Splicing News and Research

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Novel Gene Therapy Approach Delivers Large Genes

A breakthrough by University of Zurich (UZH) researchers introduces a versatile technique for efficiently and safely delivering substantial genes, holding significant promise for therapeutic applications.

25 Oct 2023

New Neural Network Sheds Light on RNA Splicing Process

A team of New York University computer scientists has created a neural network that can explain how it reaches its predictions.

10 Oct 2023

Explaining How Neural Networks For Genomics Work

A neural network that can explain how it generates predictions has been developed by a group of computer scientists from New York University.

9 Oct 2023

The Last Piece of Our Genome: Sequencing the Y Chromosome

A full sequence of the Y chromosome, a feat that has challenged scientists for years, has been accomplished for the first time. In this interview, we speak to Dylan Taylor about this impactful research and how it may shape our understanding of human genetics.

1 Sep 2023

New Findings May Provide Useful Therapeutic Approach for Treating Breast Cancer Patients

A new editorial paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer?"

21 Aug 2023

Targeting Long-read RNA Sequencing with Low-Cost Technology

Researchers at the Children’s Hospital of Philadelphia (CHOP) have created a flexible and affordable approach for targeted sequencing of full-length RNA molecules, which might hasten the development of novel diagnostics and therapies.

16 Aug 2023

The Future of Nanobiotechnology: Ethical Considerations

Prosthetics moved by thoughts. Targeted treatments for aggressive brain cancer. Soldiers with enhanced vision or bionic ears.

13 Jul 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

A High-Throughput Assay for Identifying and Validating ECHS1 Enzyme Genetic Variants

The enzyme variations of mitochondrial enoyl-CoA hydratase short-chain 1 (ECHS1) are dysfunctional. In Japan, they are mostly responsible for mitochondrial disease.

19 May 2023

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Scripps Research scientists have developed a new strategy for identifying small molecules that can change the function of proteins, offering a promising path for discovering targeted drugs.

28 Apr 2023

Meta-scale approach to quantifying the protein variants in the human body

A key conundrum in biology is why many very simple creatures, such as the widely studied worm C. elegans, have almost as many genes as the human genome, which has about 20,000 genes.

27 Mar 2023

Revealing how hematopoietic stem cells acquire malignant traits in cancer

Scientists from Lund University’s Faculty of Medicine have discovered a novel mechanism connecting ribonucleic acid (RNA) metabolism to the development of leukemia in patients with myelodysplastic syndrome (MDS).

23 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

New puzzle challenge taps into the intelligence of Eterna’s users to advance RNA therapeutics

Researchers at UC Santa Cruz working to develop novel RNA-based medicines are teaming up with a new group of collaborators-;players of the online game Eterna.

22 Feb 2023

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

17 Feb 2023

Splicing News and Research

Novel Gene Therapy Approach Delivers Large Genes

New Neural Network Sheds Light on RNA Splicing Process

Explaining How Neural Networks For Genomics Work

The Last Piece of Our Genome: Sequencing the Y Chromosome

New Findings May Provide Useful Therapeutic Approach for Treating Breast Cancer Patients

Targeting Long-read RNA Sequencing with Low-Cost Technology

The Future of Nanobiotechnology: Ethical Considerations

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

A High-Throughput Assay for Identifying and Validating ECHS1 Enzyme Genetic Variants

Mirror-Image Versions of a Small Molecule Pave New Way for Cancer Drug Discovery

Meta-scale approach to quantifying the protein variants in the human body

Revealing how hematopoietic stem cells acquire malignant traits in cancer

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

New puzzle challenge taps into the intelligence of Eterna’s users to advance RNA therapeutics

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Pancreatic islet microexons play key role in islet function and glucose homeostasis

Novel, more accurate computational tool for long-read RNA sequencing developed

New computational tool for long-read RNA sequencing

New toolkit enables researchers to map an individual’s RNA data to a much richer reference

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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