Proteomics, Metabolomics and Lipidomics News and Research

Latest Proteomics, Metabolomics and Lipidomics News and Research

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

It has been found by researchers that phosphorylated α-synuclein, a protein linked to a number of neurodegenerative illnesses, including Parkinson's disease and Lewy body dementia, is also engaged in the regular processes of neuronal communication in a healthy brain.

10 Jan 2024

Bacterial "Freight Elevator" Transports Camouflage Molecule for Immune Evasion

Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane.

9 Jan 2024

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

After stem cell transplantation, the donated immune cells sometimes attack the patients' bodies. This is known as graft versus host disease or GvHD.

9 Jan 2024

Bacterial “Barcode” Deciphers the Fate of Proteins, Impacting Pathogen Behavior

Researchers at McMaster University have found a molecular “barcode” system that pathogenic bacteria use to identify harmful from beneficial molecules.

9 Jan 2024

Computational Creation of Complex Protein All-α Structures

Based on their amino acid sequences, proteins fold into distinct three-dimensional structures that determine their function. While de novo protein design has advanced significantly, complex all-αproteins, in which α-helices are not stacked in a parallel fashion within three-dimensional structures, have not been as easily designed.

8 Jan 2024

Largest Gestational Diabetes Study Reveals 9 New Genetic Regions

The largest genetic study of gestational diabetes to date has led to a discovery of nine novel genetic regions linked to this severe and common pregnancy complication.

8 Jan 2024

Engineering Plants to Fight Disease with Friendly Bacteria

For the first time, scientists have modified the plant microbiome to increase the amount of “good” bacteria that shield the plant from harm.

8 Jan 2024

Unlocking the Gut's Metabolic Secrets

The variety of enzymes that microbes employ to make energy in the low-oxygen environment of the gut is highlighted by a survey of bacterial genomes.

8 Jan 2024

Novel Peptides from South American Bushmaster and Pit Viper

The venom of the South American bushmaster, a resident of tropical rainforests, and the pit viper Cotiara, which lives in southern Brazil, both contain fragments of hemorrhagic toxins that may be used to treat high blood pressure.

8 Jan 2024

New Method Reveals Bacteria's Protein Targeting System

Disease-causing bacteria of the genus Salmonella or Yersinia can use tiny injection apparatuses to inject harmful proteins into host cells, much to the discomfort of the infected person.

5 Jan 2024

B12-Producing Gut Bacteria Modulate Neurotransmitter Levels and Reduce Seizures in C. elegans

A new study published in Nature Cell Biology by Mark Alkema, PhD, professor of neurobiology, establishes an important molecular link between specific B12-producing bacteria in the gut of the roundworm C. elegans and the production of acetylcholine, a neurotransmitter important to memory and cognitive function.

5 Jan 2024

Mechanism of Pathogenic Fungus Aspergillus fumigatus Unveiled

An international team of researchers, led by Professor Gustavo Goldman of the University of São Paulo and Maynooth University's Dr Özgür Bayram, has unveiled ground-breaking findings on Aspergillus fumigatus, which can cause deadly disease in humans.

5 Jan 2024

Research Reveals Unforeseen Functions for Autophagy Genes in Neuronal Health and Aging

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions

5 Jan 2024

A Pair of Force-Activated Gene Regulating Proteins Guide Fetal Bone Development

A pair of proteins, YAP and TAZ, has been identified as conductors of bone development in the womb and could provide insight into genetic diseases such as osteogenesis imperfecta, known commonly as "brittle bone disease."

5 Jan 2024

New Method Designs Proteins With Complex Shapes

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin.

5 Jan 2024

Elucidating the Adaptive Genetic Mechanisms of Chiridota heheva in Hydrothermal Environments

Animals are unlikely to thrive in hydrothermal vents because of their harsh chemistry, which includes an acidic pH and a high concentration of methane and sulfur.

4 Jan 2024

Unraveling the Mysteries of COPII-Mediated Protein Transport

Similar to postal workers who deliver packages in inclement weather, such as snow, rain, or heat waves, a vital set of proteins found in mammals enables cells to operate normally, even in less-than-ideal circumstances.

4 Jan 2024

Zipping Up Chromosomes: The Synaptonemal Complex Revealed

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

4 Jan 2024

Improved Mapping of Small-Molecule Binding Sites in Cells

Researchers at Scripps Research created a novel, high-resolution method for identifying putative treatment targets on proteins in living cells.

3 Jan 2024

Genetic Twist in Tiny Protein Protects Against Parkinson's

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

3 Jan 2024