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Pioneer transcription factors help turn on key genes that give cells unique properties

Biologists have long wondered how complex organisms contain a variety of dramatically different types of cells with specialized functions, even though all of those cells are genetically identical.

25 Jan 2021

New protocol identifies mismatch repair deficiency

Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in the colon, endometrial, and other cancers.

22 Jan 2021

New multidimensional model of trophoblast motility uses a functionalized hydrogel

Trophoblast cells, which surround the developing blastocyst in early pregnancy, play an important role in implantation in the uterine wall.

24 Dec 2020

Innovative gene therapy approach for regeneration of functional new neurons

Spinal cord injury (SCI) often causes disability and seriously compromises quality of life. While decades of research have made significant progress in axonal regeneration after SCI, most of the interventions have not been translated into clinical therapies.

18 Dec 2020

Study elucidates genes responsible for Glioblastoma invasiveness

One of the hallmarks of Glioblastoma (GBM), the most aggressive type of brain cancer, is its high invasive capacity, which leads to its expansion into the normal brain tissue.

14 Dec 2020

Research reveals fundamental insights into the causes of severe birth defects

Research by Kai Jiao, M.D., Ph.D., and colleagues at the University of Alabama at Birmingham and in Germany has yielded fundamental insights into the causes of severe birth defects known as CHARGE syndrome cases. These congenital birth defects include severe and life-threatening heart malformations.

3 Dec 2020

Gaining new insights into bacterial pneumonia

Jacqueline Kimmey speaks to AZoLifeSciences about her research into bacterial pneumonia and the genes that drive its spread from the lungs into the blood.

From University of California Santa Cruz 23 Nov 2020

Myeloid cell can suppress the immune response to tumor cells

For a long time, researchers had believed that the brain reduces inflammation by protecting itself from an aggressive immune response.

28 Oct 2020

Researchers examine cooperative tumorigenic effects of targeted deletions of tumor suppressors

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

12 Oct 2020

How Artificial Intelligence aids Gene Activation Discovery

Professor James Kadonaga speaks to AZoLifeSciences about his research into gene activation, and how artificial intelligence can help to aid its discovery.

From UC San Diego 18 Sep 2020

Highly expressed DDX1 gene is associated with poor survival of neuroblastoma

Neuroblastoma, is often diagnosed during childhood. It is responsible for causing 15% of all malignancy death in childhood.

14 Sep 2020

Study reveals efficient expression system for production of coagulation factor XIIIa

Many reports illustrate that Coagulation factor XIIIa (FXIIIa) has diverse and crucial functions in thrombus for¬mation and stability.

29 Jul 2020

Epigenomic data can help characterize genes that play key role in cancer progression

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

From Massachusetts Institute of Technology (MIT) 24 Jul 2020

New spatial mapping method pinpoints new potential therapeutic targets for lupus

A team of researchers from Children's Hospital of Philadelphia used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders.

9 Jul 2020

Promoter News and Research

Pioneer transcription factors help turn on key genes that give cells unique properties

New protocol identifies mismatch repair deficiency

New multidimensional model of trophoblast motility uses a functionalized hydrogel

Innovative gene therapy approach for regeneration of functional new neurons

Study elucidates genes responsible for Glioblastoma invasiveness

Research reveals fundamental insights into the causes of severe birth defects

Gaining new insights into bacterial pneumonia

Myeloid cell can suppress the immune response to tumor cells

Researchers examine cooperative tumorigenic effects of targeted deletions of tumor suppressors

How Artificial Intelligence aids Gene Activation Discovery

Highly expressed DDX1 gene is associated with poor survival of neuroblastoma

Study reveals efficient expression system for production of coagulation factor XIIIa

Epigenomic data can help characterize genes that play key role in cancer progression

New spatial mapping method pinpoints new potential therapeutic targets for lupus

Scientists develop CRISPR-assisted method to detect RNA-binding proteins in living cells

Study identifies complex functional, physical interactions between p53 gene and the INSR pathway

A metabolic enzyme could be a potential drug target for B cell lymphomas

Developments in Engineered T Cells for Type 1 Diabetes

Breaking Down the DNA Behavior of Cancer Cells

New study on transposable elements could help advance understanding of genetic evolution

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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