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A “stress test” with a previously unknown gene to revive the exhausted T cells

The task of battling cancer cells can fatigue T cells employed in immunotherapy treatments, or they could shut down once they penetrate tumors. Researchers at the Gladstone Institutes and UC San Francisco have strengthened the therapeutic cells’ resistance via a CRISPR-based edit on their genomes.

30 Aug 2022

Chromatin displays different dynamics in cells during organ-formation

Recent research from the School of Medicine has illuminated the development of the liver, lungs, and digestive system. This result may have significant ramifications for the comprehension of cancer.

30 Aug 2022

Therapeutic mRNAs do not significantly impact translational fidelity

Synthetic mRNA therapeutics for the treatment and prevention of disease has attracted a lot of interest due to the exceptional efficacy of mRNA vaccinations against SARS-CoV-2.

30 Aug 2022

New CRISPR RNA-guided Caspases could lead to promising antiviral and tissue engineering tools

New research from Cornell offers insights into a line of CRISPR systems, which could lead to promising antiviral and tissue engineering tools in animal and plants.

26 Aug 2022

The correlation between high facial similarity and shared DNA

DNA analysis and a collection of photographs of genetically unrelated lookalikes have shown that strong facial likeness is tied to shared genetic variations. The article is published in Cell Reports on August 23rd, 2022.

25 Aug 2022

Unconventional T cells migrate and influence immune responses

There are 600 to 800 lymph nodes in the human body, which are specialized organs that cause immunological reactions. Lymph nodes are connected to the various organs by lymph vessels, allowing them to receive information about infections in the body.

25 Aug 2022

The complex link between pancreatic malformations and the “dark genome”

For the first time, scientists at the Centre for Genomic Regulation (CRG) have discovered a DNA sequence that is essential for pancreatic development and function.

25 Aug 2022

Brain cells with the same birthdate display distinct connectivity

According to a recent study, brain cells with the same “birthdate” are more likely to connect into cooperative signaling circuits that perform a variety of tasks, including memory storage.

From New York University (NYU) 25 Aug 2022

Diseased connective tissue cells alter the physical structure of their genomes

Researchers at Penn Medicine have found that when cells are impacted by the disease, the physical structure of their genome changes.

25 Aug 2022

Scientists discover latent stem cells that respond to injury in the central nervous system of mice

Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice. If a similar type of cell exists in humans, they could offer a new therapeutic approach to treat brain and spinal cord injuries.

23 Aug 2022

Novel method maps all gene expression patterns to a single reference embryo

Years of work by Trinity College Dublin developmental biologists in collaboration with colleagues at the University of Edinburgh’s MRC Human Genetics Unit has resulted in an unparalleled resource that will help researchers assess how key genes control the differentiation of tissues and organs in developing embryos.

23 Aug 2022

Study explains the dynamics underlying liver damage

The immune system may attack the liver when fat builds up there. The chemical that triggers these responses has been discovered by Weill Cornell Medicine researchers in a recent study, and this information helps to explain the dynamics of liver damage that can accompany type 2 diabetes and obesity.

23 Aug 2022

Researchers create a gas that helps to develop and trigger plant immunity

The flash of lightning and the movement of the aurora contain the plasma, the fourth state of matter that scientists have exploited to create a gas that may trigger plant immunity against widespread illnesses.

23 Aug 2022

Climate change may contribute to increased wheat price spikes and larger economic inequality

Wheat is a key source of nutrition for people across the globe, providing 20% of calories and protein for 3.4 billion people worldwide.

22 Aug 2022

Defense mechanisms of horticulture crops against fungal infections

Recent research on defense responses of horticulture crops to fungal infections, novel ways to govern the induction of plant resistance, issues, challenges, and future research objectives have been summarized by scientists from the Chinese Academy of Sciences.

22 Aug 2022

Researchers discover a genome that provides an understanding of diterpenoids

Salvia officinalis (S. officinalis), known as sage or common sage, and the Chinese sage (S. miltiorrhiza), or Danshen (red sage) in Chines, pertain to the Lamiaceae family and have been grown for medicinal purposes for a long time in Europe and East Asia, respectively.

22 Aug 2022