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New technique to hunt down mutations that cause cancer drug resistance

Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests.

11 Aug 2021

Restoring cholesterol levels could be a new therapeutic approach for neurodegenerative diseases

Scientists have found that the brain lacks the ability to maintain the cholesterol-rich myelin sheath that insulates neurons when a protein is absent.

From National University of Singapore (NUS) 10 Aug 2021

Study discovers link between corticosteroid receptors and hippocampal neuroplasticity, ciliary genes

Chronic stress is a well-known cause for mental health disorders. New research has moved a step forward in understanding how glucocorticoid hormones ('stress hormones') act upon the brain and what their function is.

9 Aug 2021

Scientists show how lab-grown beating heart cells are vulnerable to SARS-CoV-2 infection

Cambridge scientists have grown beating heart cells in the lab and shown how they are vulnerable to SARS-CoV-2 infection. In a study published in Communications Biology, they used this system to show that an experimental peptide drug called DX600 can prevent the virus entering the heart cells.

6 Aug 2021

Cytokines play a role in regulation of beige fat

An immune signal promotes the production of energy-burning "beige fat," according to a new study publishing August 5th in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues.

6 Aug 2021

Study explores the effectiveness of a natural protein against colon cancer cells

Scientists and faculty of Vanderbilt University are in search of the “Achilles’ heel” of cancer cells that survive initial chemotherapy.

From Vanderbilt University 5 Aug 2021

Study: Biomarker can predict response to immunotherapies in breast cancer patients

A biomarker that has proven to be a predictor for response to immunotherapies in melanoma patients also has clinical relevance for breast cancer patients, according to a new study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

28 Jul 2021

Study reveals SARS-CoV-2 variant is less sensitive to inhibition by antibodies

SARS-CoV-2 is still a major threat to humankind. The constant emergence of variants makes the threat made by the virus difficult to estimate. The SARS-CoV-2 variant B.1.617 spread in India and gave rise to the Delta variant, B.1.617.2, which is now dominant in numerous countries.

23 Jul 2021

Natto, a Japanese fermented soybean dish, may hold the key to COVID-19 treatment

Natto is a fermented soybean dish usually served by the Japanese for breakfast. Although it actually originated at the turn of the last millennium, it could be the key to a modern problem—COVID-19—reports a new cell-culture-based study.

23 Jul 2021

Research identifies vitamin C as a key ingredient for immune cell function

A new study has now identified that it is not possible to generate stable regulatory T cells without Vitamin C or enzymes called TET proteins as much as how one cannot make a banana split without bananas.

23 Jul 2021

SARS-CoV-2 variant B.1.617 can infect lung and intestinal cells more efficiently than the original virus

SARS-CoV-2 still poses major challenges to mankind. The frequent emergence of mutant forms makes the threat posed by the virus difficult to predict.

22 Jul 2021

L452R mutation of SARS-CoV-2 spike protein is involved in cellular immunity evasion

A research team has demonstrated that the L452R mutation of the SARS-CoV-2 spike protein plays a role in cellular immunity evasion.

21 Jul 2021

Emerging variants of COVID-19 could be treated with a new anticoagulant drug

The capacity of the COVID-19 virus’s spikes to bind to human cells may be hampered by molecules from the same family as the anticoagulant medication heparin.

9 Jul 2021

Castration of male sheep delays aging of DNA, study shows

Most of us are familiar with the fact that women live longer than men. But fellas, if we told you there was one thing that could be done to increase your lifespan, would you do it?

7 Jul 2021

Mutations on SARS-CoV-2 spike proteins create antibody-resistant variants

Researchers have identified how mutations on the SARS-CoV-2 spike protein separately create variants that are potentially resistant to antibodies.

1 Jul 2021

Higher density mediates receptor activation in immune cells

Researchers from the University of Southampton have discovered how tumor necrosis factor receptors, a crucial class of immune receptors, are activated.

28 Jun 2021

Mayo Clinic researchers examine potential new CAR-T cell treatment for multiple myeloma

Researchers at Mayo Clinic Cancer Center are studying a potential new chimeric antigen receptor-T cell therapy (CAR-T cell therapy) treatment for multiple myeloma.

28 Jun 2021

New nanobodies could fight against SARS-CoV-2 variants

Looking for a new strategy in the long-running battle against the SARS-CoV-2 virus, researchers have developed nanobodies.

23 Jun 2021

New method to control the complex communication network of cells

A study has proposed a new method for developing novel drugs based on the suppression of tyrosine kinase enzymes.

21 Jun 2021

Genetically engineering NK cells can target and kill glioblastoma stem cells

Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity.

18 Jun 2021

Receptor News and Research

New technique to hunt down mutations that cause cancer drug resistance

Restoring cholesterol levels could be a new therapeutic approach for neurodegenerative diseases

Study discovers link between corticosteroid receptors and hippocampal neuroplasticity, ciliary genes

Scientists show how lab-grown beating heart cells are vulnerable to SARS-CoV-2 infection

Cytokines play a role in regulation of beige fat

Study explores the effectiveness of a natural protein against colon cancer cells

Study: Biomarker can predict response to immunotherapies in breast cancer patients

Study reveals SARS-CoV-2 variant is less sensitive to inhibition by antibodies

Natto, a Japanese fermented soybean dish, may hold the key to COVID-19 treatment

Research identifies vitamin C as a key ingredient for immune cell function

SARS-CoV-2 variant B.1.617 can infect lung and intestinal cells more efficiently than the original virus

L452R mutation of SARS-CoV-2 spike protein is involved in cellular immunity evasion

Emerging variants of COVID-19 could be treated with a new anticoagulant drug

Castration of male sheep delays aging of DNA, study shows

Mutations on SARS-CoV-2 spike proteins create antibody-resistant variants

Higher density mediates receptor activation in immune cells

Mayo Clinic researchers examine potential new CAR-T cell treatment for multiple myeloma

New nanobodies could fight against SARS-CoV-2 variants

New method to control the complex communication network of cells

Genetically engineering NK cells can target and kill glioblastoma stem cells

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