Antisense News and Research

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Antisense is the non-coding strand in double-stranded DNA. The antisense strand serves as the template for mRNA synthesis.

Study identifies new therapy to treat cystic fibrosis

The process of making proteins from genes is similar to that of a factory, where employees must follow a set of instructions that are both effective and precise.

31 Jan 2022

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

Toxin in potatoes is a divergent of bitter-tasting compound in tomatoes

A multi-institutional collaboration has revealed that α-solanine, a toxic compound found in potato plants, is a divergent of the bitter-tasting α-tomatine, which is found in tomato plants.

26 Mar 2021

Lowering apolipoprotein CIII levels can prevent deleterious effects of a high-fat diet

Consumption of a diet with high fat levels increases the risk of fatty liver, obesity, cardiovascular diseases, and type 2 diabetes.

15 Mar 2021

Researchers develop genetic patch to eliminate problems in hearing cells

They can hear well up to about forty years old, but then suddenly deafness strikes people with DFNA9. The cells of the inner ear can no longer reverse the damage caused by a genetic defect in their DNA.

3 Mar 2021

Investigational antisense medicine lowers disease burden, reduces myeloma cell abundance in mice

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

From UC San Diego 21 Jan 2021

Scientists identify potential targets against coronavirus

Scientists comprehensively studied the RNA genomic structure of the SARS-CoV-2 coronavirus.

11 Nov 2020

Research projects receive BTCA awards to develop new drugs

Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.

From Harvard Medical School 30 Oct 2020

Bioengineers detect the presence of maxRNA on the surface of human cells

Bioengineers have demonstrated that RNA produced by the human genome is found on the surface of human cells.

11 Sep 2020

Fault in RNA quality control system causes haywire production of toxic proteins

Osaka, Japan - Researchers at Osaka University have identified a fault in the RNA quality control system of cells that leads to the haywire production of toxic proteins in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FTLD/ALS).

From Osaka University 25 Aug 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020