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Chemists identify effective inhibitors to block the uptake of SARS-CoV-2

The cell membrane is impermeable to viruses: to get inside and infect a cell, they use a range of strategies to exploit the cellular and biochemical properties of the membranes.

23 Nov 2020

Gaining new insights into bacterial pneumonia

Jacqueline Kimmey speaks to AZoLifeSciences about her research into bacterial pneumonia and the genes that drive its spread from the lungs into the blood.

From University of California Santa Cruz 23 Nov 2020

Scientists discover new functions of key cellular machine involved in human cancers

Utah scientists have discovered new functions of a key cellular machine that regulates gene packaging and is mutated in 20% of human cancers. The study was published in print today in the journal Molecular Cell.

20 Nov 2020

Vibrational motions of spike proteins correlate with infectivity, lethality of SARS-CoV-2 virus

When someone struggles to open a lock with a key that doesn't quite seem to work, sometimes jiggling the key a bit will help. Now, new research from MIT suggests that coronaviruses, including the one that causes Covid-19, may use a similar method to trick cells into letting the viruses inside.

From Massachusetts Institute of Technology (MIT) 20 Nov 2020

Pairs of antibodies may be more effective at preventing and treating COVID-19

Pairs of antibodies may be more effective than single antibodies at preventing and treating COVID-19, according to a new study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University in New York.

20 Nov 2020

Study may lead to new strategies that minimize inflammatory reactions after cell transplants

The term leukaemia is used to describe a group of malignant diseases of the haematopoietic system, in which precursors of the white blood cells (leucocytes) proliferate uncontrollably.

20 Nov 2020

Scientists elucidate the structure of ABC transporter protein

A high concentration of salt or sugar in the environment will dehydrate microorganisms and stop them from growing.

19 Nov 2020

Study shows how brain protein helps pancreatic cancer cells to survive

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

19 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Novel DNA-based nanogel for targeted delivery of chemotherapeutics

Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells.

19 Nov 2020

New method could more sensitively detect circulating tumor cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients.

19 Nov 2020

Study shows CRISPR/Cas9 system can effectively treat metastatic cancers

Researchers have shown that the advanced CRISPR/Cas9 system is extremely effective in curing metastatic cancers.

19 Nov 2020

Researchers use new technique to visualize the world of lipid dynamics

The potential to “see” the inner mechanisms of structures provides the promise of developments in the diagnosis and treatment of various diseases.

19 Nov 2020

Study outlines transient prospective stages in development of neural crest cells

Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos.

19 Nov 2020

Gold nanoparticles put spotlight on small drug molecules in live cells

Successful drug development has a significant impact on people's quality of life worldwide. Being able to track how molecules get into target cells, and observing what they do when they are inside, is key to identifying the best candidates.

From Osaka University 19 Nov 2020

Study reveals metabolic signaling pathways that influence key immune cells

Effector regulatory T cells, also known as eTreg cells, are a specialized subset of white blood cells that maintain the immune system.

18 Nov 2020

New protein imaging technique may lead to advanced tissue analysis

Researchers have defined a new protein imaging technique that may result in novel discoveries in disease, cell analysis, biological tissue, and more.

18 Nov 2020

Researchers explain how tissue tension influences the orientation of cell division

The human body experiences many cell divisions during a lifetime. Such a biological process is crucial to form and sustain organs and tissues inside the body.

18 Nov 2020

Somatic mutation acts as natural gene therapy in patients with GATA2 deficiency

Researchers affiliated with the Center for Cell-Based Therapy (CTC) in Ribeirão Preto, Brazil, have identified for the first time a non-hereditary mutation in blood cells from a patient with GATA2 deficiency, a rare autosomal disease caused by inherited mutations in the gene that encodes GATA-binding protein 2 (GATA2).

18 Nov 2020