Efficacy News and Research

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Novel vaccine uses patient's own tumor cells to train the immune system to fight cancer

Immunotherapy, which recruits the body's own immune system to attack cancer, has given many cancer patients a new avenue to treat the disease.

25 Mar 2021

Disease-driving B cells play a role in non-alcoholic fatty liver disease

A study by researchers proposes that disease-driving B cells—a kind of white blood cell—have a role in the development of non-alcoholic fatty liver disease.

23 Mar 2021

New high-throughput system for testing drug candidates to treat neurodegenerative diseases

On the basis of a license agreement with the German Center for Neurodegenerative Diseases (DZNE) and the Leibniz Institute of Polymer Research Dresden (IPF), the Dresden-based start-up "Neuron-D GmbH" is developing a high-throughput system for testing drug candidates to treat neurodegenerative diseases.

19 Mar 2021

Seaweed supplement in cattle diet effective at reducing greenhouse gases

A bit of seaweed in cattle feed could reduce methane emissions from beef cattle as much as 82 percent, according to new findings from researchers at the University of California, Davis.

18 Mar 2021

New substance could improve the treatment of drug-resistant cancers

A new substance could improve the treatment of persistent cancers. Researchers at Martin Luther University Halle-Wittenberg and the University of Greifswald have developed a new inhibitor that makes drug-resistant tumor cells respond again to chemotherapy.

9 Mar 2021

Catechin-type flavonoid compounds in tea relax blood vessels by activating ion channel proteins

A new study from the University of California, Irvine shows that compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall.

9 Mar 2021

Virtual clinical trials could transform the development of new drugs

New cutting-edge research undertaken at the University of Leicester could revolutionize the way new drugs are developed and the way patients are cared for, through a pioneering new approach using virtual clinical trials.

8 Mar 2021

Mutant peptides derived from SARS-CoV-2 hamper activation of CD8+ killer T cells

A deep sequencing study of 747 SARS-CoV-2 virus isolates has revealed mutant peptides derived from the virus that cannot effectively bind to critical proteins on the surface of infected cells and, in turn, hamper activation of CD8+ killer T cells that recognize and destroy these infected cells.

5 Mar 2021

Three new COVID-19 variants can evade antibodies that act against original virus

New research at Washington University School of Medicine in St. Louis indicates that three new, fast-spreading variants of the virus that cause COVID-19 can evade antibodies that work against the original form of the virus that sparked the pandemic.

5 Mar 2021

Engineered safety switch reduces CAR-T immunotherapy-related side effects

UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur.

5 Mar 2021

Natural compound acts as reversible male contraceptive pill

Researchers have developed a novel approach that has resulted in the discovery of a natural compound that acts as a male contraceptive agent.

5 Mar 2021

Researchers find effective combination of therapies for managing mitochondrial disease

Researchers have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders.

3 Mar 2021

Researchers sequence 64 human genomes at high resolution

After the successful conclusion of the “Human Genome Project”, an international research team has sequenced a total of 64 human genomes at high resolution.

26 Feb 2021

Genes could help determine the intensity of neutralizing antibodies to COVID-19 virus

While neutralizing antibodies form in less than two weeks of a COVID-19 infection, their intensity and durability can differ from one individual to another.

22 Feb 2021

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

From UC San Diego 19 Feb 2021

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

18 Feb 2021

Machine learning approach to identify drugs that could be repurposed to fight Covid-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments.

16 Feb 2021

New tool reveals potentially risky DNA alterations at site of CRISPR gene repair

Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease.

12 Feb 2021

Study reveals genetic factors linked to COVID-19 susceptibility in people with Down syndrome

A study reveals the genetic factors that may expose or protect people with Down syndrome from SARS-CoV-2 infection, as well as the prognosis of COVID-19.

9 Feb 2021

Cancer survivors face barriers in maintaining a healthy diet

New research and analysis appearing in the Journal of the Academy of Nutrition and Dietetics, published by Elsevier, highlights the barriers cancer survivors face in maintaining a healthy diet, as well as the role nutrition may play in cancer risk and treatment.

4 Feb 2021

Efficacy News and Research

Novel vaccine uses patient's own tumor cells to train the immune system to fight cancer

Disease-driving B cells play a role in non-alcoholic fatty liver disease

New high-throughput system for testing drug candidates to treat neurodegenerative diseases

Seaweed supplement in cattle diet effective at reducing greenhouse gases

New substance could improve the treatment of drug-resistant cancers

Catechin-type flavonoid compounds in tea relax blood vessels by activating ion channel proteins

Virtual clinical trials could transform the development of new drugs

Mutant peptides derived from SARS-CoV-2 hamper activation of CD8+ killer T cells

Three new COVID-19 variants can evade antibodies that act against original virus

Engineered safety switch reduces CAR-T immunotherapy-related side effects

Natural compound acts as reversible male contraceptive pill

Researchers find effective combination of therapies for managing mitochondrial disease

Researchers sequence 64 human genomes at high resolution

Genes could help determine the intensity of neutralizing antibodies to COVID-19 virus

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

Machine learning approach to identify drugs that could be repurposed to fight Covid-19

New tool reveals potentially risky DNA alterations at site of CRISPR gene repair

Study reveals genetic factors linked to COVID-19 susceptibility in people with Down syndrome

Cancer survivors face barriers in maintaining a healthy diet

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