy

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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