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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Researchers introduce CRISPR to enable gene editing in cockroaches

According to a study released by Cell Press on May 16th, 2022, in the journal Cell Reports Methods, scientists have created a CRISPR-Cas9 technique to facilitate gene editing in cockroaches.

23 May 2022

New supramolecular CRISPR–Cas9 carrier supports much effective genome editing

Clustered regularly interspaced short palindromic repeats (CRISPR) and their accompanying protein, CRISPR-associated protein 9 (Cas9), several years ago, made international news as a game-changing genome editing system.

18 May 2022

bit.bio launches Huntington’s disease human cell model

First neurodegenerative disease model launched from bit.bio's new ioDisease Model portfolio.

From bit.bio 10 May 2022

Two new genomic studies provide insight into evolutionarily unique traits of cephalopods

Squid, octopus, and cuttlefish – even to scientists who study them – are wonderfully weird creatures. Known as the soft-bodied or coleoid cephalopods, they have the largest nervous system of any invertebrate, complex behaviors such as instantaneous camouflage, arms studded with dexterous suckers, and other evolutionarily unique traits.

5 May 2022

Researchers propose a new fusion method in gene editing to reduce DNA sizes

Researchers who are working on CRISPR/Cas9-mediated gene-editing technology have developed a technique to boost editing performance by reducing DNA deletion sizes.

3 May 2022

Researchers analyze the significance of two-pore channels in plant cells

TPCs (two-pore channels) are old ion channels found in both animal and plant cells. These ion channels serve key roles in biological activity in numerous tissues in animals, including humans, like the brain and nervous system.

From Tokyo University of Science 3 May 2022

Rutgers researcher will use genomics, cell biology to pinpoint genes involved in coral bleaching

A Rutgers researcher will use genomics, genetics, and cell biology to identify and understand the corals' response to heat stress conditions and to pinpoint master regulatory genes involved in coral bleaching due to global warming and climate change.

From Rutgers University 29 Apr 2022

Study identifies novel targets for treating sorafenib-resistant hepatocellular carcinoma

Research headed by Professor Xiujun Cai used the CRISPR/cas9 system to screen the entire genome of hepatocellular carcinoma cells (HepG2) under sorafenib treatment.

25 Apr 2022

National DNA Day 2022: an interview with Professor Matthew Cobb

To celebrate National DNA Day 2022, we spoke to science communicator Professor Matthew Cobb.

From The University of Manchester 25 Apr 2022

Study highlights an effective technique to overcome the rice yield constraint

Tradeoffs between diverse agronomic traits constrain crop breeding to a great extent. Because gene pleiotropy causes many of these tradeoffs, lowering gene pleiotropy may make it simpler to overcome tradeoffs in plant breeding.

22 Apr 2022

Study identifies new targets for treating sorafenib-resistant hepatocellular carcinoma using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Researchers use CRISPR gene editing tool to analyze globin gene switching

CRISPR gene editing—a form of “molecular scissors”—was used by UNSW researchers to investigate how deletions in one section of the genome might impact the expression of surrounding genes.

From The University of New South Wales (UNSW) 19 Apr 2022

A new breakthrough in the quest to improve photosynthesis in certain crops

A Cornell University study describes a breakthrough in the quest to improve photosynthesis in certain crops, a step toward adapting plants to rapid climate changes and increasing yields to feed a projected 9 billion people by 2050.

19 Apr 2022

Powerhouse-pruning protein may be a sound target to help trigger new blood vessel growth

A protein that helps keep our cell powerhouses working at a premium appears to also help make energy rapidly available when it's time to make new blood vessels.

5 Apr 2022

Researchers employ CRISPR gene-editing technology in human blood to cure HIV

Northwestern Medicine researchers are employing recent developments in CRISPR gene-editing technology to discover novel biological method that could lead to longer-lasting treatments and new therapeutic tactics for the Human Immunodeficiency Virus (HIV).

5 Apr 2022

Evonetix granted patent for technology enabling thermally-controlled DNA synthesis

EVONETIX LTD (‘Evonetix’), the synthetic biology company bringing semiconductor technology to DNA synthesis, today announced it has been granted patent EP3551331B1 in Europe for its proprietary thermal control technology for DNA synthesis, as well as the design and manufacture of its silicon chips.

From Evonetix 4 Apr 2022

Researchers determine major protein complexes that cause ribosome production

Scientists at UT Southwestern have discovered a four-protein complex that seems to play a significant function in the formation of ribosomes, which serve as protein factories for cells, as well as a surprise role in neurodevelopmental diseases.

1 Apr 2022

Study shows how CRISPR RNAs help the immune system to identify and combat viruses

What tasks must be completed today, and which are the most vital? In their daily lives, people must continuously make priorities. Bacteria are no exception: while using CRISPR to battle viruses, they must prioritize as well. However, the method by which this priority is accomplished is unknown.

23 Mar 2022

Research highlights how genome editing tool CRISPR knocks off genes in cancer cells

Researchers have created a novel method that allows them to correlate particular genes to complex tumor properties at a size and resolution that has never been achievable.

21 Mar 2022

A fresh perspective on genome-editing tools, likely to help microbial communities

Microbial communities in nature are made up of a variety of bacterium species. This makes it challenging to isolate and culture individual bacterium species in the laboratory. New tools have been created by researchers to assist.