Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

Identifying the molecular switch that regulates autophagy in plants

Autophagy, commonly known as “self-eating,” is a cellular quality control mechanism that relieves the cell of protein aggregates and damaged organelles. This system is inert under ordinary conditions and is only activated in the presence of persistent cellular stress.

13 Feb 2023

Deubiquitinating enzymes vital for endosomal transport identified

The University of Konstanz’s Plant Physiology and Biochemistry research group has discovered previously unrecognized molecular mechanisms by which plants acclimatize to their environment—vital basic knowledge in times of climate change.

28 Nov 2022

Delicate strategy employed by pathogens to suppress pyroptosis

Mycobacterium tuberculosis (Mtb), the bacteria that causes tuberculosis (TB), continues to be a major infectious threat to global public health.

18 Oct 2022

Researchers propose a way to identify Chlamydia, a deadly bacterial disease

Chlamydia, the most common bacterial infection associated with sexually transmitted diseases, hides inside human cells using a cloaking mechanism to avoid detection and destruction.

9 Sep 2022

SLFN11’s surveillance part in protein homeostasis

On July 25th, 2022, a new study perspective called “SLFN11’s surveillance role in protein homeostasis” was published in Volume 9 of Oncoscience.

8 Aug 2022

Scientists create new live-attenuated influenza vaccine technique over pathogens

The use of attenuated, live viruses as vaccines is a potential method to minimize the effects of viral infectious diseases, such as influenza.

8 Jul 2022

OTUD3 shows opposing effects in innate immunity to RNA and DNA viruses

The identification of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) is the first step in initiating an immune response to viral infection.

13 Jun 2022

Study provides new knowledge on the influence of membrane proteins on plant growth

Ubiquitin is a tiny regulatory protein that can be present in most eukaryotic cells. It is important for changing the function of other proteins, and it is especially important for protein breakdown and localization inside the cell. Ubiquitin regulates these actions through ubiquitination (attaching to and detaching from a target protein).

6 Jun 2022

Proximity-dependent biotinylation helps analyze protein interaction

Protein degraders, which cause target proteins to break down, are thought to be the “next-generation drugs” because they may eliminate disease-causing proteins from cells.

9 Mar 2022

First molecular images of enzyme may help solve the mystery cause of hereditary neurodegenerative diseases

WEHI researchers have produced the first molecular images of an enzyme that controls proteins to signal and communicate with each other in human cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 13 Jan 2022

Scientists discover new Senp5S protein with crucial role in brain development

Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from the embryonic stage, brain development is facilitated by the differentiation of neurons (brain cells).

12 Jan 2022

Experts analyze key protein complexes involved in DNA replication and repair

Cryogenic electron microscopy (cryo-EM) allows scientists to investigate the assembly of DNA replication machinery where DNA is damaged.

25 Nov 2021

Robust electron microscope provides mechanistic insight into protein degradation

Proteins are the building blocks of all living things and numerous studies are carried out to determine how these proteins are made and their function.

19 Nov 2021

New gene critical for daily behavioral rhythms discovered

Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type.

16 Nov 2021

Researchers identify a manipulation molecule produced by bacteria to hijack plant development

A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops.

20 Sep 2021

Research provides novel insight into plant chloroplasts and proteins within

A recent study provides insight into plant chloroplasts and the proteins inside them.

17 Sep 2021

Research provides a detailed 'proteogenomic' view of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

6 Aug 2021

Study on protein complex could help support cancer prevention efforts, drug development

Researchers have used sophisticated imaging technology to offer unmatched insights into the BRCA1-BARD1 protein complex.

29 Jul 2021

Yeast study reveals a protein involved in gross chromosomal rearrangements

Gross chromosomal rearrangements--where portions of the genome become moved, deleted, or inverted--can lead to cell death and diseases such as cancer in complex multicellular organisms.

23 Jul 2021