Drug Discovery News and Research

RSS

The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

New breakthrough could accelerate drug development

Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development.

From Newcastle University 11 May 2020

Project Expands Use Of Metal Catalysts For Drug Discovery

The use of metals in drug delivery could offer major benefits, including allowing for lower dosages of a medication to achieve therapeutic effects.

7 May 2020

AI accelerates drug discovery to fight COVID-19

A global race is underway to discover a vaccine, drug, or combination of treatments that can disrupt the SARS-CoV-2 virus, which causes the COVID-19 disease, and prevent widespread deaths.

24 Apr 2020

Scientists elucidate precise shape of a key player in human metabolism

A USC-led international team of scientists has found the precise shape of a key player in human metabolism, which could lead the way to better treatments for obesity and other metabolic disease.

24 Apr 2020

New database of 14,000 known macrolactones could aid future drug discovery

Researchers from North Carolina State University and Collaborations Pharmaceuticals have created a free-to-use database of 14,000 known macrolactones - large molecules used in drug development - which contains information about the molecular characteristics, chemical diversity and biological activities of this structural class.

22 Apr 2020

Experience Matters For Immune Cells

The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer.

17 Apr 2020

Identifying Potential Drugs Earlier In Discovery

Scientists have developed a technique that could significantly reduce the time of discovering potential new antibody-based drugs to treat disease.

16 Apr 2020

Protein Abundant In The Heart Plays Key Role In Blood Clotting

Heart protein cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot.

3 Apr 2020

Researchers develop 3D cultured cells that mimic liver fibrosis

Headed by researchers from Japan-based Tokyo University of Agriculture and Technology (TUAT), a group of scientists has effectively established three-dimensional (3D) cultured tissue that imitates liver fibrosis, which is a major trait of non-alcoholic steatohepatitis (NASH).

2 Apr 2020

New method for mapping the structures of heparan sulfate sugars

Heparin, the blood-thinning drug, is used worldwide. However, to date, mapping of the fundamental sugar structures of heparin and the wider class of heparan sulfate sugars in cells has not been accomplished.

23 Mar 2020

Study offers detailed molecular map of interaction patterns of GPCR and different G protein subtypes

G protein-coupled receptors (GPCRs) have crucial roles to play in cell signal transduction and can be used as vital therapeutic targets for several diseases.

20 Mar 2020

Bacteria’s ability to develop novel peptides for cancer treatment

At Texas A&M University, chemists have identified a new way to beat viruses at their own game—take a p[h]age from bacteria’s playbook and, in the process, develop new kinds of drugs to combat cancer and a range of other human diseases.

20 Mar 2020

IL-2's flexible structure helping the immune system

Scientists have known that interleukin-2 (IL-2), a signaling molecule, strongly influences the immune system. However, attempts to leverage its potential for therapeutic purposes have went futile due to serious side effects.

From University of California Santa Cruz 18 Mar 2020

New discovery reveals earliest known instance of complex form of protein regulation

Researchers have given a new life to the ancient history of two proteins, thus gaining insights into the origin of an age-old molecular partnership.

9 Mar 2020

Quick & easy extraction of biological & aqueous samples

Porvair Sciences has introduced Microlute SLE 96-well plates and cartridges to enable you to quickly and easily extract a wide range of acidic, basic and neutral analytes from samples with greater reproducibility.

3 Mar 2020