Neurodegenerative Diseases News and Research

RSS

Experimental model reveals the protective role of antioxidants in neurodegenerative disorders

Researchers used a model to replicate the blood-brain barrier and successfully demonstrated how antibody guards the brain against inflammation.

2 Jul 2021

Genetic treatment may provide a new approach to addressing obsessive-compulsive disorder (OCD)

For the first time, scientists have linked distinct patterns of genetic mutations with OCD in humans using genome-wide analysis.

29 Jun 2021

Specific chemical feature of a key protein may lead to neurodegenerative diseases

Scientists have found that a particular chemical feature of a crucial protein may cause it to build up in the brain and lead to various disorders.

28 Jun 2021

Novel protein interactions aid in the recovery process of brain damage

Patients suffering from brain damage largely depend on rehabilitation therapy for recovery, because no other effective treatment options are available.

21 Jun 2021

New types of glial cells in the brain may treat neurodegenerative diseases

Researchers from the University of Basel have discovered two types of glial cells that may play an important role in brain plasticity and repair.

15 Jun 2021

Study reveals key molecule involved in myelin repair

New research works indicate that new brain cells are continuously formed in response to physical exercise, injury, and mental stimulation.

9 Jun 2021

Single biomarker in the blood can accurately indicate underlying neurodegeneration

Levels of a protein called neurofilament light chain (NfL) in the blood can identify those who might have neurodegenerative diseases such as Down's syndrome dementia, motor neuron disease (ALS) and frontotemporal dementia, when clinical symptoms are not definitive.

8 Jun 2021

Newly identified protein helps tumors evade the immune system

Researchers at the Francis Crick Institute have identified a protein that helps tumors evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival. The protein could become a target for future cancer treatments.

3 Jun 2021

Researchers prove that drugs designed for bacteria have the potential to act on human cells

Antibiotics used to treat common bacterial infections may potentially be used to treat human illnesses such as cancer, at least theoretically.

27 May 2021

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases.

25 May 2021

Exposure to even low levels of lead can trigger epigenetic changes

A research team from Brazil and Portugal has identified a link between a microRNA (miRNA) and the presence of lead in an organism.

18 May 2021

Cells within the center of a tumor have the highest chance of spreading around the body

Researchers from the Francis Crick Institute, Royal Marsden, UCL and Cruces University Hospital have found that cells from different parts of kidney tumors behave differently, and surprisingly, cells within the center of a tumor are the most aggressive and have the highest chance of spreading around the body.

18 May 2021

New drug-like compound designed to stop malaria in its tracks

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

13 May 2021

Shortage of DNA building blocks triggers inflammation

Mitochondria are the energy suppliers of our body cells. These tiny cell components have their own genetic material, which triggers an inflammatory response when released into the interior of the cell.

3 May 2021

Study identifies single protein key to regulating sex differences in Parkinson’s disease

Neuroscientists have found that a single protein is critical to controlling sex disparities in the brain’s susceptibility to age-related neuron loss.

From University of Pittsburgh 29 Apr 2021

Natural molecule can effectively block the binding of human antibodies to SARS-CoV-2

Researchers have found that a natural molecule can effectively block the binding of a subset of human antibodies to SARS-CoV-2. The discovery may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.

23 Apr 2021

Chaperone protein imbalance initiates toxic accumulation of tau in the aging brain

Chaperone protein imbalance can play a significant role in initiating toxic accumulation of tau in the aging brain - an early step in the development of Alzheimer's disease and related neurodegenerative disorders known as tauopathies, a new preclinical study by University of South Florida Health (USF Health) neuroscientists suggests.

21 Apr 2021

Study shows how tau aggregates promote Alzheimer’s disease

If looked deep into the brain of a patient with Alzheimer’s disease or those suffering from the most types of dementia or the concussion-associated syndrome, called chronic traumatic encephalopathy (CTE), there would be hairball-like tangles of a protein known as tau—a common suspected culprit.

20 Apr 2021

Inhibiting a specific protein could increase tumor sensitivity to PARP inhibitors

Researchers at the Francis Crick Institute have found that blocking a specific protein could increase tumor sensitivity to treatment with PARP inhibitors. Their work published in Science , suggests combining treatments could lead to improved therapy for patients with inheritable breast cancers.

9 Apr 2021

Experimental antibody therapies for neurodegenerative diseases may lead to brain inflammation

A research team has made a novel finding that indicates that experimental antibody treatments for Alzheimer’s disease have an accidental adverse impact.

31 Mar 2021