Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New breakthrough in AI system could significantly accelerate biological research

In a major scientific advance, the latest version of DeepMind's AI system AlphaFold has been recognized as a solution to the 50-year-old grand challenge of protein structure prediction, often referred to as the 'protein folding problem', according to a rigorous independent assessment.

1 Dec 2020

Study shows how drug-like small molecules regulate the activity of ion channels

Researchers have recently discovered how the function of therapeutically relevant ion channels is regulated by drug-like small molecules.

24 Nov 2020

Researchers look for mechanisms that stabilize or destabilize key sections of biomolecules

Knowing precisely where proteins are frustrated could go a long way toward making better drugs. That's one result of a new study by Rice University scientists looking for the mechanisms that stabilize or destabilize key sections of biomolecules.

24 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Interpretable machine learning models create new options for drug discovery

Machine learning has been extensively utilized in the chemical sciences for a wide range of processes, including drug design.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

Research projects receive BTCA awards to develop new drugs

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

From Harvard Medical School 30 Oct 2020

Researchers receive $2.6 million grant to examine tau-glycan interactions involved in Alzheimer's disease

Tangles of misfolded tau proteins in the brain are closely associated with memory loss in patients with Alzheimer's disease.

29 Oct 2020

Novel machine learning algorithm helps identify binding sites in drug targets

Scientists from the iMolecule group at Skoltech Center for Computational and Data-Intensive Science and Engineering (CDISE) developed BiteNet, a machine learning (ML) algorithm that helps find drug binding sites, i.e. potential drug targets, in proteins.

27 Oct 2020

New collaboration to develop machine learning methods for chemical discovery

The discovery and formulation of new drugs, antivirals, antibiotics and in general chemicals with tailored properties is a long and painstaking process.

21 Oct 2020

Ziath to exhibit sample management products at virtual biobanking symposia

Ziath announce their participation in two key virtual symposia for scientists involved in biobanking - the ISBER Virtual Symposium 2020 and the Europe Biobank Week 2020.

From Ziath Ltd 16 Oct 2020

Innovative machine learning concepts can help develop new drugs

Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields.

15 Oct 2020

Researchers identify a new method to synthesize miniaturized antibodies

Scientists have identified a new method to synthesize miniaturized antibodies, paving the way for a promising new class of therapies for various diseases.

From University of Bath 30 Sep 2020

New precision drug targeting cancer's ability to repair DNA shows promise

A new precision drug which stops cancer from repairing its DNA has shown promise in an early-stage clinical trial - highlighting the potential of a new class of drugs known as ATR inhibitors.

29 Sep 2020

Scientists Kill Cancer Cells By 'Shutting The Door' To The Nucleus

Scientists have shown that blocking the construction of nuclear pores complexes shrank aggressive tumors in mice while leaving healthy cells unharmed.

29 Sep 2020

Scientists use cryo-EM method to extract molecular data

Scientists have made enormous strides in the field of structural biology, looking into the activities of nature at the smallest scale.

24 Sep 2020

How do hallucinogenic drugs exert their actions on the brain?

Not much is known about the fundamental mechanisms in the brain of hallucinogenic drugs and the way they induce their hallucinogenic effects.

21 Sep 2020

CRISPR in a Box: New educational gene editing tool kit

Introducing CRISPR in a Box™ - it's not a new crunchy cereal or the latest snack - it's an educational tool kit consisting of state-of-the-science gene editing technology that could be coming to a school near you.

10 Sep 2020