Cell Death News and Research

RSS

Mitochondrial Calcium Imbalance Drives Neurodegeneration

Mitochondria are crucial organelles for cellular homeostasis, regulating processes such as ATP production, reactive oxygen species (ROS) management and Ca2+ signaling.

27 Jan 2025

AI-designed proteins revolutionize snakebite treatment

Research highlights the potential of deep learning in creating proteins that neutralize snake venom, offering new solutions for neglected tropical diseases.

24 Jan 2025

Discovery Unlocks New Understanding of Autophagy in Health and Disease

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste.

22 Jan 2025

RNA, Not DNA, Drives Acute Sunburn and Skin Damage

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study by the University of Copenhagen and Nanyang Technological University, Singapore, reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

20 Jan 2025

Study Unveils Surprising Cause of Brain Cell Death in Huntington's Disease

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells.

17 Jan 2025

Understanding RapA's Function in E. coli R-loop Control

From a genetic perspective, it is the worst-case scenario for a bacterium: during transcription, freshly created RNA adheres to its DNA template to form a three-stranded structure called an R-loop.

15 Jan 2025

Fiber Digestion Alters Gene Function with Potential Anti-Cancer Effects

Fiber is well known to be an important part of a healthy diet, yet less than 10% of Americans eat the minimum recommended amount.

10 Jan 2025

Researchers Discover Genetic Markers for PFAS-Induced Neurotoxicity

Per- and polyfluorinated alkyl substances (PFAS) earn their "forever chemical" moniker by persisting in water, soil and even the human brain.

7 Jan 2025

Uncovering Key Differences Between Humans and Mice in Cancer Immunotherapy Targets

“Programmed cell death protein 1,” or PD-1, has been considered a key target in cancer therapies since its discovery in the 1990s.

6 Jan 2025

ALS Stem Cell Model Reveals Increased Susceptibility to Cell Death

Amyotrophic lateral sclerosis (ALS) is a fast-progressing neurodegenerative disease with an average survival time of three years. In ALS, certain types of neurons called motor neurons that are required for muscle contractions die off, leading to progressive paralysis affecting most muscles of the body. The molecular causes of ALS are poorly understood, and effective treatments are missing.

20 Dec 2024

Targeting Cancer with Nanoparticle-Delivered Gene Therapy

Scientists are literally shining a laser on the energy centers of cancer cells in an attempt to harm these sources of power and cause widespread cancer cell death.

16 Dec 2024

Study Reveals Mechanism Behind T Cells' Cancer-Killing Power in Hypoxia

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ineffective.

16 Dec 2024

Researchers Develop Mathematical Definition of Cellular Death

Cellular death is a fundamental concept in the biological sciences. Given its significance though, its definition depends on the context in which it takes place, and lacks a general mathematical definition.

28 Nov 2024

Stanford Researchers Develop New Approach to Make Cancer Cells Self-Destruct

Our bodies divest themselves of 60 billion cells every day through a natural process of cell culling and turnover called apoptosis.

28 Nov 2024

Mitochondria Found to Play Key Role in Balancing Cell Death and Inflammatory Response

Whether cells in the human body survive or die under stress depends, among other things, on their mitochondria.

27 Nov 2024

Versatile Molecule with a New Role in Genome Maintenance

A multi-institutional team of researchers from the Georgia Institute of Technology has uncovered a hitherto unidentified function for RNA.

22 Nov 2024

Study Reveals Key Role of Interleukin-38 in Skin Renewal

The mechanisms underlying skin renewal are still poorly understood. Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer.

19 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

AI and Bioinformatics Reveal Genes Linked to Rheumatoid Arthritis and Osteoporosis

Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.

6 Nov 2024

Necroptosis Emerges as a Key Target in Alzheimer's Disease

Alzheimer's disease is characterized by a progressive loss of nerve cells leading to a decline in memory and cognition. A team of researchers at KU Leuven and VIB explored the molecular sequence of events in this cellular demise and identified specific inhibitors that could prevent the loss of nerve cells in different mouse models of the disease.

1 Nov 2024