Apoptosis News and Research

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Apoptosis is programmed cell death, the body's normal method of disposing of damaged, unwanted, or unneeded cells.

Targeting RNA splicing can trigger antiviral immune pathways in triple-negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

Study determines 3D structure of molecular machine involved in placement of key proteins

Within a single cell, more than a quarter of all proteins are found in the membrane, in which they carry out crucial functions.

7 Dec 2020

Gasdermin E triggers pyroptosis and involved in pathogen-induced coral death

Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against the infection of bacterial and viral pathogens. Pyroptosis is executed by gasdermin, a family of pore-forming proteins.

7 Dec 2020

Protein interactions could serve as therapeutic targets to treat viral infections

Researchers have investigated the role of the interplays within the proteins membranes of viral families involved in the control of programmed cell death.

30 Nov 2020

Researchers create “developmental atlas” to classify the neurons of fruit flies

Using machine learning and gene sequencing, scientists from New York University have designed a “developmental atlas” of gene expression in neurons to classify over 250,000 neurons in the brains of fruit flies.

5 Nov 2020

Genetic predispositions affect the efficacy of COVID-19 drugs

A paper recently uploaded to bioRxiv* aimed to utilize genome-wide CRISPR screening to identify genes involved in modulating the activity of COVID-19 drugs.

29 Oct 2020

Researchers assign immunological memory function to cytotoxic natural killer cells

A new study by researchers from the Medical University of Vienna could prove beneficial for the human immune system.

21 Oct 2020

A combinational approach to fight against cancer

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach.

14 Oct 2020

Researchers identify new mechanism that protects against Salmonella infection

Mice study has revealed a formerly unknown interaction between an immune cell protein and molecules extracted from dietary fiber.

30 Sep 2020

Researchers identify protein that makes cancer cells more aggressive

When Goping’s research team found that a protein was linked to poor outcomes in breast cancer patients, she wanted to find out the reason behind this.

10 Sep 2020

Novel molecular survival strategy of Shigella bacterium uncovered

Enteric pathogens, such as the bacterium Shigella, can cause severe intestinal disease with bloody diarrhea. In a new study, researchers from Tokyo Medical and Dental University (TMDU) discovered a novel molecular survival strategy by which Shigella is able to cause damage to the intestines despite two elaborate protective mechanisms used by host cells.

19 Aug 2020

Study shows DNA damage causes cells to reprogram themselves into stem cells

Researchers have discovered that when DNA in the moss Physcomitrella patens is damaged, it causes cells to reprogram on their own to change into stem cells.

19 Aug 2020

Scientists discover bacteria's secret weapon to evade immune responses

Monash Biomedicine Discovery Institute scientists have discovered a previously unknown method used by bacteria to evade immune responses.

18 Aug 2020

Enhancing Breast Cancer Therapy through Killing ‘Sleeper Cells’

AZoLifeSciences speaks to Dr. James Whittle and Professor Geoff Lindeman about their research in enhancing breast cancer therapy through killing sleeper cells.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 6 Aug 2020

Researchers identify mechanism that prevents death of neurons

When our neurons -- the principle cells of the brain -- die, so do we. Most neurons are created during embryonic development and have no "backup" after birth.

27 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Environmental pollutants pose risks to finless porpoises

A new study has revealed that environmental pollutants pose toxicological risks to finless porpoises (Neophocaena asiaeorientalis).

21 Jul 2020

Scientists gain insights into how parasitic bacterium gives rise to lesions

Bacteria of the genus Bartonella are parasites that can be transmitted to humans via insect bites and animal scratches, resulting in an infection known as "bartonellosis." Cat-scratch disease and trench fever are forms of bartonellosis caused by different Bartonella species infecting humans.

17 Jul 2020

Scientists study how cancer cells in the liver react to magnetic nanoparticles

Scientists from the Immanuel Kant Baltic Federal University and National University of Science and Technology "MISiS" have studied how magnet nanoparticles affect cancer cells in the human liver.

26 Jun 2020