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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Experts grow novel cell lines in a chemically defined medium

Researchers for the first time acquired stem cells from livestock that was grown under chemically defined conditions.

13 Dec 2021

Powering the Biotechnology Revolution through Cloud R&D

In this interview, we speak to Sajith Wickramasekara, CEO and Co-Founder of Benchling, about cloud R&D and how it is powering the biotechnology revolution.

From Benchling 10 Dec 2021

Researchers come up with a novel technique to produce single-sex litters

Researchers from the Francis Crick Institute along with the University of Kent utilized gene-editing technology to produce male-only and female-only mice litter with 100% efficacy.

7 Dec 2021

Announcing the Winners of The Scientist’s Top 10 Innovations of 2021

Each year The Scientist seeks to highlight the latest and greatest tools, technologies, and techniques to hit the life science landscape.

From Resolve Biosciences 6 Dec 2021

Researchers identify a new approach to triggering differentiation in acute myeloid leukemia

In the late 1980s, scientists developed a revolutionary approach to treating acute myeloid leukemia (AML), a type of blood cancer. Called differentiation therapy, it amounted to a bona fide cure for many patients.

2 Dec 2021

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Study identifies genes that protect ovarian cancer from antitumor immunity

Immunotherapies are exhibiting better clinical benefit in the treatment of numerous cancers, particularly when used along with chemotherapy.

2 Dec 2021

Novel technique precisely corrects DNA errors in cultured patient cells

Scientists recently created a technique to accurately and quickly correct genetic alterations in the cultivated patient cells.

2 Dec 2021

New CRISPR technology could improve diagnostic tests for COVID-19

A new type of CRISPR platform that leverages the benefits of a compact RNA-editing protein could result in enhanced diagnostic tests for COVID-19.

2 Dec 2021

Researchers identify new route to produce complex antibiotics

Researchers recently discovered a novel route to produce complex antibiotics taking advantage of gene editing to re-program pathways to future medicines.

From The University of Manchester 2 Dec 2021

Using CRISPR/Cas9-based gene editing to produce the ‘perfect’ barley

After a spell of unexpected rain, before the harvest season, a farmer may be faced with the unpredictable problem of untimely sprouting of barley.

26 Nov 2021

New links found between CRISPR, p53 and other cancer genes that could prevent accumulation of mutated cells

A protein that protects cells from DNA damage, p53, is activated during gene editing using the CRISPR technique.

18 Nov 2021

Researchers perform targeted mutagenesis to prolong dormancy in barley

Unexpected rain before the harvest season leaves the farmer with a problem—untimely sprouting of barley.

17 Nov 2021

CRISPR introduces potentially dangerous changes in cells, reveals research

New research revealed that gene editing, particularly gene knockout, with CRISPR-Cas9 can support cells with mutated gene forms associated with cancer.

15 Nov 2021

New epigenetic editing technique could help treat a wide range of diseases

All the cells found in the body of an individual have the same genetic code.

15 Nov 2021

CRISPR screening identifies metabolic enzyme as new target for anti-inflammatory therapeutics

A metabolic enzyme that has been studied in cancer biology and is important for T cell function may offer a new target for anti-inflammatory therapeutics, Vanderbilt researchers have discovered.

12 Nov 2021

Study offers genetic clues on the fundamental development of anatomical appearance

Which genes control the defining features that make us look as we do? And how do they make it happen?

11 Nov 2021

Researchers identify a gene in wheat with profound effects on the production of seeds

Scientists from the John Innes Centre have identified a gene that has deep-rooted effects on seed production in wheat.

10 Nov 2021

Genetic analysis reveals the deep homology between fins and limbs

All vertebrates have the same basic body plan: head, spine, four appendages. Those appendages vary greatly in size, shape, and function, of course -; from fins to wings, arms, and legs -; but a new genetic analysis shows that genes that control development at the ends of the appendages share a deep evolutionary history.

9 Nov 2021

Study employs engineered base editors for controllable genome editing

According to a recent study, targeted mutations to the genome can be instituted by splitting specific mutator enzymes and later inducing them to reconstitute.

1 Nov 2021