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Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Innovative method to quickly identify bacteria in fluids

Shine a laser on a drop of blood, mucus, or wastewater, and the light reflecting back can be used to positively identify bacteria in the sample.

3 Mar 2023

Uncovering the complete 3D structure of p53 protein

By inducing cell repair or self-destruction, the tumor suppressor protein p53, often known as “the guardian of the genome,” shields the body’s DNA from daily stress or long-term damage.

2 Mar 2023

Novel way to block the death of nerve cells in MND

Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD).

2 Mar 2023

New technique may offer a pathway to treat undruggable diseases

Certain diseases, including Alzheimer's, are currently considered "undruggable" because traditional small molecule drugs can't interfere with the proteins responsible for the illnesses.

2 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

Five Alarm Bio, Focused on Minimising the Effects of Aging in Humans, Raises Seed Investment

Investors include Cambridge Angels, Meltwind, o2h Ventures, SyndicateRoom, and Angel investors, with support from KPMG Acceleris.

From Five Alarm Bio 28 Feb 2023

Nanosatellite paves the way for developing RNA-based medicines

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and satellites, and have studied their 3D structure and dynamics with advanced nanotechnological methods.

28 Feb 2023

Study elucidates the cellular changes caused by exposure to adversity during childhood

A new brain connection discovered by University of California, Irvine researchers can explain how early-life stress and adversity trigger disrupted operation of the brain's reward circuit, offering a new therapeutic target for treating mental illness. Impaired function of this circuit is thought to underlie several major disorders, such as depression, substance abuse and excessive risk-taking.

28 Feb 2023

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Scientists discover two ways to preserve diseased upper motor neurons in ALS

Northwestern Medicine scientists have discovered two ways to preserve diseased upper motor neurons that would normally be destroyed in ALS, based on a study in mice. Upper motor neurons initiate movement, and they degenerate in ALS.

24 Feb 2023

Novel model system helps studying human ovarian biology

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied. Scientists have been working on creating in vitro models of human ovaries so that we can learn more about them and develop treatments for ovarian conditions, but most existing models use a combination of human and mouse cells, which do not faithfully replicate human ovary functions and take a long time to grow in the lab.

22 Feb 2023

Study reveals how chloroplast ATP synthase regulates ATP production in organisms

ATP, the compound essential for the functioning of photosynthetic organisms such as plants, algae, and cyanobacteria, is produced by an enzyme called "chloroplast ATP synthase" (CFoCF1).

22 Feb 2023

New insights into the mechanism underlying the immunomodulatory effects of polyphenols

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

New technique uses amino acids to cure meat and poultry products

Imagine your favorite cured meat like beef jerky, pepperoni or bacon without any added sodium nitrite from any source currently necessary for color and shelf life. Wes Osburn, Ph.D., is doing exactly that.

22 Feb 2023

DNA methylation for precise gene expression regulation

If the genome is viewed as a guidebook for how a cell should operate, then annotations, highlights, and bookmarks are included on every page.

21 Feb 2023

New biomarker helps identify biological age

Once considered to be incompetent in encoding proteins due to their simple monotonous DNA repetitions, tiny telomeres at the tips of human chromosomes now appear to have a powerful biological function that could help better understand cancer and aging.

21 Feb 2023

Accelerating the structure-guided discovery of chemogenetic tools

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells. One way is by using a tool called DREADDs, which stands for Designer Receptors Activated by Designer Drugs.

21 Feb 2023

Unique approach harnesses plant molecules like chlorophyll to harvest solar energy

Our current solar panels aren't very efficient; they are only able to convert up to about 20 percent of the sun's energy into electricity. As a result, to generate a lot of electricity, the panels require a lot of space-;sometimes leading forests to be cut down or farms to be replaced by solar. If solar panels were more efficient, much smaller panels could make the same amount of electricity, and wouldn't claim as much land.

20 Feb 2023

Molecule News and Research

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Innovative method to quickly identify bacteria in fluids

Uncovering the complete 3D structure of p53 protein

Novel way to block the death of nerve cells in MND

New technique may offer a pathway to treat undruggable diseases

Novel framework provides solutions to evade detoxification networks

Five Alarm Bio, Focused on Minimising the Effects of Aging in Humans, Raises Seed Investment

Nanosatellite paves the way for developing RNA-based medicines

Study elucidates the cellular changes caused by exposure to adversity during childhood

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Scientists discover two ways to preserve diseased upper motor neurons in ALS

Novel model system helps studying human ovarian biology

Study reveals how chloroplast ATP synthase regulates ATP production in organisms

New insights into the mechanism underlying the immunomodulatory effects of polyphenols

New technique uses amino acids to cure meat and poultry products

DNA methylation for precise gene expression regulation

New biomarker helps identify biological age

Accelerating the structure-guided discovery of chemogenetic tools

Unique approach harnesses plant molecules like chlorophyll to harvest solar energy

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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