Autophagy News and Research

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Autophagy is a normal process in which a cell destroys proteins and other substances in its cytoplasm (the fluid inside the cell membrane but outside the nucleus), which may lead to cell death. Autophagy may prevent normal cells from developing into cancer cells, but it may also protect cancer cells by destroying anticancer drugs or substances taken up by them.

Scientists demonstrate a new function of an enzyme that connects to age-related diseases

Aging and age-related diseases present a complex challenge to biomedical researchers.

20 Jul 2022

Research associates autophagy and age-related nervous system degradation

The in-built mechanism of recycling dead or poisonous material to preserve the health of human cells is critical to general health.

20 Apr 2022

Cellular recycling system of autophagy likely to help in wound repair

In the fruit fly Drosophila, a team led by Maria Leptin discovered that autophagy, a stress response process in cells, plays a significant role in wound repair.

14 Mar 2022

New study uncovers potential driver of Parkinson’s disease

Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.

24 Feb 2022

Study identifies respiratory syncytial viral protein that mediates RSV-induced autophagy

A viral protein might contain information that could be used to avoid pneumonia due to the body’s overactive response to respiratory viruses, such as COVID-19.

20 Jan 2022

Study uncovers mechanism that triggers cancer cell death

Scientists recently pinpointed the mechanism by which inhibitors of the ERK5 protein kinase diminish cancer cell proliferation and trigger their death.

23 Dec 2021

Metabolic restoration could provide natural protection against HIV

The human immunodeficiency virus (HIV-1) particularly attacks CD4 lymphocytes, a type of white blood cell considered to be the conductor of the immune system.

19 Oct 2021

Intermittent fasting slows aging and increases longevity in fruit flies, study shows

Whether intermittent fasting is called the 5:2 diet or the 16/8 method, celebrities swear that these eating regimens are a great way to lose weight. Fasting is now trendy, but real science backs up claims that fasting two days a week or restricting eating to an eight-hour window each day leads to weight loss.

30 Sep 2021

NANOG protein ameliorates primary hallmarks of cellular senescence, says study

Researchers have found that a protein named after the mythical land of youth in Irish folklore is efficient at reversing skeletal muscle cells aging.

20 Sep 2021

Researchers identify inhibitor that converts immune cold cancer to red hot ones

Scientists headed by the University of Michigan Rogel Cancer Center converted an immune cold cancer into one that responds to immunotherapy.

4 Aug 2021

Researchers profile lysosomes based on single metabonomic information

For the first time, researchers have achieved lysosome typing based on single lysosome metabonomic data.

30 Jun 2021

New 3Cs multiplex approach enables the study of the effect of genetic changes

Dr Manual Kaulich’s team at Goethe University has developed a new 3Cs multiplex approach that permits the effect of genetic alterations in any two genes to be investigated simultaneously in cell cultures.

25 Jun 2021

Polyamines with known functionalities can treat age-related disorders

According to a new scientific study, recently published in the Nature Catalysis journal, baker's yeast can be engineered and improved to create polyamines and polyamine analogs to address major problems in both the health and agriculture sectors.

21 Jun 2021

Study sheds new light on age-related diseases

Researchers from Sanford Burnham Prebys have explored the intricacies of autophagy to get a better understanding of the process.

21 Jun 2021

Study shows that autophagy plays a key role in messenger RNA degradation

Autophagy is essential in messenger RNA (mRNA) degradation, according to researchers from the Tokyo Institute of Technology (Tokyo Tech).

27 Apr 2021

Study highlights the importance of autophagy in gene regulation

A fine balance between the production and degradation of biomolecules is required for optimal cell function. Autophagy is a mechanism through which cells break down and recycle their own components.

20 Apr 2021

High expression of cell death genes linked to increased risk of dying early from lung cancer

Patients with a high number of genes most associated with pathways that lead to cell death in lung cancer are at increased risk of dying early from their disease, researchers report.

6 Apr 2021

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

12 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

Study reveals molecular details of how SARS-CoV-2 infects cells

The molecular details of how SARS-CoV-2 enters cells and infects them are still not clear. Researchers at Uppsala University have tested the bioinformatic predictions made by another research group and have identified receptors that could be important players in the process.

9 Feb 2021