Genome Editing News and Research

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Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

GSE3 Gene Editing Paves the Way for Mechanized Hybrid Rice Breeding

In a study published in Nature Plants, Prof. LI Yunhai from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences and Profs. ZHU Xudong and WANG Yuexing from the China National Rice Research Institute have identified an ideal small grain size gene, GSE3.

5 Jun 2024

CRISPR/Cas Biosensors Address Sensitivity and Specificity Challenges in Detection

The mechanisms of CRISPR-Cas-based biosensors.

5 Jun 2024

Sphere Fluidics Launches Cyto-CellectPLUS to Accelerate Cell Line Development Workflows

Sphere Fluidics, a leading provider of innovative microfluidics-based solutions for single-cell analysis and isolation, today announced the launch of Cyto-Cellect®PLUS.

From Sphere Fluidics Limited 5 Jun 2024

Study Reveals Allele-Specific DNA Methylation in Hybrid Poplar Regeneration

Understanding plant regeneration at the molecular level is pivotal for advancements in genetic transformation and genome editing.

27 May 2024

SPT Labtech’s Firefly® Liquid Handler Chosen by Colossal Biosciences to Accelerate NGS Capabilities in Fight Against Species Extinction and Biodiversity Loss

SPT Labtech, a global leader in the design, development and manufacture of automated instrumentation and consumables for life science applications, announces that its firefly liquid handling platform has been selected by Colossal Biosciences to enhance its Next Generation Sequencing (NGS) capabilities.

From SPT Labtech 24 May 2024

Multiplexed Orthogonal Base Editors for Precise Mutation Modeling

The human genome consists of around 3 billion base pairs and humans are all 99.6% identical in their genetic makeup.

23 May 2024

Viruses Offer Efficient Delivery for Precise Plant Breeding

The application of genome editing in plant molecular breeding is hampered by the lack of straightforward and efficient methods for introducing genome editing reagents into plants, despite the technology's great potential.

20 May 2024

New Tool Precisely Edits Epigenetic Modifications

Powerful epigenetic editing technology was developed as a result of research by the Hackett group at EMBL Rome. This technology allows for the precise programming of chromatin modifications.

10 May 2024

Small RNA-Binding Protein Promotes Prime Editing Efficiency

Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to 'genome surgery'.

23 Apr 2024

Meta-Analysis of ABA-Related Stress Responses Reveals Novel Gene Targets in Thale Cress

Plants can be temperamental. Even weeds along the side of highways or pushing their way up in the cracks of concrete sidewalks can get stressed out by dehydration, cold, excess salt and more.

13 Apr 2024

New Study Unveils Mechanism Behind Mice Ovary Development

Scientists at the Francis Crick Institute have provided insight into the proteins governing the development of mice's ovaries both prenatally and postnatally. This might help comprehend the progression of female infertility.

25 Mar 2024

New Approach to Constructing Human Artificial Chromosomes Avoids Unintended Multimerization

Constructing human artificial chromosomes (HACs) in budding yeast overcomes the long-standing problem of uncontrolled multimerization – the rampant joining of similar molecules – and results in HACs that are large, stable, and structurally well-defined, researchers report.

22 Mar 2024

Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

New research presented early ahead of this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) from a team of researchers in the Netherlands shows how the latest CRISPR-Cas gene editing technology can be used to eliminate all traces of the HIV virus from infected cells in the laboratory, raising hopes of a cure.

20 Mar 2024

New CRISPR Method Allows Comprehensive Screening of Cancer Mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways -; some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

13 Mar 2024

Evolutionary Mystery Identified in Genome of Plants

Cold Spring Harbor Laboratory (CSHL) has enabled the significant advancement of plant genomics through its involvement in sequencing the first plant genome. Now, the same research laboratory hopes to address why introducing the same mutation in different crops does not always result in the desired traits.

5 Mar 2024

Retrotransposon-Based PRINT Technique Holds Potential for Precise Gene Insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

22 Feb 2024

Unleashing the Potential of CRISPR-COPIES

The last ten years have seen tremendous advancements in CRISPR/Cas systems. These precise genome editing tools can be used for more than just gene therapy and transgenic crop development.

13 Feb 2024

Fruit Flies Shed Light on Evolution Driven by Sexual Selection

Despite their small size, fruit flies have contributed much to the understanding of the genetic foundation of the fast evolution of male external genitalia through sexual selection

5 Feb 2024

Unlocking Precise DNA Modifications With Cas12a Innovations

Caixia Gao’s group at the Chinese Academy of Sciences’ Institute of Genetics and Developmental Biology has created a number of new prime editors based on the Cas12a protein, broadening the applications and targeting range of precision genome editing, as reported in a study published in Nature Biotechnology.

12 Jan 2024